Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology

References

• Glass CK, Saijo K, Winner B, Mechanisms underlying inflammation in neurodegeneration. Cell 2010;140:918–34.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Rao DM, Shamasundar NM. Studies on genomic DNA stability in aluminium maltolate treated aged New Zealand rabbit: relevance to the Alzheimer's animal model. J Clin Med Res 2009;1:212–8.
   PubMedGoogle Scholar
• Obulesu M, Rao DM. Animal models of Alzheimer's disease: an understanding of pathology and therapeutic avenues. Int J Neurosci 2010;120:531–7.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Rao DM. DNA damage and impairment of DNA repair in Alzheimer's disease. Int J Neurosci 2010; 120:397–403.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Venu R, Somashekhar R. Lipid peroxidation in Alzheimer's disease: emphasis on metal mediated neurotoxicity. Acta Neurol Scand 2011a;124:295–301.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Somashekhar R, Venu R. Genetics of Alzheimer's disease: Apo E and presenilins instigated neurodegeneration. Int J Neurosci 2011b;121:229–36.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Dowlathabad MR, Bramhachari PV. Carotenoids and Alzheimer's disease: an insight into therapeutic role of retinoids in animal models. Neurochem Int 2011c;59:535–41.
   PubMed Web of Science ®Google Scholar
• Obulesu M, Venu R, Somashekhar R. Tau mediated neurodegeneration: an insight into Alzheimer's disease pathology. Neurochem Res 2011d;36:1329–35.
   PubMed Web of Science ®Google Scholar
• Cowan CM, Chee F, Shepherd D, Disruption of neuronal function by soluble hyperphosphorylated tau in a Drosophila model of tauopathy. Biochem Soc Trans 2010;38:564–70.
   PubMed Web of Science ®Google Scholar
• Upadhaya AR, Lungrin I, Yamaguchi H, High-molecular weight Aβ-oligomers and protofibrils are the predominant Aβ-species in the native soluble protein fraction of the AD brain. J Cell Mol Med 2011;16:287–95.
   Web of Science ®Google Scholar
• Shudo K, Fukasawa H, Nakagomi M, Towards retinoid therapy for Alzheimer's disease. Curr Alzheimer Res 2009;6:302–11.
   PubMed Web of Science ®Google Scholar
• Igarashi M, Ma K, Gao F, Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex. J Alzheimers Dis 2011;24:507–17.
   PubMed Web of Science ®Google Scholar
• Fields J, Gardner-Mercer J, Borgmann K, CCAAT/ enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. J Neurochem 2011;118:93–104.
   PubMed Web of Science ®Google Scholar
• Calderon-Garciduenas L, Kavanaugh M, Block M, Neuroinflammation, Alzheimer's disease-associated pathology, and down-regulation of the prion-related protein in air pollution exposed children and young adults. J Alzheimers Dis 2011;28:93–107.
   Google Scholar
• MohanKumar SM, Campbell A, Block M, Particulate matter, oxidative stress and neurotoxicity. Neurotoxicology 2008;29:479–88.
   PubMed Web of Science ®Google Scholar
• Block ML, Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 2009;32:506–16.
   PubMed Web of Science ®Google Scholar
• Cunningham C, Campion S, Lunnon K, Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry 2009;65:304–12.
   PubMed Web of Science ®Google Scholar
• Allaman I, Be langer M, Magistretti PJ. Astrocyte–neuron metabolic relationships: for better and for worse. Trends Neurosci 2011;34:76–87.
   PubMed Web of Science ®Google Scholar
• Benoit ME, Tenner AJ. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and MicroRNA expression. J Neurosci 2011;31:3459–69.
   PubMed Web of Science ®Google Scholar
• Akiyama H. Inflammatory response in Alzheimer's disease. Tohoku. J Exp Med 1994;174:295–303.
   PubMed Web of Science ®Google Scholar
• Pizza V, Agresta A, D'Acunto CW, Neuroinflamm-aging and neurodegenerative diseases: an overview. CNS neurol disord drug targets 2011;10:621–34.
   PubMed Web of Science ®Google Scholar
• Gao XF, Wang W, Yu Q, Astroglial P2×7 receptor current density increased following long-term exposure to rotenone. Purinergic Signal 2011;7:65–72.
   PubMed Web of Science ®Google Scholar
• Heun R, Kolsch H, Ibrahim-Verbaas CA, Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis Project. Int J Mol Epidemiol Genet 2012;3:39–47.
   PubMedGoogle Scholar
• Anthony IC, Norrby KE, Dingwall T, Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain 2010;133:3685–98.
   PubMed Web of Science ®Google Scholar
• Tan J, Town T, Crawford F, Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci 2002; 5:1288–93.
   PubMed Web of Science ®Google Scholar
• McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 2007;28:639–47.
   PubMed Web of Science ®Google Scholar
• Metcalfe MJ, Figueiredo-Pereira ME. Relationship between tau pathology and neuroinflammation in Alzheimer's disease. Mt Sinai J Med 2010;77:50–8.
   PubMedGoogle Scholar
• Giunta B, Rezai-Zadeh K, Tan J. Impact of the CD40-CD40L dyad in Alzheimer's disease. CNS Neurol Disord Drug Targets 2010;9:149–55.
   PubMed Web of Science ®Google Scholar
• Morimoto K, Horio J, Satoh H, Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology. J Alzheimers Dis 2011;25:59–76.
   PubMed Web of Science ®Google Scholar
• Frankola KA, Greig NH, Luo W, Targeting TNF-Alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets 2011;10:391–403.
   PubMed Web of Science ®Google Scholar
• Hanyu H, Abe S, Arai H, Diagnostic accuracy of single photon emission CT in Alzheimer-type dementia. Nippon Ronen Igakkai Zasshi 1992;29:463–468.
   PubMedGoogle Scholar
• int'Veld BA, Ruitenberg A, Hofman A, Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345:1515–21.
   PubMed Web of Science ®Google Scholar
• Szekely CA, Town T, Zandi PP. NSAIDs for the chemoprevention of Alzheimer's disease. Subcell Biochem 2007;42:229–48.
   PubMedGoogle Scholar
• Schlatterer SD, Tremblay MA, Acker CM, Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain. J Alzheimers Dis 2011;25:119–33.
   PubMed Web of Science ®Google Scholar
• Vodovotz Y, Lucia MS, Flanders KC, Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med 1996;184:1425–33.
   PubMed Web of Science ®Google Scholar
• Lee SC, Zhao ML, Hirano A, Inducible nitric oxide synthase immunoreactivity in the Alzheimer disease hippocampus: association with Hirano bodies, neurofibrillary tangles, and senile plaques. J Neuropathol Exp Neurol 1999;58:1163–1169.
   PubMed Web of Science ®Google Scholar
• Heneka MT, Kummer MP, Weggen S, Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Curr Alzheimer Res 2011;8:115–31.
   PubMed Web of Science ®Google Scholar
• Li B, Zhong L, Yang X, WNT5A signaling contributes to Ab-induced neuroinflammation and neurotoxicity. PLoS ONE 2011;6:e22920.
   Web of Science ®Google Scholar
• He FQ, Qiu BY, Zhang XH, Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1–42). Brain Res 2011;1384:89–96.
   PubMed Web of Science ®Google Scholar
• Akiyama H, Barger S, Barnum S, Inflammation and Alzheimer's disease. Neurobiol Aging 2000;21:383–421.
   PubMed Web of Science ®Google Scholar
• Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol. 2007;184:69–91.
   PubMed Web of Science ®Google Scholar
• Shukla MS, Sharma SK. Sinomenine inhibits microglial activation by Aβ and confers neuroprotection. J Neuroinflammation 2011;8:117.
   PubMed Web of Science ®Google Scholar
• Brown GC. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans. 2007;35:1119–1121.
   PubMed Web of Science ®Google Scholar
• Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005;76:77–98.
   PubMed Web of Science ®Google Scholar
• Sastre M, Walter J, Gentleman SM. Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 2008;5:25.
   PubMed Web of Science ®Google Scholar
• Sly LM, Krzesicki RF, Brashler JR, Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res Bull 2001;56:581–8.
   PubMed Web of Science ®Google Scholar
• Rubio-Perez JM, Morillas-Ruiz JM. A review: inflammatory process in Alzheimer's disease, role of cytokines. ScientificWorldJournal 2012;2012:756357.
   PubMed Web of Science ®Google Scholar
• Pun PB, Lu J, Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res 2009;43:348–64.
   PubMed Web of Science ®Google Scholar
• Biron KE, Dickstein DL, Gopaul R, Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS ONE 2011;6:e23789.
   PubMed Web of Science ®Google Scholar
• Eikelenboom P, Bate C, Van Gool WA, Neuroinflammation in Alzheimer's disease and prion disease. Glia 2002;40:232–9.
   PubMed Web of Science ®Google Scholar
• McGeer EG, McGeer PL. Inflammatory processes in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:741–9.
   PubMed Web of Science ®Google Scholar
• Gramowski A, Flossdorf J, Bhattacharya K, Nanoparticles induce changes of the electrical activity of neuronal networks on microelectrode array neurochips. Environ Health Perspect 2010;118:1363–9.
   PubMed Web of Science ®Google Scholar
• Wu J, Wang C, Sun J, Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. ACS Nano 2011;5:4476–89.
   PubMed Web of Science ®Google Scholar
• Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) 2012;60:251–66.
   PubMed Web of Science ®Google Scholar
• Jimenez S, Baglietto-Vargas D, Caballero C, Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci 2008;28:11650–61.
   PubMed Web of Science ®Google Scholar
• Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 2007;8:663–72.
   PubMed Web of Science ®Google Scholar
• Cai Z, Ratka A. Opioid system and Alzheimer's disease. Neuromolecular Med 2012;14:91–111.
   PubMed Web of Science ®Google Scholar
• Clawson CC. Platelets in bacterial infections. In: Joseph M, ed. Immunopharmacology of platelets. London/New York: Academic Press; 1995:83–124.
   Google Scholar
• Joseph M. The generation of free radicals by blood platelets 1995. In: Joseph M, ed. Chapter 11, immunopharmacology of platelets. London/New York: Academic Press; 1995: 209–23.
   Google Scholar
• Herd CM, Page CP. Do platelets have a role as inflammatory cells? In: Joseph M, ed. Chapter 2, immunopharmacology of platelets. London/New York: Academic Press; 1995:1–12.
   Google Scholar
• McGregor JL. The role of human platelet membrane receptors in inflammation 1995. In: Joseph M, ed. Chapter 4 (see also Ch. 2), immunopharmacology of platelets. London/New York: Academic Press; 1995:66–82.
   Google Scholar
• Horstman LL, Jy W, Ahn YS, Role of platelets in neuroinflammation: a wide-angle perspective. J Neuroinflammation 2010;7:10.
   PubMed Web of Science ®Google Scholar
• Soga F, Katoh N, Inoue T, Serotonin activates human monocytes and prevents apoptosis. J Invest Dermatol 2007;127:1947–55.
   PubMed Web of Science ®Google Scholar
• Sevush S, Jy W, Horstman LL, Platelet activation in Alzheimer's disease. Arch Neurol 1998;55:530–6.
   PubMedGoogle Scholar
• Ciabattoni G, Porreca E, DiFebbo C, Determinants of platelet activation in Alzheimer's disease. Neurobiol Aging 2007;28:336–42.
   PubMed Web of Science ®Google Scholar
• Mrak RE, Landreth GE. PPARgamma, neuroinflammation and disease. J Neuroinflammation 2004;1:5.
   PubMed Web of Science ®Google Scholar
• Heneka MT, Landreth GE. PPARs in the brain. Biochim Biophys Acta 2007;1771:1031–45.
   PubMed Web of Science ®Google Scholar
• Kummer MP, Heneka MT. PPARs in Alzheimer's disease. PPAR Res 2008;2008:403896.
   PubMed Web of Science ®Google Scholar
• Casoli T, Di Stefano G, Balietti M, et al.. Peripheral inflammatory biomarkers of Alzheimer's disease: the role of platelets. Biogerontology. 2010;11:627–33.
   PubMed Web of Science ®Google Scholar
• Chaturvedi RK, Beal MF. PPAR: a therapeutic target in Parkinson's disease. J Neurochem 2008;106:506–18.
   PubMed Web of Science ®Google Scholar
• Liberto CM, Albrecht PJ, Herx LM, Pro-regenerative properties of cytokine activated astrocytes. J Neurochem 2004;89:1092–100.
   PubMed Web of Science ®Google Scholar
• Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007;28:138–45.
   PubMed Web of Science ®Google Scholar
• Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010;119:7–35.
   PubMed Web of Science ®Google Scholar
• Wang C, Yang XM, Zhuo YY, The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats. Int J Neuropsychopharmacol 2011;9:1–18.
   Google Scholar
• John GR, Lee SC, Brosnan CF. Cytokines: powerful regulators of glial cell activation. Neuroscientist 2003;9:10–22.
   PubMed Web of Science ®Google Scholar
• Teeling JL, Perry VH. Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience 2009;158:1062–73.
   PubMed Web of Science ®Google Scholar
• Nagele RG, D'Andrea MR, Lee H, Astrocytes accumulate Abeta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 2003;971:197–209.
   PubMed Web of Science ®Google Scholar
• Olabarria M, Noristani HN, Verkhratsky A, Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 2010;58:831–8.
   PubMed Web of Science ®Google Scholar
• Simpson JE, Ince PG, Lace G, Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiol Aging 2010;31:578–90.
   PubMed Web of Science ®Google Scholar
• Wyss-Coray T, Loike JD, Brionne TC, Adult mouse astrocytes degrade amyloid beta in vitro and in situ. Nat Med 2003;9:453–7.
   PubMed Web of Science ®Google Scholar
• Koistinaho M, Lin S, Wu X, Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 2004;10:719–26.
   PubMed Web of Science ®Google Scholar
• Allaman I, Gavillet M, Belanger M, Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. J Neurosci 2010;30:3326–38.
   PubMed Web of Science ®Google Scholar
• Nagele RG, Wegiel J, Venkataraman V, Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging 2004;25:663–74.
   PubMed Web of Science ®Google Scholar
• Kuchibhotla KV, Lattarulo CR, Hyman BT, Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 2009;323:1211–5.
   Google Scholar
• Nagy JI, Li W, Hertzberg EL, Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer's disease. Brain Res 1996;717:173–8.
   PubMed Web of Science ®Google Scholar
• Mei X, Ezan P, Giaume C, Astroglial connexin immunoreactivity is specifically altered at beta-amyloid plaques in beta-amyloid precursor protein/presenilin1 mice. Neuroscience 2010;171:92–105.
   PubMed Web of Science ®Google Scholar
• Abramov AY, Canevari L, Duchen MR. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci 2003;23:5088–95.
   PubMed Web of Science ®Google Scholar
• Abramov AY, Canevari L, Duchen MR. Beta-amyloid peptides inducemitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 2004;24:565–75.
   PubMed Web of Science ®Google Scholar
• Paradisi S, Sacchetti B, Balduzzi M, Astrocyte modulation of in vitro beta-amyloid neurotoxicity. Glia 2004;46:252–60.
   PubMed Web of Science ®Google Scholar
• Obradovic SD, Antovic JP, Antonijevic NM, Elevations in soluble CD40 ligand in patients with high platelet aggregability undergoing percutaneous coronary intervention. Blood Coagul Fibrinolysis 2009;20:283–9.
   PubMed Web of Science ®Google Scholar
• Lessiani G, Dragani A, Falco A, Soluble CD40 ligand and endothelial dysfunction in aspirin-treated polycythaemia vera patients. Br J Haematol 2009;145:538–40.
   PubMed Web of Science ®Google Scholar
• Ait-Ghezala G, Mathura VS, Laporte V, Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease. Brain Res Mol Brain Res 2005;140:73–85.
   PubMedGoogle Scholar
• Tan J, Town T, Paris D, Microglial activation resulting from CD40–CD40L interaction after beta-amyloid stimulation. Science 1999;286:2352–5.
   PubMed Web of Science ®Google Scholar
• Henn V, Slupsky JR, Grafe M, CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998;391:591–4.
   PubMed Web of Science ®Google Scholar
• van Kooten C, Banchereau J. CD-40-CD-40 ligand. J Leukoc Biol 2000;67:2–17.
   PubMed Web of Science ®Google Scholar
• Schonbeck U, Libby P. The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 2001;58:4–43.
   PubMed Web of Science ®Google Scholar
• Cipollone F, Chiarelli F, Davi G, Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control. Diabetologia 2005;48:1216–24.
   PubMed Web of Science ®Google Scholar
• Chen K, Huang J, Gong W, CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system. Cell Mol Immunol 2006;3:163–9.
   PubMed Web of Science ®Google Scholar
• Chakrabarti S, Rizvi M, Pathak D, Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. Immunol Lett 2009;122:170–84.
   PubMed Web of Science ®Google Scholar
• Tamagno E, Guglielmotto M, Monteleone D, et al.. Transcriptional and post-transcriptional regulation of β-secretase. UBMB Life 2012;64:943–50.
   PubMed Web of Science ®Google Scholar
• Ricciarelli R, D'Abramo C, Zingg JM, CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease. Free Radic Biol Med 2004;36:1018–24.
   PubMed Web of Science ®Google Scholar
• Fernandez-Botran R, Ahmed Z, Crespo FA, Cytokine expression and microglial activation in progressive supranuclear palsy. Parkinsonism Relat Disord 2011;17: 683–8.
   PubMed Web of Science ®Google Scholar
• Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81:741–66.
   PubMed Web of Science ®Google Scholar
• Kitazawa M, Yamasaki TR, LaFerla FM. Microglia as a potential bridge between the amyloid betapeptide and tau. Ann N Y Acad Sci 2004;1035:85–103.
   PubMed Web of Science ®Google Scholar
• Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 2006;12:1005–15.
   PubMed Web of Science ®Google Scholar
• Landreth GE, Reed-Geaghan EG. Toll-like receptors in Alzheimer's disease. Curr Top Microbiol Immunol 2009;336:137–53.
   PubMed Web of Science ®Google Scholar
• Reed-Geaghan EG, Savage JC, Hise AG, CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci 2009;29:11982–92.
   PubMed Web of Science ®Google Scholar
• Walter S, Letiembre M, Liu Y, Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol Biochem 2007;20:947–56.
   PubMed Web of Science ®Google Scholar
• Stewart CR, Stuart LM, Wilkinson K, CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 2009;11:155–61.
   Google Scholar
• Mocali A, Cedrola S, Della Malva N, Increased plasma levels of soluble CD40, together with the decrease of TGF beta 1, as possible differential markers of Alzheimer disease. Exp Gerontol 2004;39:1555–61.
   PubMed Web of Science ®Google Scholar
• Song Y, Chen X, Wang LY, Rho kinase inhibitor Fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats. CNS Neurosci Ther 2013;19:603–10.
   PubMed Web of Science ®Google Scholar
• Montgomery SL, Narrow WC, Mastrangelo MA, Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer's disease mice leads to significant modulation of amyloid- and Tau-related pathologies. Am J Pathol 2013;182:2285–97.
   PubMed Web of Science ®Google Scholar
• Kurnellas MP, Adams CM, Sobel RA, Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Sci Transl Med 2013;5:179ra42.
   PubMed Web of Science ®Google Scholar
• McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J Alzheimers Dis 2006;9:271–6.
   PubMed Web of Science ®Google Scholar
• Meda L, Cassatella MA, Szendrei GI, Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 1995;374:647–50.
   PubMed Web of Science ®Google Scholar
• Todd Roach J, Volmar CH, Dwivedi S, Behavioral effects of CD40–CD40L pathway disruption in aged PSAPP mice. Brain Res 2004;1015:161–8.
   PubMed Web of Science ®Google Scholar
• Laporte V, Ait-Ghezala G, Volmar CH, CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models. J Neuroinflammation 2006;3:3.
   PubMed Web of Science ®Google Scholar
• Townsend KP, Town T, Mori T, CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. Eur J Immunol 2005;35:901–10.
   PubMed Web of Science ®Google Scholar
• Ait-ghezala G, Abdullah L, Volmar CH, Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1–40 levels in plasma in Alzheimer's disease. Cytokine 2008;44: 283–7.
   PubMed Web of Science ®Google Scholar
• Desideri G, Cipollone F, Necozione S, Enhanced soluble CD40 ligand and Alzheimer's disease: evidence of a possible pathogenetic role. Neurobiol Aging 2008;29:348–56.
   PubMed Web of Science ®Google Scholar
• Nikolic WV, Hou H, Town T, Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev 2008;17:423–39.
   PubMed Web of Science ®Google Scholar
• Buchhave P, Janciauskiene S, Zetterberg H, Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease. Neurosci Lett 2009;450:56–9.
   PubMed Web of Science ®Google Scholar
• Lacoste B, Tong XK, Lahjouji K, Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice. J Neuroinflammation 2013;10:57.
   PubMed Web of Science ®Google Scholar
• Devore EE, Grodstein F, van Rooij FJ, Dietary antioxidants and long-term risk of dementia. Arch Neurol 2010;67:819–25.
   PubMed Web of Science ®Google Scholar
• Pac-Soo C, Lloyd DG, Vizcaychipi MP, Statins: the role in the treatment and prevention of Alzheimer's neurodegeneration. J Alzheimers Dis 2011;27:1–10.
   PubMed Web of Science ®Google Scholar
• Yoshiyama Y, Higuchi M, Zhang B, Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007;53:337–51.
   PubMed Web of Science ®Google Scholar
• Candelario-Jalil E, Gonzalez-Falcon A, Garcia-Cabrera M, Post-ischaemic treatment with the cyclooxygenase- 2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. J Neurochem 2007a;100:1108–20.
   PubMed Web of Science ®Google Scholar
• Candelario-Jalil E, Taheri S, Yang Y, Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther 2007b;323:488–98.
   PubMed Web of Science ®Google Scholar
• Britschgi M, Wyss-Coray T. Immune cells may fend off Alzheimer disease. Nat Med 2007;13:408–9.
   PubMed Web of Science ®Google Scholar
• El Khoury J, Toft M, Hickman SE, Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 2007;13: 432–8.
   PubMed Web of Science ®Google Scholar
• Ferretti MT, Cuello AC. Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? Curr Alzheimer Res 2011;8:164–74.
   PubMed Web of Science ®Google Scholar
• Grathwohl SA, Kalin RE, Bolmont T, Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 2009;12:1361–3.
   PubMed Web of Science ®Google Scholar