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META-ANALYSIS

Association between endothelial nitric oxide synthase gene polymorphism (T-786C) and ischemic stroke susceptibility: a meta-analysis

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Pages 642-651 | Received 21 Aug 2013, Accepted 08 Dec 2013, Published online: 16 Jan 2014

References

  • Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet, 2008;371(9624):1612–23.
  • Liu L, Wang D, Wong KS, Wang Y. Stroke and stroke care in China: huge burden, significant workload, and a national priority. Stroke, 2011;42(12):3651–4.
  • Brass LM, Isaacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke, 1992;23(2):221–3.
  • Elbaz A, Amarenco, P. Genetic susceptibility and ischaemic stroke. Curr Opin Neurol, 1999;12(1):47–55.
  • Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab, 1994;14(2):175–92.
  • Faraci, FM, Brian JE Jr., Nitric oxide and the cerebral circulation. Stroke, 1994;25(3):692–703.
  • Moncada S, Higgs EA. Nitric oxide and the vascular endothelium. Handb Exp Pharmacol, 2006(176 Pt 1):213–54.
  • Fatini C, Sofi F, Sticchi E, Gensini F, Gori AM, Influence of endothelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperhomocysteinemia on the predisposition to acute coronary syndromes. Am Heart J, 2004;147(3):516–21.
  • Elbaz A, Poirier O, Moulin T, Chédru F, Cambien F, Amarenco P. Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. The GENIC Investigators. Stroke, 2000;31(7):1634–9.
  • Ozüm U, Bolat N, Gül E, Ozdemir O. Endothelial nitric oxide synthase gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage. Acta Neurochir (Wien), 2008;150(1):57–61; discussion 62.
  • Chen Y, Huang H, Zhou J, Doumatey A, Lashley K, Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans. Mol Vis, 2007;13:2142–7.
  • Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem, 1992;267(21):14519–22.
  • Shi XM, Tsui LC, Schappert KT. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem, 1993;268(23):17478–88.
  • Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun, 1994;198(3):1027–33.
  • Hou L, Osei-Hyiaman D, Yu H, Ren Z, Zhang Z, Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients. Neurology, 2001;56(4): 490–6.
  • Markus, Ruigrok Y, Ali N, Powell JF. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Stroke, 1998;29(9):1908–11.
  • Macleod MJ, DahiyAat MT, Cumming A, Meiklejohn D, Shaw D, ST Clair D. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. Neurology, 1999;53(2): 418–20.
  • Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, T-786–>C mutation in the 5’-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation, 1999;99(22):2864–70.
  • Hassan A, Gormley K, O'Sullivan M, Knight J, Sham P, Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke, 2004;35(3):654–9.
  • Howard TD, Giles WH, Xu J, Wozniak MA, Malarcher AM, Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women. Stroke, 2005;36(9):1848–51.
  • Cheng J, Liu J, Li X, Yu L, Peng J, Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese population. Clin Chim Acta, 2008;392(1–2):46–51.
  • Saidi S, Mallat SG, Almawi WY, Mahjoub T. Endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene polymorphisms and the risk of ischemic stroke. Acta Neurol Scand, 2010;121(2):114–9.
  • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ, 2003;327(7414): 557–60.
  • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959;22(4):719–48.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986;7(3):177–88.
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997;315(7109):629–34.
  • Moe KT, Woon FP, De Silva DA, Wong P, Koh TH, Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population. Eur J Neurol, 2008;15(12): 1309–14.
  • Majumdar V, Nagaraja D, Karthik N, Christopher R. Association of endothelial nitric oxide synthase gene polymorphisms with early-onset ischemic stroke in South Indians. J Atheroscler Thromb, 2010;17(1):45–53.
  • Yemişçi M, Sinici I, Ozkara HA, Hayran M, Ay H, Celtikçi B, Protective role of 27bp repeat polymorphism in intron 4 of eNOS gene in lacunar infarction. Free Radic Res, 2009;43(3):272–9.
  • Kim OJ, Kim UK, Oh SH, Cho YW, Oh KI, Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus. Mol Med Rep, 2010;3(3): 509–13.
  • LI XX, Y.Y., Zhang CJ, Liu JP. The relationship between polymorphisms in endothelial nitric oxide synthase gene and cerebral ischemic stroke in Mudanjiang. J Mudanjiang Med Univ, 2011;32:31–5.
  • Song J, Kim OJ, Kim HS, Bae SJ, Hong SP, Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction. Int J Mol Med, 2010;25(5):819–23.
  • Yan JT, Zhang L, Xu YJ, Wang XJ, Wang CY, Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population. Acta Pharmacol Sin, 2011;32(11):1357–63.
  • Meng XJ, Xu LX, Lin Q, Tian Y, Ren YF, Association of endothelial nitric oxide synthase gene polymorphisms with ischemic cerebrovascular disease. Chinese Journal of Gerontology, 2012;32:1567–1569.
  • Mohr JP. Some clinical aspects of acute stroke. Excellence in Clinical Stroke Award Lecture. Stroke, 1997;28(9):1835–9.
  • Akar N, Akar E, Deda G, Sipahi T. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. Neurology, 2000;55(3):460–1.
  • Ellul J, Markoula S, Marousi S, Galidi A, Kyritsis AP, Association of endothelial nitric oxide synthase polymorphism G894T with functional outcome in acute stroke patients. Neurol Res, 2011;33(8):835–40.
  • Niu PP, Yang G, Zheng BK, Guo ZN, Jin H, Yang Y. Relationship between endothelial nitric oxide synthase gene polymorphisms and ischemic stroke: a meta-analysis. Acta Neurol Scand, 2013;128(3):202–12.
  • Wang M, Jiang X, Wu W, Zhang D. Endothelial NO synthase gene polymorphisms and risk of ischemic stroke in Asian population: a meta-analysis. PLoS One, 2013;8(3):e60472.

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