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Original Article

Hypertension alters phosphorylation of VASP in brain endothelial cells

, , , , , , , , , , & show all
Pages 288-297 | Received 07 Oct 2013, Accepted 30 May 2014, Published online: 03 Jul 2014

References

  • Dahlof B. Prevention of stroke in patients with hypertension. Am J Cardiol 2007;100(3A):17–24.
  • Jiang B, Yao G, Yao C, et al. Vascular cognitive impairment with no dementia: neuropsychology, brain imaging, and event-related potentials. Neurophysiol 2013;45:323–8.
  • Faraci FM, Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 1998;78:53–97.
  • Schlegel N, Burger S, Golenhofen N, et al. The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization. Am J Physiol Cell Physiol 2008;294:178–88.
  • Miller VM, Vanhoutte PM. Enhanced release of endothelium-derived factor(s) by chronic increases in blood flow. Am J Physiol 1988;255:446–51.
  • Rubanyi GM, Vanhoutte PM. Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am J Physiol 1986;250:815–21.
  • Halbrugge M, Walter U. Purification of a vasodilator-regulated phosphoprotein from human platelets. Eur J Biochem 1989;185:41–50.
  • Draijer R, Vaandrager AB, Nolte C, et al. Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin. Circ Res 1995;77:897–905.
  • Reinhard M, Halbrügge M, Scheer U, et al. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J 1992;11:2063–70.
  • Vasioukhin V, Bauer C, Yin M, Fuchs E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 2000;100:209–19.
  • Girouard H, Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol 2006;100:328–35.
  • Sobey CG, Faraci FM. Novel mechanisms contributing to cerebral vascular dysfunction during chronic hypertension. Curr Hypertens Rep 2001;3:517–23.
  • Sporbert A, Mertsch K, Smolenski A, et al. Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes. Brain Res Mol Brain Res 1999;67:258–66.
  • Schäfer A, Widder J, Eigenthaler M, et al. Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats. Biochem Pharmacol 2004;67:2273–9.
  • Gündüz F, Koçer G, Ulker S, et al. Exercise training enhances flow-mediated dilation in spontaneously hypertensive rats. Physiol Res 2011;60:589–97.
  • Kayisli UA, Selam B, Demir R, Arici A. Expression of vasodilator-stimulated phosphoprotein in human placenta: possible implications in trophoblast invasion. Mol Hum Reprod 2002;8:88–94.
  • Lockwood CJ, Oner C, Uz YH, et al. Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells. Biol Reprod 2008;78:1064–72.
  • Guzeloglu Kayisli O, Kayisli UA, Luleci G, Arici A. In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent. Biol Reprod 2004;71:714–21.
  • Blume C, Benz PM, Walter U, et al. AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem 2007;282:4601–12.
  • Benz PM, Blume C, Moebius J, et al. Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. J Cell Biol 2008;180:205–19.
  • Furman C, Sieminski AL, Kwiatkowski AV, et al. Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol 2007;179:761–75.
  • Schlegel N, Waschke J. Impaired integrin-mediated adhesion contributes to reduced barrier properties in VASP-deficient microvascular endothelium. J Cell Physiol 2009;220:357–66.
  • Kwiatkowski AV, Rubinson DA, Dent EW, et al. Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron 2007;56:441–55.
  • Comerford KM, Lawrence DW, Synnestvedt K, et al. Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J 2002;16:583–5.
  • Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998;91:3527–61.
  • Rochette L, Lorin J, Zeller M, et al. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets? Pharmacol Ther 2013. pii: S0163–7258(13)00150–2. doi: 10.1016/j.pharmthera.2013.07.004. [Epub ahead of print].
  • Rosenberger P, Khoury J, Kong T, et al. Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia. FASEB J 2007;21:2613–21.
  • Aszódi A, Pfeifer A, Ahmad M, et al. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 1999;18:37–48.
  • Chen L, Daum G, Chitaley K, et al. Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2004;24:1403–8.
  • Melichar VO, Behr-Roussel D, Zabel U, et al. Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci USA 2004;101:16671–6.
  • Pula G, Krause M. Role of Ena/VASP proteins in homeostasis and disease. Handb Exp Pharmacol 2008;186:39–65.
  • Schlegel N, Waschke J. VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells. Am J Physiol Cell Physiol 2009;296:453–62.
  • Rinder MR, Spina RJ, Ehsani AA. Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol 2000;88:761–6.
  • Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000;35:706–13.
  • Hambrecht R, Wolf A, Gielen S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000;342:454–60.
  • Woodman CR, Muller JM, Laughlin MH, Price EM. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol 1997; 273:2575–79.
  • Green DJ, Maiorana A, O’Driscoll G, Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol 2004;561:1–25.
  • Schäfer A, Flierl U, Kobsar A, et al. Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats. Arterioscler Thromb Vasc Biol 2006;26:2813–8.

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