Soluble or soluble/membrane TNF-± inhibitors protect the brain from focal ischemic injury in rats

References

• Roger VL, Go AS, Lloyd-Jones D, et al. Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation 2011;123:e18–e209.
   PubMed Web of Science ®Google Scholar
• Intiso D, Zarrelli MM, Lagioia G, et al. Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 2004;24:390–6.
   PubMed Web of Science ®Google Scholar
• Zaremba J, Losy J. Early TNF-alpha levels correlate with ischaemic stroke severity. Acta Neurol Scand 2001;104:288–95.
   PubMed Web of Science ®Google Scholar
• Nawashiro H, Tasaki K, Ruetzler CA, Hallenbeck JM. TNF-a pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 1997;17:483–90.
   PubMed Web of Science ®Google Scholar
• Barone FC, Arvin B, White RF, et al. Tumor necrosis factor-α. A mediator of focal ischemic brain injury. Stroke 1997;28:1233–44.
   PubMed Web of Science ®Google Scholar
• Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med 2011;17:796–808.
   PubMed Web of Science ®Google Scholar
• Broussalis E, Trinka E, Killer M, et al. Current therapies in ischemic stroke. Part B. Future candidates in stroke therapy and experimental studies. Drug Discovery Today 2012;17: 671–84.
   PubMed Web of Science ®Google Scholar
• Majid A. Neuroprotection in stroke: Past, present, and future. ISRN Neurol 2014;2014:515716.
   PubMedGoogle Scholar
• Tuttolomondo A, Di Sciacca R, Di Raimondo D, et al. Inflammation as a therapeutic target in acute ischemic stroke treatment. Curr Top Med Chem 2009;9:1240–60.
   PubMed Web of Science ®Google Scholar
• Scallon B, Cai A, Solowski N, et al. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther 2002;301:418–26.
   PubMed Web of Science ®Google Scholar
• Arango-Dávila CA, Pimienta H, Escobar M. Evaluación de un Modelo de Isquemia Cerebral experimental en ratas. Salud UIS 2002;34:195–201.
   Google Scholar
• Swanson RA, Morton MT, Tsao-Wu G, et al. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990;10:290–3.
   PubMed Web of Science ®Google Scholar
• Maddahi A, Kruse LS, Chen QW, Edvinsson L. The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat. J Neuroinflammation 2011;8:107.
   PubMed Web of Science ®Google Scholar
• Sairanen T, Carpen O, Karjalainen-Lindsberg ML, et al. Evolution of cerebral tumor necrosis factor- production during human ischemic stroke. Stroke 2001;32:1750–8.
   PubMed Web of Science ®Google Scholar
• Hosomi N, Ban CR, Naya T, et al. Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. J Cereb Blood Flow Metab 2005;25:959–67.
   PubMed Web of Science ®Google Scholar
• Sumbria RK, Boado RJ, Pardridge WM. Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein. J Cereb Blood Flow Metab 2012;32: 1933–8.
   PubMed Web of Science ®Google Scholar
• Gary DS, Bruce-Keller AJ, Kindy MS, Mattson MP. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J Cereb Blood Flow Metab 1998;18:1283–7.
   PubMed Web of Science ®Google Scholar
• Akassoglou K, Douni E, Bauer J, et al. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci 2003;100:709–14.
   PubMed Web of Science ®Google Scholar
• Fontaine V, Mohand-Said S, Hanoteau N, et al. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 2002;22:RC216.
   PubMed Web of Science ®Google Scholar
• Zaremba J, Losy J. Early TNF-alpha levels correlate with ischaemic stroke severity. Acta Neurol Scand 2001;104:288–95.
   PubMed Web of Science ®Google Scholar
• Boado R J, Hui EKW, Lu JZ, et al. Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein. J Biotechnol 2010;146:84–91.
   PubMed Web of Science ®Google Scholar
• Emsley H, Smith CJ, Gavin CM, et al. Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol 2007;28;7–5.
   Google Scholar
• Rallidis LS, Vikelis M, Panagiotakos DB, et al. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis 2006;189:193–7.
   PubMed Web of Science ®Google Scholar
• Domac FM, Somay G, Misirli H, Erenoglu NY. Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke. Neurosciences 2007;12:25–30.
   Web of Science ®Google Scholar