Association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke in the Chinese population: a meta-analysis

References

• Donnan GA, Fisher M, Macleod M, et al. Stroke. Lancet 2008;371:1612–23.
   PubMed Web of Science ®Google Scholar
• Ziganshina LE, Abakumova T, Kuchaeva A. Cerebrolysin for acute ischemic stroke. Cochrane Database Syst Rev 2010;CD007026.
   Google Scholar
• Liu L, Wang D, Wong KS, et al. Stroke and stroke care in China: huge burden, significant workload, and a national priority. Stroke 2011;42:3651–4.
   PubMed Web of Science ®Google Scholar
• Pezzini A, Grassi M, DelZotto E, et al. Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults. Stroke 2005;36:533–9.
   PubMed Web of Science ®Google Scholar
• Dhamija RK, Gaba P, Arora S, et al. Homocysteine and lipoprotein (a) correlation in ischemic stroke patients. J Neurol Sci 2009;281:64–8.
   PubMed Web of Science ®Google Scholar
• Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–3.
   PubMed Web of Science ®Google Scholar
• Signorello MG, Segantin A, Passalacqua M, et al. Homocysteine decreases platelet NO level via protein kinase C activation. Nitric Oxide 2009;20:104–13.
   PubMed Web of Science ®Google Scholar
• Brattström L, Wilcken DE, Ohrvik J, et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998;98:2520–6.
   PubMed Web of Science ®Google Scholar
• Goyette P, Pai A, Milos R, et al. Gene structure of humn and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 1998;9:652–6.
   PubMed Web of Science ®Google Scholar
• Kang SS, Wong PW, Bock HG, et al. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. Am J Hum Genet 1991;48:546–51.
   PubMed Web of Science ®Google Scholar
• Mejia Mohamed EH, Tan KS, Ali JM, et al. TT Genotype of the Methylenetetrahydrofolate Reductase C677T Polymorphism is an Important Determinant for Homocysteine Levels in Multi-Ethnic Malaysian Ischemic Stroke Patients. Ann Acad Med Singapore 2011;40:186–91.
   PubMed Web of Science ®Google Scholar
• Teng L, Zhao YB, Wang XC, et al. Relation between MTHFR gene polymorphism and arteriosclerotic cerebral infarction. HEREDITAS 1999;21:13–16.
   Google Scholar
• Zhang GS, Dai CW. Gene polymorphisms of homocysteine metabolism-related enzymes in chinese patients with occlusive coronary artery or cerebral vascular diseases. Thromb Res 2001;104:187–195.
   PubMed Web of Science ®Google Scholar
• Tu CQ, Huang MQ, Wu JZ, et al. The relation of methylenetetrahydrofolate reduetase gene mutation and cystathionine β-synthase gene mutation existin cerebral infarction. Chin J Thromb Hem 2002;8:149–51.
   Google Scholar
• Zhang Y, Xie RP, Wang MH, et al. Correlation of methylenetetrahydrofolate reductase gene polymorphism and cerebral infarction. Chin J Neurol 2003;36:73–74.
   Google Scholar
• Wu JM, Wang TG, Li YQ, et al. Genetic Mutations Enzymes in of Homocysteine Metabolism Related Patients with Ischemic Stroke. HEREDITAS 2004;26:298–302.
   PubMedGoogle Scholar
• Fang L, Wu YQ, Wang TW. Correlation of polymorphism of gene methylenetetrahydrofolate reductase and cystathionine beta-synthase with heredity of cerebral infarction and cerebral hemorrhage in northern Chinese Han people. Chin J Clin Rehabilitation 2004;8:4654–6.
   Google Scholar
• Li YJ, Huo Y, Gao XG, et al. A statistical study on the relationship between gene polymorphisms of β-fibrinogen 148C/T, N5, N10-methylene2tetra2hydrofolic acid reductase 677C/T and cerebral infarction. Chin J Neuroimmunol Neurol 2005;12:363–72.
   Google Scholar
• Xu E, Deng BM, Chen SQ, et al. The relationship between gene polymorphisms of MTRR A66G,MS D919G,MTHFR C677T and cerebral infarction. Chin J Neuromed 2005;4:902–7.
   Google Scholar
• Fu Y, Liu JR, Ni PH, et al. The relationship of plasma homocysteine levels and polymorphism in homocysteine metabolism related enzymes with brain stroke. Chin J Geriatr 2005;24: 413–7.
   Google Scholar
• Sun WP, Zhao JX, Wan Q, et al. Association of hyperhomocysteinemia reductase gene polymorphisms withChinese population. Chin J Clin Rehabil 2005;9:171–3.
   Google Scholar
• Xiao YQ, Jiang LL, Lu Q, et al. The relationship between the gene polymorphism of methylenetetrahydrofolate reductase and plasma homocysteine level with cerebrovascular disease. Lab Med 2006;21:201–4.
   Google Scholar
• Wang LJ, Niu XY, Ju XH, et al. Association of polymorphism of MTHFR gene and plasma homocysteine with stroke in Chinese youth and middle-aged adults. J Apoplexy Nerv Dis 2006;23:478–81.
   Google Scholar
• Li CM, Zhang C, Lu XL, et al. Relationship between methylenetrahydrofolate reductase gene and ischemic stroke. Chin Crit Care Med 2006;18:264–7.
   Google Scholar
• Nan GX, Cui MJ, Liu SY. Relationship between independent risk factor of ischemic Cerebrovascular disease in youth and genic mutation of methylenetetrahydrofolate reductase. Chin J Clin Rehabil 2006;10:184–6.
   Google Scholar
• Shao Y, Zhang CG, Hu XQ. Relationship of plasma homocysteine, polymorphism in its enzymes genes and cerebral infarction in the elderly. J Clin Neurol 2006;19:22–24.
   Google Scholar
• Gao XG, Huo Y, Teng ZP. Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke. Neurosci Lett 2006;398:172–77.
   PubMed Web of Science ®Google Scholar
• Zhou J, Li XX. The relationship between the C677T porlymorphism in the methylenetetrahydrofolate reductase gene and cerebral infarction. J Chin Stroke 2006;271–273.
   Google Scholar
• Li HN, Yang S, Hou XL, et al. A study on the relationship between MTHFR gene C677T polymorphism, plasma Hcy level and ischemic stroke in mid-adults and young adults of Ningxia. Ningxia Med J 2007;29:685–7.
   Google Scholar
• Shi CN, Kang XX, Wang YJ, et al. The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke. Clinica Chimica Acta 2008;396:7–9.
   PubMed Web of Science ®Google Scholar
• Yuan LH, Huang WX. A study of the association of MTHFR gene polymorphism with cerebral infarction. J Baotou Med College 2013;29:11–13.
   Google Scholar
• Cronin S, Furie KL, Kelly PJ. Dose-related association of MTHFR 677 T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005;36:1581–7.
   PubMed Web of Science ®Google Scholar
• Xin XY, Song YY, Ma JF, et al. Gene polymorphisms and risk of adult early-onset ischemic stroke: A meta-analysis. Thromb Res 2009;124:619–24.
   PubMed Web of Science ®Google Scholar
• Sazci A, Ergul E, Tuncer N, et al. Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull 2006;71:45–50.
   PubMed Web of Science ®Google Scholar
• Kang S, Zhao XX, Liu LL, et al. Association of the C677T Polymorphism in the MTHFR Gene with Hemorrhagic Stroke: a Meta-Analysis. Genet Test Mol Biomarkers 2013;17:412–7.
   PubMed Web of Science ®Google Scholar
• Sabino A1, Fernandes AP, Lima LM, et al. Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease. J Thromb Thromboly 2009; 27:82–7.
   PubMed Web of Science ®Google Scholar
• Xu XW, Li JJ, Sheng WL, et al. Meta-analysis of genetic studies from journals published in china of ischemic stroke in the Han Chinese population. Cerebrovasc Dis 2008;26:48–62.
   Google Scholar
• Yu HH, Zhang WL, Shi JP. Relationship between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility of ischemic stroke: a meta-analysis. Zhonghua Yi Xue Za Zhi. 2011;91:2060–4.
   PubMedGoogle Scholar
• Li PP, Qin C. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis. Gene 2014;359–64.
   PubMed Web of Science ®Google Scholar
• Ariyaratnam R, Casas JP, Whittaker J, et al. Genetics of ischemic stroke among persons of non-European descent: a meta-analysis of eight genes involving approximately 32,500 individuals. PLoS Med 2007; 4:728–36.
   Web of Science ®Google Scholar
• Munafo MR, Flint J. Meta-analysis of genetic association studies. Trends Genet 2004;20:439–44.
   PubMed Web of Science ®Google Scholar
• Yagil Y, Yagil C. Candidate genes, association studies and haplotype analysis in the search for the genetic basis of hypertension. J Hypertens 2004;22:1255–8.
   PubMed Web of Science ®Google Scholar
• Hassan A, Gormley K, O'Sullivan M, et al. Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke 2004;35:654–9.
   PubMed Web of Science ®Google Scholar