153
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson's disease: a pilot study

, &
Pages 526-530 | Received 23 Aug 2014, Accepted 10 Nov 2014, Published online: 18 Dec 2014

References

  • Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson's disease. Mov Disord 2009;24(14):2076–80.
  • Gomez-Esteban JC, Zarranz JJ, Tijero B, et al. Restless legs syndrome in Parkinson's disease. Mov Disord 2007;22(13):1912–6.
  • Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59(3):421–4.
  • Tan EK, Lum SY, Wong MC. Restless legs syndrome in Parkinson's disease. J Neurol Sci 2002;196(1–2):33–6.
  • Kumar S, Bhatia M, Behari M. Sleep disorders in Parkinson's disease. Mov Disord 2002;17(4):775–81.
  • Angelini M, Negrotti A, Marchesi E, et al. A study of the prevalence of restless legs syndrome in previously untreated Parkinson's disease patients: absence of co-morbid association. J Neurol Sci 2011;310(1–2):286–8.
  • Gjerstad M, Tysnes O, Larsen J. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 2011;77(22):1941–6.
  • Gao X, Schwarzschild MA, O'Reilly E, et al. Restless legs syndrome and Parkinson's disease in men. Mov Disord 2010;25:2654–7.
  • Shin HY, Youn J, Yoon WT, et al. Restless legs syndrome in Korean patients with drug-naive Parkinson's disease: a nation-wide study. Parkinsonism Relat Disord. 2013;19(3):355–8.
  • Walters AS, LeBrocq C, Passi V, et al. A preliminary look at the percentage of patients with restless legs syndrome who also have Parkinson disease, essential tremor or Tourette syndrome in a single practice. J Sleep Res 2003;12(4):343–5.
  • Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003;61(3):304–9.
  • Connor JR, Wang XS, Allen RP, et al. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 2009;132(Pt 9):2403–12.
  • Friedman A, Galazka-Friedman J, Koziorowski D. Iron as a cause of Parkinson disease –a myth or a well established hypothesis? Parkinsonism Relat Disord 2009;15 Suppl 3:S212–4.
  • Martin WR, Wieler M, Gee M. Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Neurology 2008;70(16 Pt 2):1411–7.
  • Oakley AE, Collingwood JF, Dobson J, et al. Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 2007;68(21):1820–5.
  • Earley CJ, Barker, PB, Horska A, Allen RP. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 2006;7(5):458–61.
  • De Rosa A, Guacci A, Peluso S, et al. A case of restless leg syndrome in a family with LRRK2 gene mutation. Int J Neurosci. 2013;123(4):283–5.
  • Ben-Shachar D, Finberg JP, Youdim MB. Effect of iron chelators on dopamine D2 receptors. J Neurochem 1985;45(4):999–1005.
  • Zhao H, Zhu W, Pan T, et al. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res 2007;85(5):1065–76.
  • Qu S, Le W, Zhang X, et al. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol 2007;66(5):383–8.
  • Scatton B, Dennis T, L'Heureux R, et al. Degeneration of Noradrenergic and serotonergic but not dopaminerigic neurons in the lumbar spinal cord of parkinsonian patients. Brain Res 1986;380:181–5.
  • Wang X, Wiesinger J, Beard J, et al. Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome. J Neurol Sci 2004;220(1–2):59–66.
  • Ryu J, Lee M, Baik J. Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease. Park and Rel Disord 2011;17(3):201–201.
  • Kwon D, Seo W, Yoon H, et al. Transcranial brain sonography in Parkinson's disease with restless legs syndrome 2010;25(10):1373–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.