233
Views
16
CrossRef citations to date
0
Altmetric
Original Article

MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches

Pages 10-19 | Received 21 Sep 2014, Accepted 18 Nov 2014, Published online: 07 Jan 2015

References

  • Kim OJ, Hong SH, Jeon YJ, et al. Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans. Neurosci Lett 2013;533:11–6.
  • Arsene D, Gaina G, Balescu C, et al. C677T and A1298C methylenetetrahydropholate reductase (MTHFR) polymorphisms as factors involved in ischemic stroke. Rom J Morphol Embryol 2011;52:1203–7.
  • Goldstein LB, Adams R, Becker K, et al. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 2001;32:280–99.
  • Iso H, Naito Y, Sato S, et al. Serum triglycerides and risk of coronary heart disease among Japanese men and women. Am J Epidemiol 2001;153:490–9.
  • Dichgans N and Markus HS. Genetic association studies in stroke: methodological issues and proposed standard criteria. Stroke 2005;36:2027–31.
  • Shimozato M, Nakayama T, Yokoyama T, et al. A 15.5-year cohort study on risk factors for possible myocardial infarction and sudden death within 24 hours in a rural Japanese community. J Epidemiol 1996;6:15–22.
  • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–3.
  • Kostulas K, Crisby M, Huang WX, et al. A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis. Eur J Clin Invest 1998;28: 285–9.
  • Lopaciuk S, Bykowska K, Kwiecinski H, et al. Factor V Leiden, prothrombin gene G20210A variant, and methylenetetrahydrofolate reductase C677T genotype in young adults with ischemic stroke. Clin Appl Thromb Hemost 2001;7:346–50.
  • Madonna P, de Stefano V, Coppola A, et al. Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemic stroke. Stroke 2002;33:51–6.
  • Pezzini A, Grassi M, Del Zotto E, et al. Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis. J Neurol Neurosurg Psychiatry 2006;77:1150–6.
  • Moe KT, Woon FP, De Silva DA, et al. Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population. Eur J Neurol 2008;15:1309–14.
  • Shi C, Kang X, Wang Y, et al. The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke. Clin Chim Acta 2008;396:7–9.
  • Isordia-Salas I, Barinagarrementeria-Aldatz F, Leanos-Miranda A, et al. The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with idiopathic ischemic stroke in the young Mexican-Mestizo population. Cerebrovasc Dis 2010;29:454–9.
  • Giusti B, Saracini C, Bolli P, et al. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Thromb Haemost 2010;104:231–42.
  • Dragoni F, Chiarotti F, Rosano G, et al. Thrombophilic screening in young patients (< 40 years) with idiopathic ischemic stroke: a controlled study. Thromb Res 2011;127:85–90.
  • Supanc V, Sonicki Z, Vukasovic I, et al. The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals. J Stroke Cerebrovasc Dis 2014;23:e171–6.
  • Nakata Y, Katsuya T, Takami S, et al. Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease. Am J Hypertens 1998;11:1019–23.
  • Zheng YZ, Tong J, Do XP, et al. Prevalence of methylenetetrahydrofolate reductase C677T and its association with arterial and venous thrombosis in the Chinese population. Br J Haematol 2000;109:870–4.
  • Zhang G, Dai C. Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases. Thromb Res 2001;104:187–95.
  • Wu Y, Tomon M, Sumino K. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke: sex difference in Japanese. Kobe J Med Sci 2001;47:255–62.
  • Yingdong Z, Zhigang Z, Yang L. Association of plasma homocysteine level and N5,N10-methylenetetrahydrofolate reductase gene polymorphism with cerebral infarction. Chin Med Sci J 2002;17:231–5.
  • Li Z, Sun L, Zhang H, et al. Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China. Stroke 2003;34:2085–90.
  • Choi BO, Kim NK, Kim SH, et al. Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions. Thromb Res 2003; 111:39–44.
  • Ucar F, Sonmez M, Ovali E, et al. MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population. Am J Hematol 2004;76:40–3.
  • Szolnoki Z and Melegh B. Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis. Curr Med Chem 2006;13:1627–34.
  • Kawamoto R, Kohara K, Oka Y, et al. An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke. J Stroke Cerebrovasc Dis 2005;14:67–74.
  • Linnebank M, Montenarh M, Kolsch H, et al. Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study. Eur J Neurol 2005;12:614–8.
  • Gao X, Yang H, ZhiPing T. Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke. Neurosci Lett 2006;398:172–7.
  • Sazci A, Ergul E, Tuncer N, et al. Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull 2006;71: 45–50.
  • Marie SK, Shinjo S K, Oba-Shinjo S M, et al. Methylenetetrahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in a Brazilian population. Clinics (Sao Paulo) 2007;62:295–300.
  • Li CM, Zhang C, Lu X L, et al. [Association between angiotensin-converting enzyme and polymorphisms of N5, N10-methylenetetrahydrofolic acid reductase gene in patients with ischemic stroke]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007;29:359–63.
  • Goracy I, Cyrylowski L, Kaczmarczyk M, et al. C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects. J Appl Genet 2009;50:63–7.
  • Sabino A, Fernandes A P, Lima L M, et al. Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease. J Thromb Thrombolysis 2009;27:82–7.
  • Sun JZ, Xu Y, Lu H, et al. Polymorphism of the methylenetetrahydrofolate reductase gene association with homocysteine and ischemic stroke in type 2 diabetes. Neurol India 2009;57:589–93.
  • Al-Allawi NA, Avo AS, Jubrael JM. Methylenetetrahydrofolate reductase C677T polymorphism in Iraqi patients with ischemic stroke. Neurol India 2009;57:631–5.
  • They-They TP, Nadifi S, Rafai M A, et al. Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes. Acta Neurol Scand 2011;123:105–10.
  • Mejia Mohamed EH, Tan K S, Ali J M, et al. TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients. Ann Acad Med Singapore 2011;40:186–91.
  • Somarajan BI, Kalita J, Mittal B, et al. Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population. J Neurol Sci 2011;304:67–70.
  • Usacheva MA, Nasedkina TV, Ikonnikova A, et al. [Association study of renin-angiotensin system genes and hemostasis system genes with ischemic stroke among Russians of Central Russia]. Mol Biol (Mosk) 2012;46:214–23.
  • Fekih-Mrissa N, Mrad M, Klai S, et al. Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients. J Stroke Cerebrovasc Dis 2013;22:465–9.
  • Huang Y, Zhao YY, and Li S. [Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]. Zhonghua Yi Xue Za Zhi 2002;82:119–22.
  • Morita H, Kurihara H, Tsubaki S, et al. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vasc Biol 1998;18:1465–9.
  • Ou W, Liu X, Shen Y, et al. Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals. PLoS One 2014;9:e105516.
  • Kang SS, Wong PW, Bock HG, et al. Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. Am J Hum Genet 1991;48:546–51.
  • Li P, Qin C Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to ischemic stroke: a meta-analysis. Gene 2014;535:359–64.
  • Levin L, PNA member Lee Levin: an entrepreneurial profile. Interview by Kimberley Jackson. Pa Nurse 1991;46:10–11.
  • Cotlarciuc I, Malik R, Holliday EG, et al. Effect of genetic variants associated with plasma homocysteine levels on stroke risk. Stroke 2014;45:1920–4.
  • Jeon SB, Kang DW, Kim JS, et al. Homocysteine, small-vessel disease, and atherosclerosis: an MRI study of 825 stroke patients. Neurology 2014;83:695–701.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.