Association between PDE4D gene and ischemic stroke: recent advancements

References

• Worrall BB, Mychaleckyj JC. PDE4D and stroke: a real advance or a case of the Emperor's new clothes? Stroke 2006;37:1955–7.
   PubMed Web of Science ®Google Scholar
• Gretarsdottir S, Thorleifsson G, Reynisdottir ST, et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nature Genet 2003;35:131–8.
   PubMed Web of Science ®Google Scholar
• Essayan DM. Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol 2001;108:671–80.
   PubMed Web of Science ®Google Scholar
• Kim D, Rybalkin SD, Pi X, et al. Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation 2001;104:2338–43.
   PubMed Web of Science ®Google Scholar
• Kim D, Aizawa T, Wei H, et al. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol 2005;38:175–84.
   PubMed Web of Science ®Google Scholar
• Muller T, Engels P, Fozard JR. Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition. Trends Pharmacol Sci 1996;17:294–8.
   PubMed Web of Science ®Google Scholar
• N´emoz G, Zhang R, Sette C, Conti M. Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells. FEBS Lett 1996;384:97–102.
   PubMed Web of Science ®Google Scholar
• Peter D, Jin SLC, Conti M, et al. Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D. J Immunol 2007;178:4820–31.
   PubMed Web of Science ®Google Scholar
• Liu H, Maurice DH. Phosphorylation-mediated activation and translocation of the cyclic AMP- specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases: a potential mechanism allowing for the coordinated regulation of PDE4D activity and targeting. J Biol Chem 1999;274:10557–65.
   PubMed Web of Science ®Google Scholar
• Cai X. Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies. Expert Rev Cardiovas Ther 2006;4:789–800.
   PubMedGoogle Scholar
• Koyama H, Bornfeldt KE, Fukumoto S, Nishizawa Y. Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation. J Cell Physiol 2001;186:1–10.
   PubMed Web of Science ®Google Scholar
• Li N, He Z, Xu J, et al. Association of PDE4D and IL-1 gene polymorphism with ischemic stroke in a Han Chinese population. Brain Res Bull 2010;81:38–42.
   PubMed Web of Science ®Google Scholar
• Munshi A, Babu MS, Kaul S, et al. Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population. J Neurol Sci 2009;285:142–5.
   PubMed Web of Science ®Google Scholar
• Matsushita T, Kubo M, Yonemoto K, et al. Lack of association between variations of PDE4D and ischemic stroke in the Japanese population. Stroke 2009;40:1245–51.
   PubMed Web of Science ®Google Scholar
• Kostulas K, Gretarsdottir S, Kostulas V, et al. PDE4D and ALOX5AP genetic variants and risk for Ischemic cerebrovascular disease in Sweden. J Neurol Sci 2007;263:113–7.
   PubMed Web of Science ®Google Scholar
• Song Q, Cole JW, O'Connell JR, et al. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the stroke prevention in young women study. Hum Mol Genet 2006;15:2468–78.
   PubMed Web of Science ®Google Scholar
• Woo D, Kaushal R, Kissela B, et al. Association of phosphodiesterase 4D with ischemic stroke: a population-based case control study. Stroke 2006;37:371–6.
   PubMed Web of Science ®Google Scholar
• Lohmussaar E, Gschwendtner A, Mueller JC, et al. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 2005;36:731–6.
   PubMed Web of Science ®Google Scholar
• Bevan S, Porteous L, Sitzer M, Markus HS. Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. Stroke 2005;36:949–53.
   PubMed Web of Science ®Google Scholar
• Munshi A, Kaul S. Stroke genetics–focus on PDE4D gene. Int J Stroke 2008;3:188–92.
   PubMed Web of Science ®Google Scholar
• Liu K, Wang JW, Yu ZP, et al. Association of study between PDE4D gene polymorphism and ischemic stroke. Beijing Da Xue Xue Bao 2013;45:359–63.
   PubMedGoogle Scholar
• Shao M, Yi X, Chi L, et al. Ischemic stroke risk in a southeastern Chinese population: insights from 5-lipoxygenase activating protein and phosphodiesterase 4D single-nucleotide polymorphisms. J Formosan Med Assoc 2015;114:422–9.
   PubMed Web of Science ®Google Scholar
• He Y, Yang DZ, Yu H, et al. Genetic variants of phosphodiesterase 4D gene are associated with an enhanced risk for ischemic stroke in young Chinese population. Neurol India 2013;61:21–5.
   PubMed Web of Science ®Google Scholar
• He Y, Bai JY, Song B, et al. Sex-dependent association of phosphodiesterase 4D gene polymorphisms with ischemic stroke in Henan Han population. Chin Med J 2012;125:2255–9.
   PubMed Web of Science ®Google Scholar
• Zhao J, Wang X, Xu J, et al. Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese. Acta Biochim Biophys Sin 2012;44:1023–30.
   Google Scholar
• Xue H, Wang H, Song X, et al. Phosphodiesterase 4D gene polymorphism is associated with ischaemic and haemorrhagic stroke. Clin Sci 2009;116:335–40.
   PubMed Web of Science ®Google Scholar
• Lövkvist H, Olsson S, Höglund P, et al. A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene. Eur J Hum Genet 2012;20:783–9.
   PubMed Web of Science ®Google Scholar
• Lövkvist H, Smith JG, Luthman H, et al. Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region. Eur J Hum Genet 2008;16:1117–25.
   PubMed Web of Science ®Google Scholar
• Avdonina MA, Nasedkina TV, Ikonnikova Alu, et al. Association study of polymorphic markers of F12, PON1, PON2, NOS2, PDE4D, HIF1a, GPIba, CYP11B2 genes with ischemic stroke in Russian patients. Zh Nevrol Psikhiatr Im S S Korsakova 2012;112:51–4.
   PubMedGoogle Scholar
• Munshi A, Roy S, Thangaraj K, et al. Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes. Gene 2012;506:31–5.
   PubMed Web of Science ®Google Scholar
• Kalita J, Somarajana BI, Kumara B, et al. Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic stroke. Dis Markers 2011;31:191–7.
   PubMed Web of Science ®Google Scholar
• Milton AG, Aykanat VM, Hamilton-Bruce MA, et al. Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort. Int J Stroke 2011;6:480–6.
   PubMed Web of Science ®Google Scholar
• Bondarenko EA, Mokan EI, Barbakar NI, et al. Analysis of the polymorphic variants of the PDE4D gene in patients with acute stroke in the Moldavian population. Mol Gen Mikrobiol Virusol 2011;2:5–7.
   PubMedGoogle Scholar
• Bondarenko EA, Tupitsyna TV, Slominski PA, et al. Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow. Genetika 2010;46:861–4.
   PubMedGoogle Scholar
• Skvortsova VI, Limborskaia SA, Shetova IM, et al. Association of cerebral stroke with a phosphodiesterase 4D (PDE4D) gene polymorphism in the Moscow population. Zh Nevrol Psikhiatr Im S S Korsakova 2011;111:3–7.
   PubMedGoogle Scholar
• Domingues-Montanari S, Fernández-Cadenas I, del Rio-Espinola A, et al. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. Cerebrovasc Dis 2010;29:528–37.
   PubMed Web of Science ®Google Scholar
• Liao YC, Lin HF, Guo YC, et al. Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis. BMC Med Genet 2010;11:93–101.
   PubMed Web of Science ®Google Scholar
• Kim MK, Kim JT, Choi SM, et al. Phosphodiesterase 4D gene and risk of noncardiogenic ischemic stroke in a Korean population. J Korean Med Sci 2009;24:307–10.
   PubMed Web of Science ®Google Scholar
• Quarta G, Stanzione R, Evangelista A, et al. Phosphodiesterase 4D and 5-lipooxygenase activating protein genes and risk of ischemic stroke in Sardinians. Eur J Hum Genet 2009;17:1448–53.
   PubMed Web of Science ®Google Scholar
• Munafo MR, Flint J. Meta-analysis of genetic association studies. Trends Genet 2004;20:439–44.
   PubMed Web of Science ®Google Scholar
• Yan Y, Luo X, Zhang J, et al. Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke. J Neurol Sci 2014;338:3–11.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhu R, Li L, et al. Genetic Polymorphism in PDE4D gene and risk of ischemic stroke in Chinese population: a meta-analysis. PLOS One 2013;8:e66374.
   PubMed Web of Science ®Google Scholar
• Yadav S, Hasan N, Marjot T, et al. Detailed analysis of gene polymorphisms associated with ischemic stroke in South Asians. PLOS One 2013;8:e57305.
   PubMed Web of Science ®Google Scholar
• Yoon D, Park SK, Kang D, et al. Meta-analysis of homogeneous subgroups reveals association between PDE4D gene variants and ischemic stroke. Neuroepidemiology 2011;36:213–22.
   PubMed Web of Science ®Google Scholar
• Xu X, Li X, Li J, et al. Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations. Neurogenetics 2010;11:327–33.
   PubMed Web of Science ®Google Scholar
• Bevan S, Dichgans M, Gschwendtner A, et al. Variation in the PDE4D gene and ischemic stroke risk: a systematic review and metaanalysis on 5200 cases and 6600 controls. Stroke 2008;39:1966–71.
   PubMed Web of Science ®Google Scholar
• He Z, He B, Behrle BL, et al. Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associatedwith blood brain barrier permeability: effect of age. ACS Chem Neurosci 2012;3:428–32.
   PubMed Web of Science ®Google Scholar
• Yang F, Liu S, Yu C, et al. PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells. Thromb Res 2012;129:750–3.
   PubMed Web of Science ®Google Scholar
• Yang F, Sumbria RK, Xue D, et al. Effects of PDE4 pathway inhibition in rat experimental stroke. J Pharm Pharm Sci 2014;17:362–70.
   PubMed Web of Science ®Google Scholar
• Liu L, Xu X, Li J, et al. Lentiviral-mediated shRNA silencing of PDE4D gene inhibits platelet-derived growth factor-induced proliferation and migration of rat aortic smooth muscle cells. Stroke Res Treat 2011;2011:1–7.
   Google Scholar
• Chen KC, Chang KW, Chen HY, Chen CY. Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? Mol Biosyst 2011;7:2711–9.
   PubMed Web of Science ®Google Scholar
• Chang TT, Chen KC, Chang KW, et al. In silico pharmacology suggests ginger extracts may reduce stroke risks. Mol Biosyst 2011;7:2702–10.
   PubMed Web of Science ®Google Scholar
• Kumar A, Sagar R, Kumar P, et al. Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design. BMC Neurol 2013;13:136–43.
   PubMed Web of Science ®Google Scholar
• Rosand J, Bayley N, Rost N, de Bakker Pi. Many hypotheses but no replication for the association between PDE4D and stroke.Nature Genet 2006;38:1091–2.
   PubMed Web of Science ®Google Scholar
• Reich D, Thangaraj K, Patterson N, et al. Reconstructing Indian population history. Nature 2009;461:489–94.
   PubMed Web of Science ®Google Scholar
• Newcombe PJ, Verzilli C, Casas JP, et al. Multilocus Bayesian meta-analysis of gene-disease associations. Am J Hum Genet 2009;84:567–80.
   PubMed Web of Science ®Google Scholar