138
Views
16
CrossRef citations to date
0
Altmetric
Original Articles

Elevated levels of cerebrospinal fluid S100B are associated with brain injury and unfavorable outcomes in children with central nervous system infections

, , , , &
Pages 1-9 | Received 27 Aug 2015, Accepted 19 Dec 2015, Published online: 25 Jan 2016

References

  • Namani S, Milenkovic Z, Koci B. A prospective study of risk factors for neurological complications in childhood bacterial meningitis. J Pediatr 2013;89(3):256–62.
  • Mallewa M, Vallely P, Faragher B, et al. Viral CNS infections in children from a malaria-endemic area of Malawi: a prospective cohort study. Lancet Glob Health 2013;1(3):e153–60.
  • DuBray K, Anglemyer A, LaBeaud AD, et al. Epidemiology, outcomes and predictors of recovery in childhood encephalitis: a hospital-based study. Pediatr Infect Dis J 2013;32(8):839–44.
  • Wong AM, Lin JJ, Toh CH, et al. Childhood encephalitis: relationship between diffusion abnormalities and clinical outcome. Neuroradiology 2015;57(1):55–62.
  • Sutter R, Kaplan PW, Cervenka MC, et al. Electroencephalography for diagnosis and prognosis of acute encephalitis. Clin Neurophysiol 2015;126(8):1524–31.
  • Teasdale G, Maas A, Lecky F, et al. The Glasgow coma scale at 40 years: standing the test of time. Lancet Neurol 2014;13(8):844–54.
  • Donato R, Sorci G, Riuzzi F, et al. S100B's double life: intracellular regulator and extracellular signal. Biochimica Biophys Acta 2009;1793(6):1008–22.
  • Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001;33(7):637–68.
  • Ahmad O, Wardlaw J, Whiteley WN. Correlation of levels of neuronal and glial markers with radiological measures of infarct volume in ischaemic stroke: a systematic review. Cerebrovasc Dis 2012;33(1):47–54.
  • Schmidt H, Gerber J, Stuertz K, et al. S100B in the cerebrospinal fluid – a marker for glial damage in the rabbit model of pneumococcal meningitis. Neurosci Lett 2010;475(2):104–7.
  • Rohlwink UK, Figaji AA. Biomarkers of brain injury in cerebral infections. Clin Chem 2014;60(6):823–34.
  • Bloomfield SM, McKinney J, Smith L, Brisman J. Reliability of S100B in predicting severity of central nervous system injury. Neurocrit Care 2007;6(2):121–38.
  • Serpero LD, Pluchinotta F, Gazzolo D. The clinical and diagnostic utility of S100B in preterm newborns. Clin Chim Acta 2015;444:193–8.
  • Chaves ML, Camozzato AL, Ferreira ED, et al. Serum levels of S100B and NSE proteins in Alzheimer's disease patients. J Neuroinflamm 2010;7(1):1–7.
  • Mercier E, Boutin A, Lauzier F, et al. Predictive value of S-100beta protein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and meta-analysis. BMJ 2013;346:f1757–72.
  • Gazzolo D, Grutzfeld D, Michetti F, et al. Increased S100B in cerebrospinal fluid of infants with bacterial meningitis: relationship to brain damage and routine cerebrospinal fluid findings. Clin Chem 2004;50(5):941–4.
  • Kepa L, Oczko-Grzesik B. Evaluation of cerebrospinal fluid S100B protein concentration in patients with purulent, bacterial meningitis - own observations. Przegl Epidemiol 2013;67(3):415–9, 525–8.
  • Hamed SA, Hamed EA, Zakary MM. Oxidative stress and S-100B protein in children with bacterial meningitis. BMC Neurol 2009;9(1):51–9.
  • Akhvlediani T, Bautista CT, Shakarishvili R, et al. Etiologic agents of central nervous system infections among febrile hospitalized patients in the country of Georgia. PLOS One. 2014;9(11):e111393–9.
  • Kelly C, Sohal A, Michael BD, et al. Suboptimal management of central nervous system infections in children: a multi-centre retrospective study. BMC Pediatr 2012;12(4):145–52.
  • Huttunen P, Lappalainen M, Salo E, et al. Differential diagnosis of acute central nervous system infections in children using modern microbiological methods. Acta Paediatrica 2009;98(8):1300–6.
  • Granerod J, Ambrose HE, Davies NWS, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis 2010;10(12):835–44.
  • Michael BD, Sidhu M, Stoeter D, et al. Acute central nervous system infections in adults – a retrospective cohort study in the NHS North West region. QJM 2010;103(10):749–58.
  • Glaser CA, Gilliam S, Schnurr D, et al. In search of encephalitis etiologies: diagnostic challenges in the California Encephalitis Project, 1998–2000. Clin Infect Dis 2003;36(6):731–42.
  • Chen JWY, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006;5(3):246–56.
  • Fiser DH, Long N, Roberson PK, et al. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med 2000;28(7):2616–20.
  • Spinella PC, Donoghue A, Rajendra A, et al. Cerebrospinal fluid levels of S-100beta in children and its elevation in pediatric meningitis. Pediatr Crit Care Med 2004;5(1):53–7.
  • Petzold A, Keir G, Lim D, et al. Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern. Brain Res Bull 2003;61(3):281–5.
  • Studahl M, Gunther G, Rosengren L. Serum S-100B protein levels in patients with herpes simplex encephalitis and tick-borne encephalitis – a marker of CNS damage during the initial stage of disease. J Neurol 2009;256(4):586–90.
  • Jonsson H, Johnsson P, Hoglund P, et al. Elimination of S100B and renal function after cardiac surgery. J Cardiothoracic Vascular Anesthesia 2000;14(6):698–701.
  • Grahn A, Hagberg L, Nilsson S, et al. Cerebrospinal fluid biomarkers in patients with varicella-zoster virus CNS infections. J Neurol 2013;260(7):1813–21.
  • Studahl M, Rosengren L, Gunther G, Hagberg L. Difference in pathogenesis between herpes simplex virus type 1 encephalitis and tick-borne encephalitis demonstrated by means of cerebrospinal fluid markers of glial and neuronal destruction.J Neurol 2000;247(8):636–42.
  • Unden J, Christensson B, Bellner J, et al. Serum S100B levels in patients with cerebral and extracerebral infectious disease. Scand J Infect Dis 2004;36(1):10–3.
  • Petzold A, Groves M, Leis AA, et al. Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile virus infection. Muscle Nerve 2010;41(1):42–9.
  • Sellner J, Davies NW, Howard RS, Petzold A. Neurofilament heavy chain as a marker of neuroaxonal pathology and prognosis in acute encephalitis. Eur J Neurol 2014;21(6):845–50.
  • Tsukahara H, Fujii Y, Matsubara K, et al. Prognostic value of brain injury biomarkers in acute encephalitis/encephalopathy. Pediatr Int 2013;55(4):461–4.
  • Blennow M, Savman K, Ilves P, et al. Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr 2001;90(10):1171–5.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.