Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke

References

• Moonis M, Kane K, Schwiderski U, et al. HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke 2005;36:1298–300.
   PubMed Web of Science ®Google Scholar
• Àlvarez-Sabìn J, Huertas R, Quintana M, et al. Prior statin use may be associated with improved stroke outcome after tissue plasminogen activator. Stroke 2007;38:1076–8.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang C, Jiang H, et al. Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 2005;25:281–90.
   PubMed Web of Science ®Google Scholar
• Cappellari M, Deluca C, Tinazzi M, et al. Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study. J Neurol Sci 2011;308(1–2):128–34.
   PubMed Web of Science ®Google Scholar
• Ní Chróinín D, Callaly, EL, Duggan J, et al. Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin population stroke study. Stroke 2011;42(4):1021–9.
   PubMed Web of Science ®Google Scholar
• Sargento-Freitas J, Pagola J, Rubiera M, et al. Preferential effect of premorbid statins on atherothrombotic strokes through collateral circulation enhancement. Eur Neurol 2012;68(3):171–6.
   PubMed Web of Science ®Google Scholar
• Cui X, Chopp M, Shehadah A, et al. Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth. Cell Transplant 2012;21(5):845–56.
   PubMed Web of Science ®Google Scholar
• Hong KS, Lee JS. Statins in acute ischemic stroke: a systematic review. J Stroke 2015;17(3):282–301.
   PubMed Web of Science ®Google Scholar
• Wang QM, Wei Y, Zheng Y, Waeber C. Efficacy of combined atorvastatin and sildenafil in promoting recovery after ischemic stroke in mice. Am J Phys Med Rehabil 2013;92:143–50.
   PubMed Web of Science ®Google Scholar
• Lakhan SE, Bagchi S, Hofer M. Statins and clinical outcome of acute ischemic stroke: a systematic review. Int Arch Med 2010;3:22.
   PubMedGoogle Scholar
• Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011;10:209–19.
   PubMed Web of Science ®Google Scholar
• Kleim JA, Jones TA, Schallert T. Motor enrichment and the induction of plasticity before or after brain injury. Neurochem Res 2003;28:1757–69.
   PubMed Web of Science ®Google Scholar
• Bekinschtein P, Cammarota M, Katche C, et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA 2008;105:2711–6.
   PubMed Web of Science ®Google Scholar
• Wu H, Lu D, Jiang H, et al. Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 2008;25:130–9.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Huang S, Wang B, et al. Atorvastatin and whisker stimulation synergistically enhance angiogenesis in the barrel cortex of rats following focal ischemia. Neurosci Lett 2012;525:135–9.
   PubMed Web of Science ®Google Scholar
• Laske C, Stransky E, Leyhe T, et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 2007;41(5):387–94.
   PubMed Web of Science ®Google Scholar
• Poli, A. Atorvastatin: pharmacological characteristics and lipid-lowering effects. Drugs 2007;67(Suppl 1):3–15.
   PubMed Web of Science ®Google Scholar
• Jia W, Zhou L. Effect of 20 mg/day atorvastatin: recurrent stroke survey in Chinese ischemic stroke patients with prior intracranial hemorrhage. J Clin Neurol 2013;91:39–43.
   Google Scholar
• Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006;355(6):549–59.
   PubMed Web of Science ®Google Scholar
• Sadeghi R, Asadpour-Piranfar M, Asadollahi M, et al. The effects of different doses of atorvastatin on serum lipid profile, glycemic control, and liver enzymes in patients with ischemic cerebrovascular accident. ARYA Atheroscler 2014;10(6): 298–304.
   PubMedGoogle Scholar
• Vergouwen MD, Hann RJ, Vermeulen M, et al. Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease. Stroke 2008;39(2):497–502.
   PubMed Web of Science ®Google Scholar
• Liao JK. Safety and efficacy of statins in Asians. Am J Cardiol 2007;99(3):410–4.
   PubMed Web of Science ®Google Scholar
• Adams HJ, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial.Toast. Trial of org 10172 in acute stroke treatment. Stroke 1993;24:35–41.
   PubMed Web of Science ®Google Scholar
• Kuhn HG, Palmer TD, Fuchs E. Adult neurogenesis: a compensatory mechanism for neuronal damage. Eur Arch Psychiatry Clin Neurosci 2001;251:152–8.
   PubMed Web of Science ®Google Scholar
• Parent JM. Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist 2003;9:261–72.
   PubMed Web of Science ®Google Scholar
• Kreuzberg M, Kanov E, Timofeev O, et al. Increased subventricular zone-derived cortical neurogenesis after ischemic stroke. Exp Neurol 2010;226(1):90–9
   PubMed Web of Science ®Google Scholar
• Mason JC, Ahmed Z, Mankoff R, et al. Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. Circ Res 2002;91:696–703.
   PubMed Web of Science ®Google Scholar
• Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011;10: 209–19.
   PubMed Web of Science ®Google Scholar
• Tanaka J, Horiike Y, Matsuzaki M, et al. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 2008;319(5870):1683–7.
   PubMed Web of Science ®Google Scholar
• Horch HW, Katz LC. BDNF release from single cells elicits local dendritic growth in nearby neurons. Nat Neurosci 2002;5(11):1177–84.
   PubMed Web of Science ®Google Scholar
• Kang H, Schuman EM. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 1995;267(5204):1658–62.
   PubMed Web of Science ®Google Scholar
• Kalayci R, Kaya M, Elmas I, et al. Effects of atorvastatin on blood–brain barrier permeability during L-NAME hypertension followed by angiotensin-II in rats. Brain Res 2005;1042:184–93.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang ZG, Li Y, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003;53:743–51.
   PubMed Web of Science ®Google Scholar
• Miyake K, Yamamoto W, Tadokoro M, et al. Alterations in hippocampal GAP-43, BDNF, and L1 following sustained cerebral ischemia. Brain Res 2002;935:24–31.
   PubMed Web of Science ®Google Scholar
• Cui X, Chopp M, Zacharek A, et al. Endothelial nitric oxide synthase regulates white matter changes via the BDNF/TrkB pathway after stroke in mice. PLOS One 2013;8(11):e80358.
   PubMed Web of Science ®Google Scholar