Development of stem cell-based therapies for Parkinson's disease

References

• Lang AE, Lozano AM. Parkinson's disease. First of two parts. N Engl J Med 1998;339:1030–43.
   PubMed Web of Science ®Google Scholar
• Lang AE, Lozano AM. Parkinson's disease. Second of two parts. N Engl J Med 1998;339:1044–53.
   PubMed Web of Science ®Google Scholar
• Meissner WG, Frasier M, Gasser T. Priorities in Parkinson's disease research. Nat Rev Drug Discov 2011;10(5):377–93.
   PubMed Web of Science ®Google Scholar
• Dunnett SB, Björklund A, Schmidt RH, et al. Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensions. Acta Physiol Scand Suppl 1983;522:39–47.
   PubMedGoogle Scholar
• Freund TF, Bolam JP, Björklund A, et al. Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical study. J Neurosci 1985;5(3):603–16.
   PubMed Web of Science ®Google Scholar
• Annett LE, Torres EM, Clarke DJ, et al. Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age. Cell Transplant 1997;6(6):557–69.
   PubMed Web of Science ®Google Scholar
• Brundin P, Strecker RE, Lindvall O, et al. Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease. Ann N Y Acad Sci 1987;495:473–96.
   PubMed Web of Science ®Google Scholar
• Barker RA. Developing stem cell therapies for Parkinson's disease: waiting until the time is right. Cell Stem Cell 2014;15:540–42.
   Web of Science ®Google Scholar
• Horiguchi S, Takahashi J, Kishi Y. Neural precursor cells derived from human embryonic brain retain regional specificity. J Neurosci Res 2004;75(6):817–24.
   PubMed Web of Science ®Google Scholar
• Madhavan L, Daley BF, Paumier KL, Collier TJ. Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease. J Comp Neurol 2009;515:102–15.
   PubMed Web of Science ®Google Scholar
• Mochizuki H, Choong CJ, Yasuda T. The promises of stem cells: stem cell therapy for movement disorders. Parkinsonism Relat Disorders 2014;20(S1):S128–31
   Google Scholar
• Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produced neurons and astrocytes. J Neurosci 1992;12:4565–74
   PubMed Web of Science ®Google Scholar
• Fricker-Gates, RA, Gates MA. Stem cell-derived dopamine neurons for brain repair in Parksinson's disease. Regen Med 2010;5(2):267–78.
   PubMed Web of Science ®Google Scholar
• Redmond DE Jr, Bjugstad KB, Teng YD, et al. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci 2007;104:12175–80.
   PubMed Web of Science ®Google Scholar
• Wakeman DR, Redmond DE Jr, Dodiya HB, et al. Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target. Stem Cells Transl Med 2014;3(6):692–701.
   PubMed Web of Science ®Google Scholar
• Chen S, Yang C, Hao F, et al. Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of Parkinsonism. Exp Neurol 2014;261:87–96
   PubMed Web of Science ®Google Scholar
• Müller J, Ossig C, Greiner JF, et al. Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in Parkinsonian rats. Stem Cells Transl Med 2015;4(1):31–43.
   PubMed Web of Science ®Google Scholar
• Courtois ET, Castillo CG, Seiz EG, et al. In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by BCL-XL. J Biol Chem. 2010;285(13):9881–9897.
   Google Scholar
• O’ Keefe FE, Scott SA, Tyers P, et al. Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parksinson's disease. Brain 2008;131:630–41.
   PubMed Web of Science ®Google Scholar
• Tan X, Zhang L, Qin J, et al. Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats. Int J Dev Neurosci 2013;31(1):82–7.
   PubMed Web of Science ®Google Scholar
• Tan X, Zhang L, Zhu H, et al. Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons. Neurosci Lett 2014;571:23–8.
   PubMed Web of Science ®Google Scholar
• Wu J, Sheng C, Liu Z, et al. Lmx1a enhances the effect of iNSCs in a PD model. Stem Cell Res 2015;14(1):1–9.
   PubMed Web of Science ®Google Scholar
• Parmar M,, Li M. Early specification of dopaminergic phenotype during ES cell differentiation. BMC Dev Biol 2007;7(1):86. doi:10.1186/1471-213X-7-86
   PubMed Web of Science ®Google Scholar
• Cooper O, Hargus G, Deleidi M, et al. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci 2010;45(3):258–66.
   PubMed Web of Science ®Google Scholar
• Baizabal JM,, Covarrubias L. The embryonic midbain directs neuronal specification of embryonic stem cells at early stages of differentiation. Dev Biol 2009;325(1):49–59.
   PubMed Web of Science ®Google Scholar
• Shimada H, Yoshimura N, Tsuji, A, Kunisada T. Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20. J Biosci Bioeng 2009;107(4):447–54.
   PubMed Web of Science ®Google Scholar
• Cai J, Donaldson A, Yang M, et al. The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model. Stem Cells 2009;27:220–9.
   PubMed Web of Science ®Google Scholar
• Hong S, Chung S, Leung K, et al. Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells. Stem Cells Dev 2014;23(5):477–87.
   PubMed Web of Science ®Google Scholar
• Kriks S,, Studer L. Protocols for generating ES cell-derived dopamine neurons. Adv Exp Med Biol 2008;651:101–11.
   Web of Science ®Google Scholar
• Chung S, Moon JI, Leung A, et al. ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci USA 2011;108(23):9703–8.
   PubMed Web of Science ®Google Scholar
• Kriks S, Shim JW, Piao J, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011;480(7378):547–51.
   PubMed Web of Science ®Google Scholar
• Kirkeby A., Grealish S., Wolf DA., et al. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep 2012;1(6):703–14.
   PubMed Web of Science ®Google Scholar
• Wakeman DR, Weiss S, Sladek JR, et al. Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates. Cell Transplant 2014;23(8):981–94.
   PubMed Web of Science ®Google Scholar
• Grealish S, Diguet E, Kirkeby A, et al. Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease. Cell Stem Cell 2014;15(5):653–65.
   PubMed Web of Science ®Google Scholar
• Lindvall O, Kokaia Z. Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci 2009;30(5):260–267.
   PubMed Web of Science ®Google Scholar
• Martinez-Serrano A,, Liste I. Recent progress and challenges for the use of stem cell derivatives in neuron replacement therapy for Parkinson's disease. Future Neurol 2010;5(2):161–5.
   Google Scholar
• Wernig M, Zhao JP, Pruszak J. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci USA 2008;105:5856–61.
   PubMed Web of Science ®Google Scholar
• Arenas E. Towards stem cell replacement therapies for Parkinson's disease. Biochem Biophys Res Commun 2010;396:152–56.
   PubMed Web of Science ®Google Scholar
• Huangfu D, Osafune K, Maehr R. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008;26:1269–75.
   PubMed Web of Science ®Google Scholar
• Han F, Wang W, Chen B, et al. Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Cytotherapy 2015;17(5):665–79.
   PubMed Web of Science ®Google Scholar
• Hallett PJ, Deleidi M, Astradsson A, et al. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell 2015;16(3):269–74.
   PubMed Web of Science ®Google Scholar
• Doi D, Samata B, Katsukawa M, et al. Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation. Stem Cell Rep 2014;2:337–50.
   PubMed Web of Science ®Google Scholar
• Nguyen HN, Byers B, Cord B, et al. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 2011;8:267–80.
   PubMed Web of Science ®Google Scholar
• Cooper O, Seo H, Andrabi S, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med 2012;4:141ra190.
   Web of Science ®Google Scholar
• Imaizumi Y, Okada Y, Akamatsu W, et al. Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain 2012;5:35. doi:10.1186/1756-6606-5-35
   PubMed Web of Science ®Google Scholar
• Hargus G, Cooper O, Deleidi M, et al. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci USA 2010;107:15921–26.
   PubMed Web of Science ®Google Scholar
• Rhee YH, Ko JY, Chang MY, et al. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest 2011;121:2326–35.
   PubMed Web of Science ®Google Scholar
• Ross CA,, Akimov SS. Human-induced pluripotent stem cells: potential for neurodegenerative diseases. Hum Mol Genet 2014;23(R1):R17–26
   PubMed Web of Science ®Google Scholar
• Chun C, LingJun R, LinZhao C, Lei X. Generation and application of human iPS cells. Chin Sci Bull 2009;54(1):9–13.
   Google Scholar
• Glavaski-Joksimovic A,, Bohn MC. Mesenchymal stem cells and neuroregeneration in Parkinson's disease. Exp Neurol 2013;247:25–38
   PubMed Web of Science ®Google Scholar
• Li Y, Chen J, Wang L, et al. Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinemouse model of Parkinson's disease. Neurosci Lett 2001;316:67–70.
   PubMed Web of Science ®Google Scholar
• Hellmann MA, Panet H, Barhum Y, et al. Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents. Neurosci Lett 2006;395:124–8.
   PubMed Web of Science ®Google Scholar
• Blandini F, Cova L, Armentero MT, et al. Transplantation of undifferentiated human mesenchymal stem cells protects against 6-hydroxydopamine neurotoxicity in the rat. Cell Transplant 2010;19:203–17.
   PubMed Web of Science ®Google Scholar
• Danielyan L, Schafer R, von Ameln-Mayerhofer A, et al. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Rejuvenation Res 2011;14:3–16.
   PubMed Web of Science ®Google Scholar
• Suzuki S, Kawamata J, Iwahara N, et al. Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats. Neurosci Lett 2015;584:276–81.
   PubMed Web of Science ®Google Scholar
• Park HJ, Lee PH, Bang OY, et al. Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease. J Neurochem 2008;107:141–51.
   PubMed Web of Science ®Google Scholar
• Offen D, Barhum Y, Levy YS, et al. Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease. J Neural Transm 2007;( Suppl):133–43.
   Web of Science ®Google Scholar
• Glavaski-Joksimovic A, Virag T, Chang QA, et al. Reversal of dopaminergic degeneration in a Parkinsonian rat following micrografting of human bone marrow-derived neural progenitors. Cell Transplant 2009;18:801–14.
   PubMed Web of Science ®Google Scholar
• McCoy MK, Martinez TN, Ruhn KA, et al. Autologous transplants of adipose-derived adult stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease. Exp Neurol 2008;210:14–29.
   PubMed Web of Science ®Google Scholar
• Mathieu P, Roca V, Gamba C, et al. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease. J Neuroimmunol 2012;246:43–50.
   PubMed Web of Science ®Google Scholar
• Xiong N, Zhang Z, Huang J, et al. VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther 2011;18:394–402.
   PubMed Web of Science ®Google Scholar
• Park S, Kima E, Kohb SE, et al. Dopaminergic differentiation of neural progenitors derived from placental mesenchymal stem cells in the brains of Parkinson's disease model rats and alleviation of asymmetric rotational behaviour. Brain Res 2012;1466:158–66.
   PubMed Web of Science ®Google Scholar
• Jiang W, Ni L, Sloan A, Song B. Tissue engineering and regenerative medicine, from and beyond the dentistry. Dentistry 2015;5:306. doi:10.4172/2161-1122.1000306
   Google Scholar
• Nesti C, Pardini C, Barachini S, et al. Human dental pulp stem cells protect mouse dopaminergic neurons against MPP+ or rotenone. Brain Res 2011;1367:94–102.
   PubMed Web of Science ®Google Scholar
• Ganz J, Arie I, Buch S, et al. Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-Parkinsonian rat model. PLoS One 2014;9(6):e100445. doi:10.1371/journal.pone.0100445
   Google Scholar
• Fujii H, Matsubara K, Sakai K, et al. Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats. Brain Res 2015;1613:59–72.
   PubMed Web of Science ®Google Scholar
• Toulouse A,, Sullivan AM. Progress in Parkinson's disease – where do we stand? Prog Neurobiol 2008;85:376–92.
   PubMed Web of Science ®Google Scholar