The Interaction of Phenothiazine Derivatives with Synaptosomal Membranes: the Use of Fluorescent Probes as an Indicator of Drug-Induced Conformational Perturbations

References

• Axelrod J. A., Whitbey L. G., Hertting G. Effect of psychotropic drugs on the uptake of H3-norepinephrine by tissues. Science 1961; 133: 383
   PubMed Web of Science ®Google Scholar
• Azzi A., Chance B., Radda G. K., Lee C. P. A fluorescence probe of energy-dependent structure changes in fragmented membranes. Proc. Natl. Acad. Sci. U.S. 1969; 62: 612
   PubMedGoogle Scholar
• Bodansky O., Schwartz M. K. Coorporative effects of 1-histidine on the activities of 5′-nucleotidase and alkaline phosphatase. J. Biol. Chem. 1963; 238: 3420
   PubMed Web of Science ®Google Scholar
• Brocklehurst J. R., Freedman R. B., Hancock D. J., Radda G. K. Membrane studies with polarity-dependent and excimer-forming fluorescent probes. Bicchem.J. 1970; 116: 721
   PubMed Web of Science ®Google Scholar
• Chance B., Azzi A., Mela L., Radda G., Vainio H. Local-anesthetic-induced changes of a membrane-bound fluorochrome. Link between ion uptake and membrane structure. Fed. European Biochem. Socs. Letters 1969; 3: 10
   PubMedGoogle Scholar
• Chance B., Mela L. Response of ANS to Ca++ binding mitochondrial membrane as affected by local anesthetic. Probes of Structure and Function of Macromolecules and Membranes, B. Chance, C. P. Lee, J. Blasie. Academic Press, New York 1971; Vol. I.: 261–264
   Google Scholar
• Christian S. T., Janetzko R. Comparative study of the interactions of the non-polar fluorescent ligand, l-anilino-8-naphthalene-sulfonic acid with butryl and acetylcholinesterase. Arch. Biochem. Biophys. 1971; 145: 169
   PubMedGoogle Scholar
• DeRobertis E., Alberici M., Arnaiz G., Rodriguez de Lores Azcurro J. M. Isolation of different types of synaptic membranes from the brain cortex. Life Sci. 1966; 5: 577
   PubMedGoogle Scholar
• De Robertis E., Lunt Glenys S., LaTorre, Jose L. Multiple binding sites for acetylcholine in a proteolipid from electric tissue. Mol. Pharm. 1971; 7: 97
   Google Scholar
• Dodd G. H., Radda G. K. 1-anilinonapthalene-8-sulfonate, a fluorescent conformational probe for glutamate dehydrogenase. Biochem. J. 1969; 114: 407
   PubMedGoogle Scholar
• Ehrenpreis S., Fleisch J. H., Mittage T. W. Approaches to the molecular nature of pharmacological receptors. Pharmacol. Reviews 1969; 21: 138
   Google Scholar
• Ellman G. L., Courtney K. D., Andres V., Jr., Featherstone R. M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961; 7: 88
   PubMed Web of Science ®Google Scholar
• Fortes P., George A., Hoffman J. F. Interactions of the fluorescent anion l-anilino-8-napthalenesulfonate with membrane changes in human red cell ghosts. J. Membrane Biol. 1971; 5: 154
   PubMedGoogle Scholar
• Freeman A. R., Spirtes M. A. Effect of some phenothiazine derivatives on the hemolysis of red blood cells in vitro. Biochem. Pharmacol. 1962; 11: 161
   PubMedGoogle Scholar
• Freeman A. R., Spirtes M. A. Effects of chlor-promazine on biological membranes–II. Chlorpro-mazine-induced changes in human erythrocytes. Biochem. Pharmacol. 1962; 12: 47
   Google Scholar
• Gitler C, Rubalcava B., Caswell A. H. Fluorescence changes of ethidium bromide on binding to erythrocyte and mitochondrial membranes. Biochem. Biophys. Acta 1969; 193: 479
   PubMed Web of Science ®Google Scholar
• Goldstein A., Lowney L. I., Pal B. K. Stereo-specific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. Proc. Nat. Acad. Sci. U.S. 1971; 68: 1742
   PubMed Web of Science ®Google Scholar
• Gomperts B., Sotck R. ANS fluorescence as an indicator of ionic interaction with membranes. Probes of Structure and Function of Macromolecules and Membranes, B. Chance, C. P. Lee, J. Blasie. Academic Press, New York 1971; Vol. I: 303–310
   Google Scholar
• Guth P. S., Spirtes M. A. The phenothiazine-tranquilizers: biochemical and biophysical actions. Int. Rev. Neurobiol. 1964; 7: 231
   PubMed Web of Science ®Google Scholar
• Holmes D. E., Piette L. H. Effects of phenothiazine derivatives on biological membranes: drug-induced changes in electron spin resonance spectra from spin-labeled erythrocyte ghost membranes. J. Pharmacol. Exp. Ther. 1970; 173: 78
   PubMedGoogle Scholar
• Iversen L. L. Inhibition of noradrenaline uptake by drugs. J. Pharm. Pharmacol. 1965; 17: 62
   PubMed Web of Science ®Google Scholar
• Karreman G., Isonberg I., Szent-Gydrgyi A. On the mechanisms of action of chlorpromazine. Science 1959; 130: 1191
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Rosenbough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265
   PubMed Web of Science ®Google Scholar
• Moore W. V., Wetlaufer D. B. Circular di-chroism of synaptosomal membranes. Interactions with neuropharmacological agents. J. Neurochem. 1971; 18: 1167
   PubMedGoogle Scholar
• Moran N. C, Butler W. M., Jr. The pharmacological properties of chlorpromazine sulfoxide, a major metabolite of chlorpromazine; a comparison with chlorpromazine. J. Pharmacol. Exp. Ther. 1965; 118: 328
   Google Scholar
• Nachmansohn D. Proteins in excitable membranes: their properties and function in bioelectricity are discussed. Science 1970; 168: 1059
   PubMedGoogle Scholar
• Radda G. K. Enzyme and membrane conformation in biochemical control. Biochem. J. 1971; 122: 13
   PubMedGoogle Scholar
• Rodriguez de Lores Arnaiz G., Alberici M., De Robertis E. Ultrastructural and enzymic studies of cholinergic and non-cholinergic synaptic membranes isolated from brain cortex. J. Neurochem. 1967; 14: 215
   PubMedGoogle Scholar
• Rubalcava B., Martinez de Munoz D., Gitler C. Interaction of fluorescent probes with membranes. I. Effect of ions on erythrocyte membranes. Biochemistry 1969; 8: 2742
   PubMedGoogle Scholar
• Sandberg H. E., Piettes L. H. EPR studies of psychotropic drug interactions at cell membranes. Aggressologie 1968; 9: 59
   PubMedGoogle Scholar
• Seeman P., Kwant W. O., Goldberg M., Chan-Wong M. Effects of ethanol and chlorpromazine on the passive membrane permeability to Na+. Biochim. Biophys. Acta 1971; 241: 349
   PubMedGoogle Scholar
• Spirtes M. A., Guth P. S. Effects of chlorpromazine on biological membranes–I. Chlorpro-mazine-induced changes in liver mitochondria. Biochem. Pharmacol. 1963; 22: 37
   Google Scholar
• Tasaki I., Watanabe A., Sandlin R., Camay L. Changes in fluorescence, turbidity, and birefringence associated with nerve excitation. Proc. Nat. Acad. Sci. U.S. 1968; 61: 883
   PubMed Web of Science ®Google Scholar
• Tjioe S., Haugaard N., Bianchi C. P. The effects of psychoactive agents on calcium uptake by preparations of rat brain mitochondria. J. Neurochem. 1971; 18: 2171
   PubMedGoogle Scholar
• Turner D. C., Brand L. Quantative estimation of protein binding site polarity. Fluorescence of N-arylaminonapthalene sulfonate. Biochem. 1968; 7: 3381
   PubMedGoogle Scholar
• Udenfriend S. VII. Central nervous system. Fluorescence Assay in Biology and Medicine, N. O. Kaplan, H. A. Scheraga. Academic Press, New York 1962; Vol. III: 434
   Google Scholar
• Wallach D. F. H., Ferber E., Selin D., Weidekamm E., Fischer H. The study of lipid-protein interactions in membranes by fluorescent probes. Biochem. Biophys. Acta. 1970; 203: 67
   PubMedGoogle Scholar
• Weissbach H., Smith T. E., Paly J. W., Witkop B., Udenfriend S. A rapid spectrophotometnc assay of monoamine oxidase based on the rate of disappearance of kynuramine. J. Biol. Chem. 1960; 235: 1160
   PubMed Web of Science ®Google Scholar