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Original Article

The Use of the Morris Water Maze in the Study of Memory and Learning

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Pages 29-69 | Received 27 Mar 1989, Published online: 07 Jul 2009

References

  • Anaducci L., Sorbi S., Albanese A. ChAT activity differs in the right and left human temporal lobes. Neurology 1981; 31: 799–805
  • Biegon A., Greenberg V., Segal M. Quantitative his tochemistry of brain acetylcholinesterase and learning rate in the aged rat. Neurobiology of Aging 1986; 7: 215–217
  • Brandeis R., Pittel Z., Lachman C., Heldman E., Luz S., Dachir S., Levy A., Hanin I., Fisher A. AF64A‐induced cholinotoxicity: Behavioral and biochemical correlates. Advances in behavioral biology: Alzheimer's and Parkinson's Diseases, A. Fisher, I. Hanin, C. Lachman. Plenum Press, New York and London 1986; Vol. 29: 469–477
  • Buresova O., Bolhuis J. J., Bures J. Differential effects of cholinergic blockade on performance of rats in the water tank navigation task and in a radial water maze. Behavioral Neuroscience 1986; 100: 476–482
  • Buresova O., Bures J. Radial maze as a tool for assessing the effect of drugs on the working memory of rats. Psychopharmacology 1982; 77: 268–271
  • Buresova O., Krekule I., Zahalka A., Bures J. On‐demand platform improves accuracy of the Morris water maze procedure. Journal of Neuroscience Methods 1985; 15: 63–72
  • Buresova O., Panakhova E., Bures J. Post‐trial flicker stimulation interferes with spatial memory in the Morris water maze. Neuroscience Letters 1985; 56: 359–363
  • Camp D. M., Thcrrien B. A., Robinson T. E. Spatial learning ability is related to an endogenous asymmetry in the nigrostriatal dopamine system in rats. Society for Neuroscience Abstracts 1981; 7: 149–60
  • Coscina D. V., Yehuda S., Dixon L. M., Kish S. J., Leprohan‐Greenwood C. E. Learning is improved by a soybean oil diet in rats. Life Science 1986; 38: 1789–1794
  • Clarke D. J., Gaye F. H., Niisson D. G., Bjorklund A. Grafted septal neurons form cholinergic synaptic connections in the dentate gyrus of behaviorally impaired aged rats. Journal of Comparative Neurology 1986; 252: 483–492
  • Dimattia B. V., Kesner R. P. Differential contribution of parietal cortex and hippocampal formation in the retention of a cognitive mapping. 1985, Dokla, C. P. J., Thal, J., Fitzgerald, L. W. (1986). Cholinesterase inhibitors as memory‐enhancing agents: Effects on passive avoidance and the Morris water task following nucleus basalis lesions. Society for Neuroscience Abstracts 12. 193
  • Dokla C. P. J., Thal J., Gardner E. L., Hann D., Passabet J. C., Fitzgerald L., Leiman M. Ibotenic acid (IBO) lesions of the NBM impair spatial‐reference memory in the Morris water task. Society for Neuroscience Abstracts 1985; 11: 101.6, 1985
  • Dunnett S. B., Toniolo G., Fine A., Ryan C. N., Bjorklund A., Iverson S. D. Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis II. Sensorimotor and learning impairments. Neuroscience 1985; 16: 787–797
  • Eckerman D. A., Gordon W. A., Edwards J. D., MacPhail R. C., Gaye M. I. Effects of scopolamine pentobarbital and amphetamine on radial arm maze performance in the rat. Pharmacology, Biochemistry and Behavior 1980; 12: 595–602
  • Fischer W., Wictorin K., Bjorklund A., Williams L. R., Varon S., Gage F. H. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 1987; 329: 65–68
  • Fisher A., Brandeis R., Karton I., Pittel Z., Sapir M., Dachir S., Levy A., Mizobe F., Heldman E. AF102B: A new Ml agonist with potential application in Alzheimer's disease (AD). Society for Neuroscience Abstracts 1987; 13: 184.12
  • Fisher A., Brandeis R., Karton I., Pittel Z., Sapir M., Grunfeld Y., Simon G., Rabinovitch I., Dachir S., Levy A., Heldman E. AE102B: A potential drug for the treatment of Alzheimer's disease (AD): Further characterization. Society for Neuroscience Abstracts 1988; 14: 365.10
  • Fisher A., Heldman E., Brandeis R., Karton Y., Pittel Z., Dachir S., Levy A., Mizobe F. AF102B: A novel putative Ml agonist as a candidate drug for treatment of Alzheimer's disease. Society for Neuroscience Abstracts 1986; 12: 191.1
  • Gage F. H., Bjorklund A. Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine‐sensitive mechanism. Journal of Neuroscience 1986; 6: 2837–2847
  • Gage F. H., Bjorklund A., Stenevi U. Intrahippocampal septax grafts ameliorate learning impairments in aged rats. Science 1984; 225: 533–536
  • Gage F. H., Dunnett S. B., Bjorklund A. Spatial learning and motor deficits in aged rats. Neurobiology of Aging 1984; 5: 43–48
  • Goodlett C. R., Valentino M. L., Morgrave P. J., Resnick O. Spatial cue utilization in chronically malnourished rats: Task specific learning deficits. Developmental Psychobiology 1986; 19: 1–15
  • Hagan J. J., Alpert J. E, Morris G. M., Iversen S. D. The effects of central catecholamine depletions on spatial learning in rats. Behavioral Brain Research 1983; 9: 83–104
  • Hagan J. J., Tweedie F., Morris R. G. M. Lack of task specificy and absence of posttraining effects of atropine on learning. Behavioral Neuroscience 1986; 100: 483–493
  • Holzhauer M. S., Bures J. Influence of electro‐convulsive shock and naloxone on acquisition and retention of a spatial navigation task. 1986, Hunter, A. J., Roberts, F., Tutty, C. A. (1986). Scopolamine impairs performance on the Morris water maze in both naive and trained rats. British Journal of Pharmacology 87, (Supple) 41P
  • Kolb B., Pittman K., Sutherland R. J., Whishaw I. Q. Dissociation of the contributions of the prefrontal cortex and dorsomedial thalamic nucleus to spatially guided behavior in the rat. Behavioral Brain Research 1982; 6: 365–378
  • Kolb B., Sutherland R. I., Whishaw I. Q. The relative contributions of cortical site and side in the control of praxic and spatial behavior. Society for Neuroscience Abstracts 1981; 7: 171.1
  • Kolb B., Sutherland R. J., Whishaw I. Q. A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats. Behavioral Neuroscience 1983; 97: 13–27
  • Kolb B., Sutherland R. J., Wishaw I. Q. Neonatal hemidecortication or frontal cortex ablation produces similar behavioral sparing but opposite effects on morphogenesis of remaining cortex. Behavioral Neuroscience 1983; 97: 154–158
  • Kolb B., Whishaw I. Q., Sutherland R. J. Behavioral and anatomical effects of adult vs. neonatal cerebral hemispherectomy. Society for Neuroscience Abstracts 1982; 8: 85.17
  • Levy A., Brandeis R., Dachir S., Luz S., Karton Y., Heldman E., Pittel Z., Fisher A. Reversal of AF64A‐induced memory impairment by cholinergic compounds. Society for Neuroscience Abstracts 1985; 11: 256.15
  • Levy A., Kluge P. B., Elsmore T. E. Radial arm maze performane of mice: Acquisition and atropine effects. Behavioral and Neural Biology 1983; 39: 229–240
  • Milner A. D., Lines C. R. Stimulus sampling and the use of distal visual cues in rats with lesions of the superior colliculus. Behavioral Brain Research 1983; 8: 387–401
  • Miyamoto M., Kato J., Narumi S., Nagoaka A. Characteristics of memory impairment following lesioning of the basal forebrain and medial septal nucleus in rats. Brain Research 1982; 419: 1931
  • Morris R. G. M. Spatial localization does not require the presence of local cues. Learning and Motivation 1981; 12: 239–260
  • Morris R. G. M. An attempt to dissociate spatial mapping and working memory theories of hippocampal function. Molecular Cellular and Behavioral Neurobiology of the Hippocampus, W. Siefert. Academic Press, London 1983; 405–432
  • Morris R. G. M. Modelling amnesia and the study of memory in animals. Trends in Neuroscience 1983; 6: 479–483
  • Morris R. G. M., Anderson E., Lynch G. S., Baudry M. Selective impairment of learning and blockade of long‐term potentiation by an N‐methyl‐O‐asparate receptor antagonist, AP5. Nature 1986; 319: 114–115
  • Morris R. G. M., Garrud J., Rawlins N. P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature (London) 1982; 297: 681–683
  • Morris R. G. M., Hagan J. J., Rawlings J. N. P. Allocentric spatial learning by hippocampectomized rats: A further test of the “spatial mapping” and “working memory” theories of hippocampal function. Quarterly Journal of Experimental Psychology 1986; 388: 365–369
  • Morris R. G. M., Schenk F. Dissociation between 'procedural' and 'declarative' aspects of spatial memory after recovery from retrohippocampal lesions by rats. Societv for Neuroscience Abstracts 1983; 9: 100.11
  • Nilsson O. G., Bjorklund A. Cue and place acquisition and performance following fimbria fornix transection and grafting of basal forebrain cholinergic neurons to the hippocampus. Neuroscience Letters 1985; 22: 530S, Suppl
  • Nilsson O. G., Shapiro M. L., Gage F. H., Olton D. S., Bjorklund A. Spatial learning and memory following fimbria‐fornix transection and grafting of fetal septal neurons to the hippocampus. Experimental Brain Research 1987; 67: 195–215
  • O'Keefe J., Nadel L. The hippocampus as a Cognitive Map. Clarendon Press, Oxford 1978
  • Olton D. S., Becker J. T., Handelman G. E. Hippocampus, space and memory. Behavioral Brain Science 1979; 2: 313–365
  • Panakhova E., Buresova O., Bures J. Persistence of spatial memory in the Morris water tank task. International Journal of Psychophysiology 1984; 2: 5–10
  • Panakhova E., Buresova P., Bures J. The effect of hypothermia on the rat's spatial memory in the water tank task. Behavioral and Neural Biolgoy 1984; 42: 191–196
  • Rapp P. R., Rosenberg R. A., Gallagher M. An evaluation of spatial information processing in aged rats. Behavioral Neuroscience 1987; 101: 3–12
  • Rudy J. W., Stadler‐Morris S. Development of interocular equivalence in rats trained on a distal‐cue navigation task. Behavioral Neuroscience 1987; 101: 141–143, 1987
  • Rudy J. W., Stadler‐Morris S., Albert P. Ontogeny of spatial navigation behaviors in the rat: dissociation of “proximal” and “distal”‐cue‐based behaviors. Behavioral Neuroscience 1987; 101: 62–73
  • Schenk F., Inglin F., Morris R. G. M. Place navigation in rats as a function of age. Society for Neuroscience Abstracts 1983; 9: 100.10
  • Schenk F., Morris R. G. M. Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Experimental Brain Research 1985; 58: 11–28
  • Skinner B. F. Contingencies of Reinforcement. Appleton, Century‐Crofts, New York 1969
  • Sutherland R. J., Dyck R. H. Place navigation by rats in a swimming pool. Canadian Journal of Psychology 1984; 38: 322–347
  • Sutherland R. J., Kolb B., Whishaw I. Q. On the contributions of cortical and subcortical systems to the acquisition and maintenance of spatial localization strategies. Society for Neuroscience Abstracts 1982; 8: 85.16
  • Sutherland R. J., Kolb B., Whishaw I. Q. Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat. Neuroscience Letters 1982; 31: 271–276
  • Sutherland R. J., Kolb B., Whishaw I. Q., Becker J. B. Cortical noradrenaline depletion eliminates sparing of spatial learning after neonatal frontal cortex damage in the rat. Neuroscience Letters 1982; 32: 125–130
  • Sutherland R. J., Linggard R. Being there: A novel demonstration of latent spatial learning. Behavioral and Neural Biology 1982; 35: 103–107
  • Sutherland R. J., Prusky G., Dyck R. H., Rodriguez A. Impaired spatial mapping after disruption of some rostrol connections of the hippocampal system in rats. Society for Neuroscience Abstracts 1985; 11: 244.7
  • Sutherland R. J., Whishaw I. Q., Kolb B. A behavioral analysis of spatial localization following electrolytic, kainate‐ or colchicine‐induced damage to the hippocampal formation in the rat. Behavioral Brain Research 1983; 7: 133–153
  • Sutherland R. J., Whishaw I. Q., Regehr J. C. Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat. Journal of Comparative Physiological Psychology 1982; 96: 563–573
  • Therrien B. A., Camp D. M., Robinson T. E. Sex differences in the effects of unilateral hippocampal lesions on spatial learning. Society for Neuroscience Abstracts 1982; 8: 85.13
  • Tolman E. C. Cognitive maps in rats and men. Psychological Review 1948; 55: 189–208
  • Vicedomini J. P., Isaac W., Lieber D., Nonneman A. J. Deficits in spatial learning ability following neonatal medial prefrontal/caudate nucleus lesions. Society for Neuroscience Abstracts 1982; 8: 15.15
  • Wade S. E., Maier S. F. A specific deficit in spatial learning is caused by respected but not acute treatment with a cholinergic agonist. Society for Neuroscience Abstracts 1985; 11: 114.1, 1985
  • Whishaw I. Q. Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool. Behavioral Neuroscience 1985; 99: 979–1005
  • Whishaw I. Q. Evidence for two types of place navigation. Electrical activity of the archcortex, G. Buzsaki, C. H. Vanderwolf. Hungarian Academy of Sciences, Budapest 1985; 233–253
  • Whishaw I. Q., Dunnett S. B. Dopamine depletion, stimulation or blockade in the rat disrupts navigation and locomotion dependent upon beacon or distal cues. Behavioral Brain Research 1985; 18: 11–29
  • Whishaw I. Q., Kolb B. Decortication abolishes place but not cue learning in rats. Behavioral Brain Research 1984; 11: 123–134
  • Whishaw I. Q., Mittleman G. Visits to starts, routes and places by rats (Rattus norvegicus) in swimming pool navigation tasks. Journal of Comparative Psychology 1987; 100: 422–431
  • Whishaw I. Q., O'Connor W. T., Dunnett S. B. Disruption of central cholinergic systems in the rat by basal forebrain lesions or atropine: Effects on feeding, sensorimotor, behavior, locomotor activity and spatial navigation. Behavioral Brain Research 1985; 17: 103–115
  • Whishaw I. Q., Sutherland R. J., Kolb B. Effects of neonatal forebrain noradrenaline depletion on recovery from brain damage: performance on a spatial navigation task as a function of age of surgery and postsurgical housing. Behavioral and Neural Biology 1986; 46: 285–307
  • Whishaw I. Q., Zaborowski J., Kolb B. Postsurgical enrichment aids adult hemidecorticate rats on a spatial navigation task. Behavioral and Neural Biology 1984; 42: 183–190
  • Yehuda S. Effects of alpha‐MSH, TRH and AVP on learning and memory, pain threshold and motor activity: Preliminary results. International Journal of Neuroscience 1987; 32: 703–709
  • Yehuda S., Carasso R. Effects of dietary fats on learning, pain threshold, thermoregulation and motor activity in rats: Internation with the length of feeding period. International Journal of Neuroscience 1987; 32: 919–925

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