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Original Article

Minamata Disease: What is a Keystone of its Molecular Mechanism? A biochemical theory on the nature of methyl mercury neurotoxicity

Dmitri A. Kuznetsov Laboratory of Biochemistry and Cell Biology, Medinvest Joint Venture, Bolshaya Spasskaya 4, Block 2, Moscow, USSR
Pages 1-51 | Received 02 Dec 1989, Published online: 07 Jul 2009

References (INTRODUCTION)

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References (Recent developments in biochemical methods for investigation of methyl mercury neurotoxicity)

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References (Methyl mercury and biological phosphorylation)

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  • Cheung M. K., Verity M. A. Experimental methyl mercury neurotoxicity: similar in vivo and in vitro perturbation of brain cell-free protein synthesis. Experimental Molecular Pathology 1984; 38: 230–242
  • Cheung M. K., Verity M. A. Experimental methyl mercury neurotoxicity: locus of mercurial inhibition of brain protein synthesis in vivo and in vitro. Journal of Neurochemistry 1985; 44: 1799–1808
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  • Kuznetsov D. A., Zavijalov N. V., Govorkov A. V., Ivanov A. A. Methyl mercury induced combined inhibition of ATP regeneration and protein synthesis in reticulocyte lysate cell-free translation system. Topxicology Letters 1986; 30: 267–271
  • Kuznetsov D. A., Zavijalov N. V., Govorkov A. V., Sibileva T. M. Methyl mercury induced nonselective blocking of phosphorylation processes as a possible cause of protein synthesis inhibition in vitro and in vivo. Toxicology Letters 1987; 36: 153–160
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  • Sarafian T. A., Verity M. A. Inhibition of RNA and protein synthesis in isolated cerebellar cells by in vitro and in vivo methyl mercury. Neurochemical Pathology 1985; 3: 27–39
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References (Methyl mercury and aminoacylation of tRNA)

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  • Kuznetsov D. A., Zavijalov N. V., Govorkov A. V., Sibileva(now Kuznetsova) T. M. Methyl mercury induced nonselective blocking of phosphorylation processes as a possible cause of protein synthesis inhibition in vitro and in vivo. Toxicology Letters 1987a; 36: 153–160
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References (Methyl mercury and messenger RNA turnover)

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References (Methyl mercury and mitochondrial protein synthesis)

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References (Conclusions)

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  • Kuznetsov D. A., Govorkov A. V., Zavijalov N. V., Sibileva T. M., Richter V., Drawczek J. A. Fast estimation of ATP/ADP ratio as a special step in pharmacological and toxicological studies using the cell-free translation systems. Journal of Biochemical and Biophysical Methods 1986b; 13: 53–56
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