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Original Article

Multiple Sclerosis: The Role of Puberty and the Pineal Gland in its Pathogenesis

Pages 209-225 | Received 15 Jun 1992, Published online: 07 Jul 2009

References

  • Abo T., Kawate T., Itoh K., Kumagai K. Studies on the bioperiodicity of the immune response. I. circadian rhythms of human T, B and K cell traffic in the peripheral blood. Journal of Immunology 1981; 126: 1360–1363
  • Acheson E. D. Epidemiology of multiple sclerosis. British Medical Bulletin 1977; 33: 9–14
  • Acheson E. D., Bachrach C. A., Wright F. M. Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation and other variables. Acta Psychiatrica Neurologica Scandinavica 1960; 35: 132–147, (suppl 147)
  • Adeloye A., Odeku E. L. Preliminary study of pineal gland in Nigerian African. Revue Neuro-psiquiatrique 1972; 1: 54–77
  • Adeloye A., Felson B. Incidence of normal pineal gland calcification in skull roengenograms of black and white Americans. American Journal of Radiology 1974; 122: 503–507
  • Alter M. Multiple sclerosis in the negro. Archives of Neurology 1962; 7: 83–91
  • Alter M., Okihiro M. When is multiple sclerosis acquired. Neurology 1971; 21: 1030–1036
  • Alter M., Halpern L., Kurland L. MS in Israel. Archives of Neurology 1962; 7: 253–263
  • Alter M., Kahana E., Lowenson R. Migration and risk of multiple sclerosis. Neurology 1978; 28: 1089–1093
  • Angeli A., Gatti G., Sartori M. L., DelPonte D., Garagnola R. Effect of exogenous melatonin on human natural killer (NK) cell activity: an approach to the immunomodulatory role of the pineal gland. The pineal gland and cancer, D. Gupta, A. Attanasio, R. J. Reiter. Brain Research Promotion, London 1988
  • Ansimov V. N., Loktionov A. S., Khavinson V. K., Morozov V. G. Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age. Mechanisms of Ageing and Development 1989; 49: 245–257
  • Antel J. P., Cashman N. R. Human retrovirus and multiple sclerosis. Mayo Clinic Proceedings 1991; 66: 752–755
  • Antel J. P., Arnason B. G. W., Reder A., Cashman N. Activated suppressor cell dysfunction in progressive multiple sclerosis. Journal of Immunology 1986; 137: 137–141
  • Arendt J. Melatonin assays in body fluids. Journal of Neural Transmission 1978; 13: 265–278, (suppl)
  • Arendt J., Wirz-Justice A., Bardtke J. Annual rhythm of serum melatonin in man. Neuroscience Letters 1977; 7: 327–330
  • Arendt J., Wirz-Justice A., Bradtke, Kornemark J. M. Long term studies on immunoreactive human melatonin. Annals of Clinical Biochemistry 1979; 16: 307–312
  • Arendt J., Labib M. H., Bojkowski C., Hanson S., Marks V. Melatonin assays in body fluids. Lancet 1989; 1: 1326
  • Armstrong S. M., Redman J. R. Melatonin: a chronobiotic with anti-aging properties. Medical Hypotheses 1991; 34: 300–309
  • Attanasio A., Borrelli P., Marini R., Cambiaso P., Cappo M., Gupta D. Serum melatonin in children with early and delayed puberty. Neuroendocrinology Letters 1983; 5: 387–392
  • Bamford C. R., Sibley W. A., Thies C. Seasonal variation of MS exacerbations in Arizona. Neurology 1983; 33: 1537–1544
  • Barlow J. S. Correlation of the geographic distribution of multiple sclerosis with cosmic rays. Acta Neurologica Scandinavica 1960; 25: 108–131, (suppl 147)
  • Barry R. J. Genetical factors in the etiology of multiple sclerosis. Acta Neurologica Scandinavica 1969; 45: 459–483
  • Bartsch C., Bartsch H., Jain A. K., Laumas K. R., Wetterberg L. Urinary melatonin levels in human breast cancer patients. Journal of Neural Transmission 1981; 52: 281
  • Bartsch C., Bartsch H., Fluchter S. H., Attanasio A., Das Gupta T. Evidence for a modulation of melatonin secretion in men with benign and malignant tumors of the prostate: relationship with pituitary hormones. Journal of Pineal Research 1988; 2: 121
  • Beck-Friis J., Von Rosen B. F., Kjellman D., Ljunggren J. G., Wetterberg L. Melatonin in relation to body measures. sex, age, season and use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology 1984; 9: 261–277
  • Berga S. L., Mortola J. F., Yen S. S. C. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea. Journal of Clinical Endocrinology and Metabolism 1988; 66: 242–744
  • Bindoni M., Jutisz M., Ribot G. Characterization and partial purification of a substance in the pineal gland which inhibits cell multiplication in vitro. Biochemistry, Biophysics Acta 1976; 437: 577–588
  • Birk K., Rudick R. Pregnancy and multiple sclerosis. Archives of Neurology 1986; 43: 719–726
  • Birk K., Ford C., Smeltzer S., Ryan D., Miller R., Rudick R. A. The clinical course of multiple sclerosis during pregnancy and the puerperium. Archives on Neurology 1990; 47: 738–742
  • Blask D. E. The pineal: an oncostatic gland. The pineal gland, R. J. Reiter. Raven Press, New York 1984; 253–284
  • Blehar M. C., Rosenthal N. E. Seasonal affective disorders and phototherapy. Archives of General Psychiatry 1989; 46: 469–474
  • Brzezinski A., Lynch H. J., Seibel M. M., Deng M. H., Nader T. M., Wurtman R. J. The circadian rhythm of plasma melatonin during the normal menstrual cycle and in amenorrheic women. Journal of Clinical Endocrinology and Metabolism 1988; 66: 891
  • Cardarelli N. F. The role of a thymus-pineal axis in an immune mechanism of aging. Journal of Theoretical Biology 1990; 145: 397–405
  • Cohen H. N., Hay I. D., Annesley T. M., Beastall G. H., Wallace A. M., Spooner R., Thomson J. A., Eastwold P., Klee G. G. Serum immunoreactive melatonin in boys with delayed puberty. Clinical Endocrinology 1981; 17: 517–521
  • Cook S. D., Dowling D. C. A possible association between house pets and multiple sclerosis. Lancet 1977; 1: 980–982
  • Craig J. C., Hawkins S. A., Swallow M. W. Subsets of T lymphocytes in relation to T lymphocyte function in multiple sclerosis. Clinical and Experimental Immunology 1985; 61: 548–555
  • Craig J. C., Haire M., Millar J. H. D., Frazer K. B., Merrett J. D. Immunological control of Epstein-Barr virus-transformed lymphocytes in multiple sclerosis. Clinical Immunology and Immunopathology 1983; 29: 86–93
  • Currie S., Urich H. Concurrence of multiple sclerosis and glioma. Journal of Neurology, Neurosurgery and Psychiatry 1974; 37: 598–605
  • Dalos N. P., Rabins P. V., Brooks B. R., O'Donnell P. Disease activity and emotional state in multiple sclerosis. Annals of Neurology 1983; 13: 573–577
  • Dalton K. The premenstrual syndrome. Charles C. Thomas, Springfield, IL 1964
  • Danforth D., Tamarkin L., Chabner B., Demoss E., Lichter A., Lippman M. Altered diurnal secretory pattern of melatonin in patients with estrogen receptor positive breast cancer. Clinical Research 1982; 30: 532A
  • Daramola G. F., Olowu A. O. Physiological and radiological implications of a low incidence of pineal calcification in nigeria. Neuroendocrinology 1972; 9: 41–57
  • Das Gupta T. K., Terz J. Influence of pineal gland on the growth and spread of melanoma in the hamster. Cancer Research 1967; 27: 1306–1311
  • Dean G. Disseminated sclerosis in South Africa: its relationship to swayback disease and suggested treatment. British Medical Journal 1949; 1: 842–846
  • Dean G. Annual incidence, prevalence and mortality of multiple sclerosis in white South African-born and in white immigrants to South Africa. British Medical Journal 1967; 2: 724–730
  • Dean G., Kurtzke J. F. On the risk of multiple sclerosis according to age at immigration to South Africa. British Medical Journal 1971; 3: 725–729
  • Dean G., McLaughlin H., Brady R. Multiple sclerosis among immigrants to Great Britain. British Medical Journal 1976; 1: 861–864
  • Detels R., Visscher B. R., Haile R. W. Multiple sclerosis and age at migration. American Journal of Epidemiology 1978; 108: 386–393
  • Ebling F. J. P., Foster D. L. Pineal melatonin rhythms and the timing of puberty in mammals. Experientia 1989; 45: 946–954
  • Fischman H. R. Multiple sclerosis: a two stage process. American Journal of Epidemiology 1981; 114: 244–252
  • Frazer K. B. Multiple sclerosis: a virus disease. Brirish Medical Bulletin 1977; 33: 34–39
  • Garfield D. A. S. Multiple sclerosis and affective disorder: 2 case reports of mania with psychosis. Psychotherapy & Psychosomatics 1985; 44: 25–33
  • Garvey M. J., Wesner R., Godes M. Comparison of seasonal and nonseasonal affective disorder. American Journal of Psychiatry 1988; 145: 100–102
  • Ghezzi A., Caputo D. Pregnancy: a factor influencing the course of multiple sclerosis. European Neurology 1981; 20: 115–117
  • Gupta D. Human development and the pineal gland. The pineal gland during development: from fetus to adult, D. Gupta, R. J. Reiter. Croom Helm, London 1986; 117–133
  • Gupta D., Riedel L., Frick H. J. Circulating melatonin in children in relation to puberty, endocrine disorders, functional tests, and racial origin. Neuroendocrinology Letters 1983; 5: 63–78
  • Hafler D. A., Weiner H. L. MS: a CNS and systemic autoimmune disease. Immunology Today 1989; 10: 104–107
  • Haile R. W., Visscher B. R., Detels R., Valdiviezo N. L., Sever J. L., Madden D. L. Relationship between measles HI titers and an MS susceptibility gene. Journal of Neurology 1981; 224: 235–242
  • Hajdu S. I., Porro R. S., Lieberman P. H., Foote F. W. Degeneration of the pineal gland of patients with cancer. Cancer 1972; 29: 706–709
  • Heldmaier G., Hoffmann K. Melatonin stimulates growth of brown tissue. Nature 1974; 247: 224–225
  • Hopper C. L., Matthews C. G., Cleeland C. S. Symptom instability and thermoregulation in multiple sclerosis. Neurology 1972; 22: 142–148
  • Hughes R. A. C. Prospects for the treatment of multiple sclerosis. Journal of the Royal Society of Medicine 1991; 84: 63–65
  • Humbert W., Pevet P. Calcium content and concretions of pineal glands of young and old rats. A scanning and x-ray microanalytical study. Cell and Tissue Research 1991; 263: 593–596
  • Hyyppa M. T., Jolma T., Riekkinen P., Rinne U. K. Effects of L-tryptophan on central indoleamine metabolism and short-lasting neurologic disturbances in multiple sclerosis. Journal of Neural Transmission 1975; 37: 297–304
  • Jankovic B. D. Brown adipose tissue. Its in vivo immunology and involvement in neuroimmunornodulation. Annals of the New York Academy of Sciences 1987; 496: 3–26
  • Jankovic B. D., Isakovic K., Petrovic S. Effect of pinealectomy on immune reactions in the rat. Immunology 1970; 18: 1–5
  • Kawate T., Abo T., Hinum S., Kumagal K. Studies on the bioperiodicity of the immune response. II. co-variations of murine T and B cells and a role of corticosteroids. Journal of Immunology 1981; 126: 1364–1367
  • Kerenyi N. A. Tumors and the pineal gland. Influences of hormones in tumor development, J. A. Kellen, R. Hilf. CRC Press, Boca Raton 1982; 155
  • Kisser W., Harrer G. Amino acid determinations in serum of patients with multiple sclerosis. Wiener Klinische Wochenschrift 1974; 86: 80–82
  • Kitay J. I. Pineal lesions and precocious puberty: a review. Journal of Clinical Endocrinology and Metabolism 1954; 14: 622–625
  • Korn-Lubetzki I., Kahana E., Cooper G., Abramsky O. Activity of multiple sclerosis during pregnancy and puerperium. Annals of Neurology 1984; 16: 229–231
  • Kronfol Z., House J. D. Depression, cortisol and immune function. Lancet 1984; 1: 1026–1027
  • Kurland L. I., Reed D. Geographic and climatic aspects of multiple sclerosis: a review of current hypotheses. American Journal of Public Health 1964; 54: 588–597
  • Kurtzke J. F. On the time of onset in multiple sclerosis. Acta Neurologica Scandinavica 1965; 44: 140–158
  • Kurtzke J. F. Geography in multiple sclerosis. Journal of Neurology 1977; 215: 27–55
  • Kurtzke J. F., Kurland L. T., Goldberg I. D. Multiple sclerosis. Epidemiology of neurologic and sense organ disorders, L. T. Kurland, J. F. F. J. Kurtzke, I. D. Goldberg. Harvard University Press, Cambridge, MA 1973
  • Kurtzke J. F., Hyllested K. Multiple sclerosis in the Faroe Islands: I. clinical and epidemiological features. Annals of Neurology 1979; 5: 6–21
  • Laborde J. M., Dando W. A., Teetzen M. L. Climate, diffuse solar radiation and multiple sclerosis. Society of Science and Medicine 1988; 27: 231–238
  • Lang U., Theintz G., Sizonenko P. C. Plasma cortisol and urinary melatonin in obese patients after a single oral dose of dexamathesone. Pediatric Research 1984; 18: 1214
  • Lang U., Aubert M. L., Conne B. S., Bradtke J. C., Sizonenko P. C. Influence of exogenous melatonin on melatonin secretion and the neuroendocrine reproductive axis of intact male rats during sexual maturation. Endocrinology 1983; 112: 1578–1584
  • Lapin V., Ebels I. The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth. Journal of Neural Transmission 1981; 50: 275–282
  • Leibowitz U., Alter M. Multiple sclerosis: clues to its cause. North-Holland Publishing Co, Amsterdam 1973
  • Leone A. M., Silman R. E., Hill B. T., Whelan R. D. H., Shellard S. A. Growth inhibitory effects of melatonin and its metabolites against ovarian tumor cell lines in vitro. The pineal gland and cancer, D. Gupta, A. Attanasio, R. J. Reiter. Brain Research Promotion, London 1988
  • Levitt A. J., Brown G. M., Kennedy S. H., Stern K. Tryptophan treatment and melatonin response in a patient with seasonal affective disorder. Journal of Clinical psychopharmacology 1991; 11: 74–75
  • Lewy A, Sack K. Biological rhythms and behavior in humans: the effects of light. Hormones and behavior, L. Dennerstein, I. Frazer. Elsevier, Amsterdam 1986
  • Lewy A. J., Wehr T. A., Gold P. W., Goodwin F. K. Plasma melatonin in manic-depressive illness. Catecholamines: basic and clinical frontiers, E. Usdin, I. J. Kopin, J. Barchas. Pergamon Press, Elmsford, NY 1979; 1173–1175
  • Lissoni P., Mauri R., Resentini M., Morabito F., Djemal S., Fraschini F. Melatonin rhythm in some idiopathic hypothalamic-hypophyseal diseases. The pineal gland: endocrine aspects, G. M. Brown, S. D. Wainwright. Pergamon Press, Oxford 1985; 307–312
  • Lynch P. G. Multiple sclerosis and malignant gliomas. British Medical Journal 1974; 3: 577
  • Maestroni G. J. M., Conti A., Pierpaoli W. The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Annals of the New York Academy of Science 1987a; 496: 67–77
  • Maestroni G. J. M., Conti A., Pierpaoli W. Melatonin counteracts the effect of acute stress on the immune system via an opiatergic system. Fundamentals rind clinics in pined research, G. P. Trentini, C. De Gaetani, P. Pevet. Raven Press, New York 1987b; Vol. 44: 277–279
  • Maestroni G. J. M., Conti A., Pierpaoli W. Role of the pineal gland in immunity. III: Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 1988; 63: 465–469
  • Marburg O. Zur Kenntnis der normalen und pathologischen Histologie der Zirbeldruse. Arbeit der Neurologische Institut Wien 1909; 12.: 217–279
  • McCall M., Sutherland J., Acheson E. The frequency of multiple sclerosis in Western Australia. Acta Neurologica Scandinavica 1969; 45: 151–165
  • McGrath R. E., Buckwald B., Resnick E. V. The effect of L-tryptophan on seasonal affective disorder. Journal of Clinical Psychiatry 1990; 51: 161–163
  • Miles A., Philbrick D. R. S. Melatonin and psychiatry. Biological Psychiatry 1988; 23: 405–425
  • Millar J. H. D. The influence of pregnancy on multiple sclerosis. Proceedings of the Royal Society of Medicine 1961; 54: 47
  • Murphy N. B. Carotid cerebral angiography in Uganda: a review of 100 consecutive cases. East African Medical Journal 1968; 45: 47–60
  • Nair N. P. V., Hariharasubramanian N., Pilapil C., Isaac I., Thavundayil J. X. Plasma melatonin—an index of brain aging in humans. Biological Psychiatry 1986; 21: 141–150
  • Nelson D. A., McDowell F. The effects of induced hyperthermia on patients with multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry 1959; 22: 113–116
  • Nir I., Hirschmann N. Pineal N-acetyltransferase depression in rats exposed to hear. Experientia 1978; 34: 1645–1646
  • Nir I., Hirschmann N., Sulman F. G. Pineal gland changes of rats exposed to heat. Experientia 1972; 15: 701–702
  • Nir I., Hirschmann N., Sulman F. G. The effect of heat on rat pineal hydroxyindole-Omethyl transferase activity. Experientia 1975; 31.: 867–868
  • Odeku E. I., Janota I. Intracranial masses-Ibadan. West African Medical Journal 1968; 16: 31–42
  • Ogle C. Melanotic Sarcoma of the pineal body. British Medical Journal 1898; 2: 1745
  • Operskalski E. A., Visscher B. R., Malmgren R. M., Detels R. A case-control study of multiple sclerosis. Neurology 1989; 39: 825–829
  • O'Reilly M. A. K., O'Reilly P. M. R. Temporal influences on relapses of multiple sclerosis. European Neurology 1991; 31: 391–395
  • Palsson P. A., Pattison I. H., Field E. J. Transmission experiments with multiple sclerosis. Slow, latent and temperate virus infections, D. C. Gajdusek, C. J. Gibbs, M. Alpers. NINDB, Washington 1965; 49–54, Monograph 2 (USPHS publication No. 1378
  • Pang S. F., Tang P. L., Tang G. W. K., Yam W. C. Melatonin and other hormonal changes during pregnancy in humans. Journal of Steroid Biochemistry 1984; 20: 1467
  • Pang S. F., Tang P. L., Tang G. W. K., Yam A. W. C. Melatonin and pregnancy. The pineal gland: endocrine aspects, G. M. Brown, S. D. Wainwright. Pergamon Press, Oxford 1985; 157–162
  • Parry B. L., Berga S. L., Mostofi N., Sependa P. A., Kripke D. F., Gillin J. C. Morning versus evening bright light treatment of late luteal phase dysphoric disorder. American Journal of Psychiatry 1989; 146: 1215–1217
  • Parry B. L., Berga S. L., Kripke D. F., Klauber M. R., Laughlin G. A., Yen S. S. C., Gillin J. C. Altered wave form of plasma noturnal melatonin secretion in premenstrual depression. Archives of General Psychiatry 1990; 47: 1139–1146
  • Penny R. Melatonin excretion in normal males and females: increase during pregnancy. Metabolism 1982; 31: 816–822
  • Philo R., Berkowitz A. S. Inhibition of Dunning tumor growth by melatonin. Journal of Urology 1988; 139: 1099–1102
  • Pierpaoli W., Maestroni G. J. M. Neuroimmunomodulation: some recent views and findings. International Journal of Neuroscience 1988; 39: 25–33
  • Pierpaoli W., Yi C. The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone. Journal of Neuroimmunology 1990; 27: 99–109
  • Pirttila T., Antonen J., Syrjala P., Frey H. T-lymphocyte subpopulation levels and immunoglobulin changes in the cerebrospinal fluid of patients with neurologic disorders. Annals of the New York Academy of Sciences 1987; 496: 691–696
  • Poser C. M. Multiple sclerosis. Observations and reflections—a personal memoir. Journal of the Neurological Sciences 1992; 107: 127–140
  • Poskanzer D. C., Schapira K., Miller H. Multiple sclerosis and poliomyelitis. Lancet 1963; 2: 917–921
  • Prineas J. W. The etiology and pathogenesis of multiple sclerosis. Multiple sclerosis and other demyelinating diseases, P. J. Vinken, G. W. Bruyn. North Holland, Amsterdam 1970; 107–160
  • Prineas J. W., Wright R. G. Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Laboratory Investigations 1978; 38: 409–421
  • Quay W. B. Pineal chemistry. Thomas, Springfield 1974; 54–58
  • Reagan T. J., Freiman I. S. Multiple cerebral gliomas in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1973; 36: 523–528
  • Regelson W., Pierpaoli W. Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steriod metabolism, immunologic responses, and chronobiologic factors in tumor growth and therapy. Cancer Investigation 1987; 5: 379–385
  • Reinherz E. L., Weiner H. L., Cohen S. L., Hauser J. A., Distaso J. A., Schlossman S. F. Loss of suppressor T cells in active multiple sclerosis: analysis with monoclonal antibodies. New England Journal of Medicine 1980; 303: 125–129
  • Relkin R., Schneck L. Effects of pinealectomy on rat brain myelin. Proceedings of the Society for Experimental Biology and Medicine 1975; 148: 337–338
  • Relkin R., Fok W. Y., Schneck L. Pinealectomy and brain myelination. Endocrinology 1973; 92: 1426–1428
  • Rella W., Lapin V. Immunocompetence of pinealectomized and simultaneously pinealectomized and thymectomized rats. Oncology 1976; 33: 3–6
  • Rodin A. E. The growth and spread of Walker 256 carcinoma in pinealectomized rats. Cancer Research 1963; 23: 1545–1548
  • Rodin A. E., Overall J. Statistical relationship of weight of the human pineal to age and malignancy. Cancer 1967; 20: 1203–1208
  • Rosen L. N., Livingstone I. R., Rosenthal N. E. Multiple sclerosis and latitude: a new perspective on an old association. Medical Hypotheses 1991; 36: 376–378
  • Rosen L. N., Targum S. D., Terman M., Bryant M. J., Hoffman H., Kasper S. F., Hamovit J. R., Docherty J. P., Welsh B., Rosenthal N. E. Prevalence of seasonal affective disorder at four latitudes. Psychiatry Research 1990; 31: 131–144
  • Sack R. L., Lewy A. J., Erb D. L., Vollmer W. M., Singer C. M. Human melatonin production decreases with age. Journal of Pineal Research 1986; 3: 379–388
  • Sadovnick A. D., Eisen K., Ebers G. C., Paty D. W. Cause of death in patients attending multiple sclerosis clinics. Neurology 1991; 41: 1193–1196
  • Sandyk K., Awerbuch G. I. The pineal gland in multiple sclerosis. International Journal of Neuroscience 1991; 61: 61–67
  • Sandyk K., Awerbuch G. I. Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis. International Journal of Neuroscience, in press
  • Sandyk R., Anastasiadis P. G., Anninos P. A., Tsagas N. The pineal gland and spontaneous abortions: Implications for therapy with melatonin and magnetic fields. International Journal of Neuroscience 1992; 62: 243–250
  • Schapira K., Poskanzer D. C., Newell D. J., Miller H. Marriage, pregnancy and multiple sclerosis. Brain 1966; 89: 419–428
  • Shirodaria P. V., Haire M., Fleming E., Merrett J. D., Hawkins S. A., Roberts S. D. Viral antibody titers: comparison in patients with multiple sclerosis and rheumatoid arthritis. Archives of Neurology 1987; 44: 1237–1241
  • Sibley W. A. Diagnosis and course of multiple sclerosis. Neurobehavioral aspects of multiple sclerosis, S. M. Rao. Oxford University Press, New York 1990; 5–14
  • Sibley W. A., Foley J. M. Seasonal variation in multiple sclerosis and retrobulbar neuritis in northeastern Ohio. Transmission of the American Neurological Association 1965; 90: 295–297
  • Sibley W. A., Paty D. W. A comparison of multiple sclerosis in Arizona (USA) and Ontario (Canada)—preliminary report. Acta Neurologica Scandinavica 1981; 64: 60–65, (suppl 87)
  • Silman R. E., Leone K. M., Hooper R. J. L., Preece M. A. Melatonin, the pineal gland and human puberty. Nature 1979; 282: 301–303
  • Sizonenko P. C., Aubert M. L. Neuroendocrine changes characteristic of sexual maturation. Journal of Natural Transmission 1986; 21: 159–181, (suppl)
  • Skegg D. C. G. Multiple sclerosis: nature or nurture. British Medical Journal 1991; 320: 247–248
  • Skwerer R. G., Jacobson F. M., Ducan C. C., Kelly K. A., Sack D. A., Tamarkin L., Gaist P. A., Kasper S. F., Rosenthal N. E. Neurobiology of seasonal affective disorder and phototherapy. Journal of Biological Rhythms 1988; 3: 135–154
  • Smith J. A., Mee T. J. X., Barnes J. D. Decrease in human serum melatonin concentration with age. Journal of Neural Transmission 1986; 13: 396, (suppl)
  • Starr K. W. Growth and new growth: environmental carcinogens in the process of human ontogeny. Progress in Clinical Cancer 1970; 4: 1–29
  • Swank R. L. A biochemical basis of multiple sclerosis. CC Thomas, Springfield 1961
  • Tagliabue M., Lissoni P., Barni S., Macchi I., Tancini G., Crispino S., Ferri L., Salvini E. A radiologic study by CT scan of pineal size in cancer patients: correlation to melatonin blood levels. Tumor 1989; 75: 226–228
  • Tamarkin L., Danforth D., Lichter A., Demoss E., Cohen M., Chabner B., Lippman M. Decreased nocturnal plasma melatonin peak in patients with estrogen receptor-positive breast cancer. Science 1982; 216: 1003–1005
  • Tang G. W. K., Tang P. L., Yam A. W. C., Pang S. F. Plasma levels of melatonin in pregnant women. Journal of Neural Transmission 1986; 21: 479, (suppl)
  • Tapp E. The human pineal gland in malignancy. Journal of Neural Transmission 1980; 48: 119–124
  • Tapp E. B., Huxley M. The histological appearance of the human pineal gland from puberty to old age. Journal of Pathology 1972; 108: 137–144
  • Taub R. G., Rucker C. W. The relationship of retrobulbar neuritis to multiple sclerosis. American Journal of Opthalmology 1954; 37: 494–497
  • Terman M., Terman J., Quitkin F., Cooper T., Lo E., Gorman J., Stewart J., McGrath P. Response of the melatonin cycle to phototherapy for seasonal affective disorder. Journal of Neursal Transmission 1988; 72: 147–165
  • Thomas D. R., Miles A. Melatonin secretion and age. Biological Psychiatry 1989; 25: 366–367
  • Tillman A. J. B. The effect of pregnancy on multiple sclerosis and its management. Research Publication of the Association for Research in Nervous and Mental Disease 1950; 28: 548–582
  • Toglia J. U. Is migraine due to a deficiency of pineal melatonin. Italian Journal of Neurological sciences 1986; 7: 319–313
  • Trentini G. P., De Gaetani S. F., Criscuolo M., Migaldi M., Ferrari G. Pineal calcification in different physiopathological conditions in humans. Fundamentals and clinics in pined research, G. P. Trentini, C. De Gaetani, P. Pevet. Raven Press, New York 1987; 291–304
  • Visscher B. R., Sullivan C. B., Detels R. Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings. Neurology 1981; 31: 1142–1145
  • Wainerdi H. R. Does the multiple-sclerosis syndrome begin at puberty. Boston Medical Quarterly 1961; 12: 44–17
  • Waldhauser F., Dietzel M. Daily and annual rhythms in human melatonin secretion: role in puberty control. Annals of the New York Academy of Sciences 1985; 435: 205–217
  • Waldhauser F., Steger H. Changes in melatonin secretion with age and pubescence. Journal of Neural Transmission 1986; 21: 183–197, (supp)
  • Waldhauser F., Weiszenbach G., Frisch H., Zeitlhuber U., Waldhauser M., Wurtman R. J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 1984; 1: 362–365
  • Waldhauser F., Weiszenbacher G., Taker E., Gisinger B., Waldhauser M., Schemper M., Frisch H. Alterations in nocturnal serum melatonin levels in humans with growth and aging. Journal of Clinical Endocrinology and Metabolism 1988; 66: 648–652
  • Warren S., Warren K. G. Multiple sclerosis and associated diseases: A relationship to diabetes mellitus. Canadian Journal of Neurological Sciences 1981; 8: 35–39
  • Wehr T. A., Rosenthal N. E. Seasonality and affective illness. American Journal of Psychiatry 1989; 146: 829–839
  • Weiner L. P., Johnson K. T., Herndon R. M. Viral infections and demyelinating diseases. New England Journal of Medicine 1973; 288: 1103–1110
  • Welsh M. G. Pineal calcification: structural and functional aspects. Pineal Research Reviews 1985; 3: 41–68
  • Wetterberg L. Melatonin in humans. physiological and clinical studies. Journal of Neural Transmission 1978; 13: 289–310, (suppl)
  • Whitlock F. A., Siskind M. M. Depression as a major symptom of multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1980; 43: 861–865
  • Winkler P., Helmke K. Age-related incidence of pineal gland calcification in children. Journal of Neural Transmission 1986; 21: 480–481, (suppl)
  • Wuetrich R., Rieder H. P. The seasonal incidence of multiple sclerosis in Switzerland. European Neurology 1970; 3: 257–264
  • Yen S. S. C. Chronic anovulation due to CNS-hypothalamic-pituitary dysfunction. Reproductive endocrinology: physiology, pathophysiology and clinical management, S. S.C. Yen, R. B. Jaffe. W. B. Saunders Company, Philadelphia 1986; 503
  • Young I. M., Francis P. L., Leone A. M., Stovell P., Silma R. E. Constant pineal output and increasing body mass account for declining melatonin levels during human growth and sexual maturation. Journal of Pineal Research 1988; 5: 71–85
  • Zeigler L. H. Multiple sclerosis: a clinical review and follow-up study. Minnesota Medicine 1929; 12: 778–783
  • Zimmerman R. A., Bilaniuk L. T. Age-related incidence of pineal calcification detected by computed tomography. Radiology 1982; 142: 659–662
  • Zimmerman H. M., Netsky M. G. The pathology of multiple sclerosis. Research Publications of the Association for Research in Nervous and Mental Diseases 1950; 28: 271–312

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