22
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Parametric in Vivo Brain Imaging During Activation to Examine Pathological Mechanisms of Functional Failure in Alzheimer Disease

&
Pages 39-56 | Received 26 Oct 1992, Published online: 07 Jul 2009

References

  • Arendt T., Bigl V., Tennstedt A., Arendt A. Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease. Neuroscience 1985; 14: 1–14
  • Ashe J.H., McKenna T.M., Weinberger N.M. Cholinergic modulation of frequency receptive fields in auditory cortex: II. Frequency-specific effects of anticholinesterases provide evidence for a modulatory action of endogenous ACh. Synapse 1989; 4: 44–54
  • Axelrod J., Burch R.M., Jelsema C.L. Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends in Neurosciences 1988; 11: 117–123
  • Bartley S.H. Temporal features of input as crucial factors in vision. Contributions to Sensory Physiology, W.D. Neff. Academic Press, New York 1968; 3: 81–124
  • Blier P., Chaput Y., De Montigny C. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology 1988; 337: 246–254
  • Bushnell M.C., Goldberg M.E., Robinson D.L. Behavioral enhancement of visual responses in monkey cerebral cortex. I. Modulation in posterior parietal cortex related to selective visual attention. Journal of Neurophysiology 1981; 46: 755–772
  • Chandrasekaran K., Stoll J., Brady D.R., Rapoport S.I. Distribution of cytochrome oxidase (COX) activity and mRNA in monkey and human brain. COX mRNA distribution correlates with neurons vulnerable to Alzheimer disease. Society for Neuroscience Abstracts 1992a; 18: 557
  • Chandrasekaran K., Stoll J., Giordano T., Atack J.R., Matocha M.F., Brady D.R., Rapoport S.I. Differential screening of a monkey frontal pole cDNA library: identification and characterization of mRNAs with regional distribution. Journal of Neuroscience Research 1992b; 32: 415–423
  • Chapman R.M., Bragdon H.R. Evoked responses to numerical and non-numerical visual stimuli while problem solving. Nature 1964; 203: 1155–1157
  • Chaput Y., Lesieur P., DeMontigny C. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse 1990; 6: 328–337
  • Chou W.-G., Zain S.B., Rehman S., Tate-Ostroff B., Majocha R.E., Benes F.M., Marotta C.A. Alzheimer cortical neurons containing abundant amyloid mRNA. Relationship to amyloid deposition and senile plaques. Journal of Psychiatric Research 1990; 24: 37–50
  • Corbetta M., Miezin F.M., Dobmeyer S., Shulman G.L., Petersen S.E. Attentional modulation of neural processing of shape, color, and velocity in humans. Science 1990; 248: 1556–1559
  • Curet O., DeMontigny C. Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. II. Receptors mediating the effect of synaptically released norepinephrine. Brain Research 1988; 475: 47–57
  • Davies C.A., Mann D. M. A., Sumpter P.Q., Yates P.O. A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. Journal of the Neurological Science 1987; 78: 151–164
  • DeCarli C., Atack J.R., Ball M.J., Kaye J.A., Grady C.L., Fewster P., Pettigrew K.D., Rapoport S.I., Schapiro M.B. Postmortem regional neurofibrillary tangle densities but not senile plaque densities, are related to regional cerebral metabolic rates for glucose during life in Alzheimer's disease patients. Neurodegeneration 1992; 1: 113–121
  • DeKosky S.T., Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive seventy. Annals of Neurology 1990; 27: 457–464
  • Delacourte A., Bueé L. Maladie d'Alzheimer: la réaction gliale est générale et intense dans tous les territoires du systéme nerveux central. Comptes Rendus de l'Academie des Sciences III 1989; 308: 359–65
  • Desimone R., Ungerleider L.G. Neural mechanisms of visual processing in monkeys. Handbook of neuropsychology, H. Goodglass, A.R. Damasio. Elsevier, Amsterdam 1989; 2: 267–300
  • Duara R., Grady C., Haxby J., Sundaram M., Cutler N.R., Heston L., Moore A., Schlageter N., Larson S., Rapoport S.I. Positron emission tomography in Alzheimer's disease. Neurology 1986; 36: 879–887
  • Duara R., Loewenstein D.A., Barker W.W. Utilization of behavioral activation paradigms for positron emission tomography studies in normal young and elderly subjects and in dementia. Positron emission tomography in dementia, Frontiers of clinical neuroscience, R. Duara. Wiley-Liss, New York 1990; 10: 131–148
  • Duara R., Barker W., Pascal S., Loewenstein D., Boothe T. Behavioral activation PET studies in normal aging and Alzheimer's disease (AD). Journal of Nuclear Medicine 1990; 31: 730
  • Finkel L.H., Reeke G.N., Jr., Edelman G.M. A population approach to the neural basis of perceptual categorization. Neural connections, mental computation, L. Nadel, L.A. Cooper, P. Culicover, R.M. Harnish. MIT Press, Cambridge 1989; 146–179
  • Fisher S.K., Agrmoff B.W. Receptor activation and inositol lipid hydrolysis in neural tissues. Journal of Neurochemistry 1987; 48: 999–1017
  • Folstein M.F., Folstein S.E., McHugh P.R. Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975; 12: 189–198
  • Fowler C.J., O'Neill C., Garlind A., Cowburn R.F. Alzheimer's disease: is there a problem beyond recognition. Trends in Pharmacological Sciences 1990; 11: 183–184
  • Fox P.T., Raichle M.E. Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography. Journal of Neurophysiology 1984; 51: 1109–1120
  • Fox P.T., Raichle M.E. Stimulus rate determines regional brain blood flow in striate cortex. Annals of Neurology 1985; 17: 303–305
  • Frackowiak R. S. J., Pozzilli C., Legg N.J., DuBoulay G.H., Marshall J., Lenzi G.L., Jones T. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain 1981; 104: 753–778
  • Geaney D.P., Soper N., Shepstone B.J., Cowen P.J. Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease. Lancet 1990; 335: 1484–1487
  • Grady C., Haxby J., Horwitz B., Schapiro M., Carson R., Herscovitch P., Rapoport S. Activation of regional cerebral blood flow (rCBF) in extrastriate cortex during face matching task in patients with dementia of the Alzheimer type (DAT). Society for Neuroscience Abstracts 1990; 16: 149
  • Grady C.L., Haxby J.V., Schlageter N.L., Berg G., Rapoport S.I. Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer type. Neurology 1986; 36: 1390–1392
  • Grady C.L., Haxby J.V., Horwitz B., Sundaram M., Berg G., Schapiro M., Friedland R.P., Rapoport S.I. Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. Journal of Clinical and Experimental Neuropsychology 1988; 10: 576–596
  • Grady C.L., Haxby J.V., Horwitz B., Gillette J., Salerno J.A., Gonzalez-Aviles A., Ungerleider L.G., Carson R.E., Herscovitch P., Schapiro M.B., Mishkin M., Rapoport S.I. Activation of regional cerebral blood flow during a face perception task in patients with dementia of the Alzheimer type. Neurobiology of Aging., in press
  • Greenamyre J.T., Penney J.B., Damato C.J., Young A.B. Dementia of the Alzheimer's type: changes in hippocampal L-[3H] glutamate binding. Journal of Neurochemistry 1987; 48: 543–551
  • Haxby J.V., Duara R., Grady C.L., Cutler N.R., Rapoport S.I. Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism 1985; 5: 193–200
  • Haxby J.V., Grady C.L., Duara R., Schlageter N., Berg G., Rapoport S.I. Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. Archives of Neurology 1986; 43: 882–885
  • Haxby J.V., Grady C.L., Koss E., Horwitz B., Schapiro M., Friedland R.P., Rapoport S.I. Heterogeneous anterior-posterior metabolic patterns in dementia of the Alzheimer type. Neurology 1988; 38: 1853–1863
  • Haxby J.V., Grady C.L., Koss E., Horwitz B., Heston L., Schapiro M., Friedland R.P., Rapoport S.I. Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Archives of Neurology 1990; 47: 753–760
  • Haxby J.V., Grady C.L., Horwitz B., Ungerleider L.G., Mishkin M., Carson R.E., Herscovitch P., Schapiro M.B., Rapoport S.I. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings of the National Academy of Sciences USA 1991; 88: 1621–1625
  • Horwitz B., Grady C.L., Schlageter N.L., Duara R., Rapoport S.I. Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease. Brain Research 1987; 407: 294–306
  • Horwitz B. Simulating functional interactions in the brain: a model for examining correlations between regional cerebral metabolic rates. International Journal of Bio-medical Computing 1990; 26: 149–170
  • Lacopino A.M., Christakos S. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proceedings of the National Academy of Sciences USA 1990; 87: 4078–4082
  • Jasper H.H. The fundamental refractoriness of certain cortical neurons. XIe Congrès. International de Psychologie, Paris 1937; 226–227
  • Kadekaro M., Crane A.M., Sokoloff L. Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. Proceedings of the National Academy of Sciences USA 1985; 82: 6010–6013
  • Kessler J., Herholz K., Grond M., Heiss W.-D. Impaired metabolic activation in Alzheimer's disease: a PET study during continuous visual recognition. Neuropsychologia 1990; 29: 229–243
  • Kessler J., Herholz K., Grond M., Mielke R., Heiss W.-D. Reduced metabolic reserve in Alzheimer's disease assessed by cognitive stimulation and PET. Journal of Cerebral Blood Flow, and Metabolism II 1991; S15, Supplement 2
  • Koo E.H., Sisodia S.S., Archer D.R., Martin L.J., Weidemann A., Beyreuther K., Fischer P., Masters C.L., Price D.L. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proceedings of the National Academy of Sciences USA 1990; 87: 1561–1565
  • Korn H., Triller A., Mallet A., Faber D.S. Fluctuating responses at a central synapses: n of binomial fit predicts number of stained presynaptic boutons. Science (N.Y.) 1981; 213: 898–901
  • Kumar A., Schapiro M.B., Grady C., Haxby J.V., Wagner E., Salerno J.A., Friedland R.P., Rapoport S.I. High-resolution PET studies in Alzheimer's disease. Neuropsychophar-macology 1991; 4: 35–46
  • Lehninger A.L., Hossman K.-A. Biochemistry, 2nd Edition. Worth Publishers., New York 1975; 1–1104
  • Leniger-Follert E. Microflow and evoked potentials in the somatomotor cortex of the cat brain during specific sensory activation. Acta Neurologica Scandinavica, Supplement 1979; 72: 60, 10–11
  • Lewis D.A., Campbell M.J., Terry R.D., Morrison J.H. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. Journal of Neuroscience 1987; 7: 1799–1808
  • Livingstone M., Hubel D. Segregation of form, color, movement, and depth: anatomy, physiology, and perception. Science 1988; 240: 740–749
  • Lou H.C., Edvinsson L. Innervation of the cerebral vasculature and its putative role in the coupling of flow to metabolism. Regulatory mechanisms of neuron to vessel communication in the brain. NATO AS1 Series, Series H, Cell Biology, F. Battaini, S. Govoni, M. S. Magnoni, M. Trabucchi. Springer Verlag, Berlin 1989; 33: 75–95
  • Luxenberg J.S., Haxby J.V., Creasey H., Sundaram M., Rapoport S.I. Rate of ventricular enlargement in dementia of the Alzheimer type correlates with rate of neuropsychological deterioration. Neurology 1987; 37: 1135–1140
  • Mann D. M. A., Marcyniuk B., Yates P.O., Neary D., Snowden J.S. The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathology and Applied Neurobiology 1988; 14: 177–195
  • Marsh G.R., Thompson L.W. Psychophysiology of aging. Handbook of the psychology of aging, J. E. Birren, K. W. Schaie. Van Nostrand Reinhold., New York 1977; 219–248
  • Marsh J.T., Schubarth G., Brown W.S., Riege W., Strandburg R., Dorsey D., Maltese A., Kuhl D. PET and P300 relationships in early Alzheimer's disease. Neurobiology of Aging 1990; II: 471–476
  • Masliah E., Terry R.D., Alford M., De Teresa R., Hansen L.A. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. American Journal of Pathology 1991; 138: 235–246
  • Masliah E., Mallory M., Hansen L., Alford M., Albright T., DeTeresa R., Terry R., Baudier J., Saitoh T. Patterns of aberrant sprouting in Alzheimer's disease. Neuron 1991; 6: 729–739
  • McKenna T.M., Ashe J.H., Weinberger N.M. Cholinergic modulation of frequency receptive fields in auditory cortex: I. Frequency-specific effects of muscarinic agonists. Synapse 1989; 4: 30–43
  • Mesulam M.M. A cortical network for directed attention and unilateral neglect. Annals of Neurology 1981; 10: 309–325
  • Morrison J.H., Hof P.R., Campbell M.J., DeLima A.D., Voigt T., Bouras C., Cox K., Young W.G. Cellular pathology in Alzheimer's disease: implications for corticocortical disconnection and differential vulnerability. Imaging, cerebral topography and Alzheimer's disease. Research and perspectives in Alzheimer's disease, S. I. Rapoport, H. Petit, D. Leys, Y. Christen. Springer-Verlag., Fondation Ipsen, Berlin 1990; 19–40
  • Mubrin Z., Knezevic S., Spilich G., Risberg J., Gubarev N., Wannenmacher W., Vucinic G. Normalization of rCBF pattern in senile demenia of the Alzheimer's type. Psychiatry Research 1989; 29: 303–306
  • Muller-Preuss P., Mitzdorf U. Functional anatomy of the inferior colliculus and the auditory cortex: current source density analyses of click-evoked potentials. Hearing Research 1984; 16: 133–142
  • Nariai T., DeGeorge J.J., Lamour Y., Rapoport S.I. In vivo brain incorporation of [1-14C] arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of the nucleus basalis magnocellularis. Brain Research 1991; 559: 1–9
  • Ohm T.G., Bohl J., Lemmer B. Reduced CAMP-signal transduction in postmortem hippocampus of demented old people. Progress in Clinical and Biological Research 1989; 317: 501–509
  • Pardo J.V., Fox P.T., Raichle M.E. Localization of a human system for sustained attention by positron emission tomography. Nature 1991; 349: 61–64
  • Pellmar T. Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro. Brain Research 1986; 364: 377–381
  • Pellmar T.C., Schauer D.A., Zeman G.H. Time-and dose-dependent changes in neuronal activity produced by X radiation in brain slices. Radiation Research 1990; 122: 209–214
  • Perry N.W., Childers D.G. The human visual evoked response; method and theory. Charles C. Thomas., Springfield 1969
  • Pettegrew J.W., Panchalingam K., Moossy J., Martinez J., Rao G., Boller F. Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease. Archives of Neurology 1988; 45: 1093–1996
  • Phelps M.E., Mazziotta J.C., Kuhl D.E., Nuwer M., Packwood J., Metter J., Engel J., Jr. Tomographic mapping of human cerebral metabolism: visual stimulation and deprivation. Neurology 1981; 31: 517–529
  • Rapoport S.I. Brain evolution and Alzheimer's disease. Revue Neurologique (Paris) 1988; 144: 79–90
  • Rapoport S.I. Topography of Alzheimer's disease: involvement of association neocortices and connected regions; pathological, metabolic and cognitive correlations; relation to evolution. Imaging, cerebral topography and Alzheimer's disease. Research and perspectives in Alzheimer's disease, S.I. Rapoport, H. Petit, D. Leys, Y. Christen. Springer Verlag., Fondation Ipsen, Berlin 1990; 1–17
  • Rapoport S.I. Integrated phylogeny of the primate brain, with special reference to humans and their diseases. Brain Research Reviews 1990; 15: 267–294
  • Rapoport S.I., Horwitz B., Grady C.L. Hypothesis: resting and activated PET scans of Alzheimer patients suggest reversible failure of synaptic transmission. Journal of Cerebral Blood Flow and Metabolism II (Supplement 2) 1991; S170
  • Rapoport S.I. Positron emission tomography in Alzheimer's disease in relation to disease pathogenesis: a critical review. Cerebrovascular Brain Metabolism Reviews 1991; 3: 297–335
  • Regan D. Evoked potentials in psychology, sensory physiology, and clinical medicine. Chapman & Hall., London 1972; 1–328
  • Reivich M. Blood flow metabolism couple in brain. Research Publications. Association for Research in Nervous and Mental Disease 1974; 53: 125–40
  • Roland P.E. Cortical regulation of selective attention in man. A regional cerebral blood flow study. Journal of Neurophysiology 1982; 48: 1059–1078
  • Roy C.S., Sherrington C.S. On the regulation of the blood supply to the brain. Journal of Physiology (London) 1890; 11: 85–108
  • Rumelhart D.E., Hinton G.E., McClelland J.L. A general framework for parallel distributed processing. Parallel distributed processing. Explorations in the microstructure of cognition. Foundations, D. E. Rumelhart, J. L. McClelland. MIT Press, Cambridge 1987; 1: 45–76, PDP Research Group
  • Scheff S.W., DeKosky S.T., Price D.A. Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiology of Aging 1990; 11: 29–37
  • Schwartz R.S., Burka C., Snars J., Gordon E., Batchelor J., Kostalas G., Meares R., Yiannikas C. Regional cerebral blood flow and recognition memory in elderly normals: potential application to Alzheimer's disease. Clinical and Experimental Neurology 1991; 28: 56–65
  • Shagass C. Evoked brain potentials in psychiatry. Plenum Press., New York 1972; 1–274
  • Shimohama S., Ninomiya H., Saitoh T., Terry R.D., Fukunaga R., Taniguchi T., Fujiwara M., Kimura J., Kameyama M. Changes in signal transduction in Alzheimer's disease. Journal of Neural Transmission Supplement 1990; 30: 69–78
  • Siesjö B.K. Brain energy metabolism. John Wiley & Sons., Chichester 1978; 1–607
  • Sokoloff L. The action of drugs on the cerebral circulation. Pharmacological Reviews 1959; 11: 1–85
  • Sokoloff L. Metabolism of ketone bodies by the brain. Annual Reviews of Medicine 1973; 24: 271–280
  • Sokoloff L. Relationship between functional activity and energy metabolism in the nervous system: whether, where and why. Brain work and mental activity. Quantitative studies with radioactive tracers, N.A. Lassen, D.H. Ingvar, M.E. Raichle, L. Friberg. Alfred Benzon Symposium, Munksgaard, Copenhagen 1991; 31: 52–67
  • Spitzer H., Desimone R., Moran J. Increased attention enhances both behavioral and neuronal performance. Science 1988; 240: 338–340
  • Subbarao K. V., Richardson J.S., Ang L.C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. Journal of Neurochemistry 1990; 55: 342–345
  • Tam S.W., Rominger D., Nickolson V.J. Novel receptor site involved in enhancement of stimulus-induced acetylcholine, dopamine, and serotonin release. Molecular Pharmacology 1991; 40: 16–21
  • Terry R.D., Peck A., DeTeresa R., Schechter R., Horoupian D.S. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Annals of Neurology 1981; 10: 184–192
  • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annals of Neurology 1991; 30: 572–580
  • Tolliver J.M., Pellmar T.C. Ionizing radiation alters neuronal excitability in hippocampal slices of the guinea pig. Radiation Research 1987; 112: 555–563
  • Watson M., Roeske W.R., Yamamura H.I. Cholinergic receptor heterogeneity. Psychopharmacology: the third generation of progress, Chapter 24, H.Y. Meltzer. Raven Press., New York 1987; 241–248
  • Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982; 215: 1237–1239
  • Whitehouse P.J. Neurotransmitter receptor alterations in Alzheimer disease: a review. Alzheimer Disease and Associated Disorders 1987; 1: 9–18
  • Wilson K., Bowen D., Francis P., Tyrrell P. Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease. British Journal of Psychiatry 1991; 158: 558–562
  • Yarowsky P.J., Ingvar D.H. Neuronal activity and energy metabolism. Federation Proceedings 1981; 40: 2353–2362
  • Yates C.M., Simpson J., Gordon A., Maloney A. F. J., Allison Y., Ritchie I.M., Urquhart A. Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Research 1983; 280: 119–126

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.