The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F

References

• Behl C., Davis J., Cole G. M., Schubert D. Vitamin E protects nerve cells from amyloid P protein toxicity. Biochemical and Biophysical Research Communications 1992; 186: 944–950
   PubMed Web of Science ®Google Scholar
• Dyrks T., Dyrks E., Masters C. L., Beyreuther K. Amyloidogenicity of rodent and human P-A4 sequences. FEBS Letrer 1993; 324: 231–236
   PubMed Web of Science ®Google Scholar
• Glenner G. G., Wong C. W. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochemical and Biophysical Research Communications 1984; 120: 885–890
   PubMed Web of Science ®Google Scholar
• Kawarabayashi T., Shoji M., Harigaya Y., Yamaguchi H., Hirai S. Expression of APP in the early stage of brain damage. Brain Research 1991; 563: 334–338
   PubMed Web of Science ®Google Scholar
• Koh J., Yang L. L., Cotman C. W. β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Research 1990; 533: 315–320
   PubMed Web of Science ®Google Scholar
• Loo D. T., Copani A., Pike C. J., Whittemore E. R., Walencewicz A. J., Cotman C. W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proceedings of the National Academy of Sciences, USA 1993; 90: 7951–7955
   PubMed Web of Science ®Google Scholar
• Masters C. L., Multhaup G., Simms G., Pottgiesser J., Martins R. N., Beyreuther K. Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO Journal 1985; 4: 2757–2763
   PubMed Web of Science ®Google Scholar
• Mattson M. P., Cheng B., Davis D., Bryant K., Lieberberg I., Rydel R. E. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. Journal of Neuroscience 1992; 12: 376–389
   PubMed Web of Science ®Google Scholar
• Monyer H., Hartley D. M., Choi D. W. 21 -Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures. Neuron 1990; 5: 121–126
   PubMed Web of Science ®Google Scholar
• Pike C. J., Burdick D., Walencewicz A. J., Glabe C. G., Cotman C. W. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state. Journal of Neuroscience 1993; 13: 1676–1687
   PubMed Web of Science ®Google Scholar
• Pike C. J., Cummings B. J., Cotman C. W. β-amyloid induces neuritic dystrophy in vitro: Similarities with Alzheimer pathology. NeuroReport 1992; 3: 769–772
   PubMed Web of Science ®Google Scholar
• Pike C. J., Walencewicz A. J., Glabe C. G., Cotman C. W. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Research 1991; 563: 311–314
   PubMed Web of Science ®Google Scholar
• Richardson J. S. Free radicals in the genesis of Alzheimer's disease. Annals of the New York Academy of Science 1993; 695: 73–76
   PubMed Web of Science ®Google Scholar
• Saunders R. D., Luttman C. A., Keith P. T., Little S. P. P-amyloid protein potentiates H2O2-induced neuron degeneration in vitro. Society for Neuroscience Abstracts 1991; 17: 1447
   Google Scholar
• Schubert D., Kimura H., Maher P. Growth factors and vitamin E modify neuronal glutamate toxicity. Proceedings of the National Academy Sciences, U. S. A. 1992; 89: 8264–8267
   PubMed Web of Science ®Google Scholar
• Selkoe D. Biochemistry of altered brain proteins in Alzheimer's disease. Annual Reviews of Neuroscience 1989; 12: 463–490
   PubMed Web of Science ®Google Scholar
• Subbarao K. V., Richardson J. S., Ang L. C. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. Journal of Neurochemistry 1990; 55: 342–345
   PubMed Web of Science ®Google Scholar
• Takadera T., Sakura N., Mohri T., Hashimoto T. Toxic effect of a β-amyloid peptide (p22–35) on the hippocampal neuron and its prevention. Neuroscience Letters 1993; 161: 41–44
   PubMed Web of Science ®Google Scholar
• Whitson J. S., Glabe C. G., Shintani E., Abear A, Cotman C. W. P-amyloid protein promotes neuritic branching in hippocampal cultures. Neuroscience Letters 1990; 110: 319–324
   PubMed Web of Science ®Google Scholar
• Whitson J. S., Selkoe D. J., Cotman C. W. Amyloid p protein enhances the survival of hippocampal neurons in vitro. Science 1989; 243: 1488–1490
   PubMed Web of Science ®Google Scholar
• Yankner B. A., Duffy L. K., Kirschner D. A. Neurotrophic and neurotoxic effects of amyloid p protein: Reversal by tachykinin neuropeptides. Science 1990; 250: 279–282
   PubMed Web of Science ®Google Scholar
• Zhou Y., Richardson J. S., Mombourquette M. J., Weil J. A. Increased free radical formation in autopsy samples of Alzheimer's cortex shown by electron paramagnetic resonance. 1994, Submitted
   Google Scholar