27
Views
1
CrossRef citations to date
0
Altmetric
Anatomical Pathology

Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma

, , , , , & show all
Pages 524-533 | Received 22 Nov 2009, Accepted 29 Mar 2010, Published online: 20 Sep 2010

References

  • Russell WO, Ibanez ML, Clark RL, White EC. Thyroid carcinoma. Classification, intraglandular dissemination, and clinicopathological study based upon whole organ sections of 80 glands. Cancer 1963; 16: 1425–1460.
  • Katoh R, Sasaki J, Kurihara H, et al Multiple thyroid involvement (intraglandular metastasis) in papillary thyroid carcinoma. A clinicopathologic study of 105 consecutive patients. Cancer 1992; 70: 1585–1590.
  • Jovanovic L, Delahunt B, McIver M, Eberhardt NL, SK Grebe. Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone. J Pathol 2008; 215: 145–154.
  • De Lellis RA, Lloyd RA, Heitz PU, Eng C, editors. Pathology and Genetics of Tumours of Endocrine Organs. World Health Organization Classification of Tumours. Lyon: International Agency for Research on Cancer, 2004; 320.
  • Trovisco V, Vieira de Castro I, Soares P, et al BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 2004; 202: 247–251.
  • Wreesmann VB, Ghossein RA, Hazel M, et al Follicular variant of papillary thyroid carcinoma: genome-wide appraisal of a controversial entity. Genes Chromosomes Cancer 2004; 40: 355–364.
  • Sobrinho-Simoes M, Preto A, Rocha AS, et al Molecular pathology of well-differentiated thyroid carcinomas. Virchows Arch 2005; 447: 787–793.
  • Baloch ZW, LiVolsi VA. Etiology and significance of the optically clear nucleus. Endocr Pathol 2002; 13: 289–299.
  • Prendiville S, Burman KD, Ringel MD, et al Tall cell variant: an aggressive form of papillary thyroid carcinoma. Otolaryngol Head Neck Surg 2000; 122: 352–357.
  • Salajegheh A, Petcu EB, Smith RA, Lam AK. Follicular variant of papillary thyroid carcinoma: a diagnostic challenge for clinicians and pathologists. Postgrad Med J 2008; 84: 78–82.
  • Dietmaier W, Hartmann A, Wallinger S, et al Multiple mutation analyses in single tumor cells with improved whole genome amplification. Am J Pathol 1999; 154: 83–95.
  • Vogelstein B, Fearon ER, Kern SE, et al Allelotype of colorectal carcinomas. Science 1989; 244: 207–211.
  • Herrmann MA, Hay ID, Bartelt DJ, et al Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. J Clin Invest 1991; 88: 1596–1604.
  • Califano JA, Johns MM 3rd, Westra WH, et al An allelotype of papillary thyroid cancer. Int Cancer 1996; 69: 442–444.
  • Ward LS, Brenta G, Medvedovic M, Fagin JA. Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas. J Clinl Endocrinol Metabol 1998; 83: 525–530.
  • Kitamura Y, Shimizu K, Tanaka S, Ito K, Emi M. Association of allelic loss on 1q, 4p, 7q, 9p, 9q, and 16q with postoperative death in papillary thyroid carcinoma. Clin Cancer Res 2000; 6: 1819–1825.
  • Girard L, Zöchbauer-Müller S, Virmani AK, Gazdar AF, Minna JD. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 2000; 60: 4894–4906.
  • Soares P, dos Santos NR, Seruca R, Lothe RA, Sobrinho-Simöes M. Benign and malignant thyroid lesions show instability at microsatellite loci. Eur J Cancer 1997; 33: 293–296.
  • Lazzereschi D, Palmirotta R, Ranieri A, et al Microsatellite instability in thyroid tumours and tumour-like lesions. Br J Cancer 1999; 79: 340–345.
  • Rodrigues-Serpa A, Catarino A, Soares J. Loss of heterozygosity in follicular and papillary thyroid carcinomas. Cancer Genetics Cytogenetics 2003; 141: 26–31.
  • Zou M, Shi Y, Farid NR, al-Sediary ST, Paterson MC. FHIT gene abnormalities in both benign and malignant thyroid tumours. Eur J Cancer 1999; 35: 467–472.
  • McCarthy RP, Wang M, Jones TD, Strate RW, Cheng L. Molecular evidence for the same clonal origin of multifocal papillary thyroid carcinomas. Clin Cancer Res 2006; 12: 2414–2418.
  • Chatterjee A, Pulido HA, Koul S, et al Mapping the sites of putative tumor suppressor genes at 6p25 and 6p21.3 in cervical carcinoma: occurrence of allelic deletions in precancerous lesions. Cancer Res 2001; 61: 2119–2123.
  • Kawana Y, Ichikawa T, Suzuki H, et al Loss of heterozygosity at 7q31.1 and 12p13-12 in advanced prostate cancer. Prostate 2002; 53: 60–64.
  • Beder LB, Gunduz M, Ouchida M, et al Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas. Lab Invest 2003; 83: 99–105.
  • Narayan G, Pulido HA, Koul S, Lu XY, et al Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progression. Oncogene 2003; 22: 3489–3499.
  • Stoehr R, Wissmann C, Suzuki H, et al Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer. Lab Invest 2004; 84: 465–478.
  • Wan J, Li H, Li Y, Zhu ML, Zhao P. Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients. World J Gastroenterol 2006; 12: 1033–1037.
  • Zedenius J, Vallin G, Svensson A, et al Allelotyping of follicular thyroid tumors. Hum Genetics 1995; 96: 27–32.
  • Segev DL, Saji M, Phillips GS, et al Polymerase chain reaction-based microsatellite polymorphism analysis of follicular and Hurthle cell neoplasms of the thyroid. J Clin Endocrinol Metab 1998; 83: 2036–2042.
  • Wreesmann VB, Sieczka EM, Socci ND, et al Genome-wide profiling of papillary thyroid cancer identifies MUCI as an independent prognostic marker. Cancer Res 2004; 64: 3780–3789.
  • Padalecki SS, Troyer DA, Hansen MF, et al Identification of two distinct regions of allelic imbalance on chromosome 18q in metastatic prostate cancer. Int Cancer 2000; 85: 654–658.
  • Yashiro M, Carethers JM, Laghi L, et al Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res 2001; 61: 2676–2683.
  • Powell CA, Bueno R, Borczuk AC, et al Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers. Lung Cancer 2003; 39: 23–29.
  • Sunamura M, Lefter LP, Duda DG, et al The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. Pancreas 2004; 28: 311–316.
  • Takebayashi S, Hickson A, Ogawa T, et al Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer. Genes Chromosomes Cancer 2004; 41: 145–154.
  • Lin X, Finkelstein S, Zhu B, Silverman J. Molecular analysis of multifocal papillary thyroid carcinoma. J Mol Endocrinol 2008; 41: 195–203.
  • Machens A, Holzhausen HJ, Lautenschläger C, Dralle H. The tall-cell variant of papillary thyroid carcinoma: a multivariate analysis of clinical risk factors. Arch Surg 2004; 389: 278–282.
  • Grebe SK, McIver B, Hay ID, et al Frequent loss of heterozygosity on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma. J Clin Endocrinol Metab 1997; 82: 3684–3691.
  • Kitamura Y, K Shimizu, Tanaka S, Ito K, Emi M. Allelotyping of anaplastic thyroid carcinoma: frequent allelic losses on 1q, 9p, 11, 17, 19p, and 22q, Genes. Chromosomes Cancer 2000; 27: 244–251.
  • Kitamura Y, Shimizu K, Tanaka S, Ito K, Emi M. Allelotyping of follicular thyroid carcinoma: frequent allelic losses in chromosome arms 7q, 11p, and 22q. J Clin Endocrinol Metab 2001; 86: 4268–4272.
  • Rodrigues RF, Roque L, Rosa-Santos J, Cid O, Soares J. Karyotypic characterization of papillary thyroid carcinomas. Cancer 2001; 92: 2529–2538.
  • Rodrigues RF, Roque L, Rosa-Santos J, Cid O, Soares J. Chromosomal imbalances associated with anaplastic transformation of follicular thyroid carcinomas. Br J Cancer 2004; 90: 492–496.
  • Giannini R, Ugolini C, Lupi C, et al The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma. J Clin Endocrinol Metab 2007; 92: 3511–3516.
  • Hittelman WN. Genetic instability in epithelial tissues at risk for cancer. Ann Sci 2001; 952: 1–12.
  • Tabor MP, Brakenhoff RH, vanHouten VM, et al Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin Cancer Res 2001; 7: 1523–1532.
  • Fukino K, Shen L, Matsumoto S, et al Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets. Cancer Res 2004; 64: 7231–7236.
  • Braakhuis BJ, Leemans CR, Brakenhoff RH. Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice. J Pathol 2004; 203: 620–621.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.