Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers

References

• Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059–3087.
   PubMed Web of Science ®Google Scholar
• Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res 2007; 67: 3583–3593.
   PubMed Web of Science ®Google Scholar
• Cutcliffe C, Kersey D, Huang CC, Zeng Y, Walterhouse D, Perlman EJ. Clear cell sarcoma of the kidney: up-regulation of neural markers with activation of the sonic hedgehog and Akt pathways. Clin Cancer Res 2005; 11: 7986–7994.
   Google Scholar
• Berman DM, Karhadkar SS, Hallahan AR, et al Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002; 297: 1559–1561.
   PubMed Web of Science ®Google Scholar
• Karhadkar SS, Bova GS, Abdallah N, et al Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004; 431: 707–712.
   PubMed Web of Science ®Google Scholar
• Liao X, Siu MK, Au CW, et al Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009; 30: 131–140.
   PubMed Web of Science ®Google Scholar
• Bailey JM, Swanson BJ, Hamada T, et al Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 2008; 14: 5995–6004.
   PubMed Web of Science ®Google Scholar
• Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003; 422: 313–317.
   PubMed Web of Science ®Google Scholar
• Stecca B, Ruiz I Altaba A. The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. J Biol 2002; 1: 9.
   Google Scholar
• Adolphe C, Narang M, Ellis T, Wicking C, Kaur P, Wainwright B. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 2004; 131: 5009–5019.
   PubMedGoogle Scholar
• van den Brink GR, Bleuming SA, Hardwick JC, et al Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004; 36: 277–282.
   PubMed Web of Science ®Google Scholar
• Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000; 127: 2763–2772.
   PubMed Web of Science ®Google Scholar
• Chatel G, Ganeff C, Boussif N, et al Hedgehog signaling pathway is inactive in colorectal cancer cell lines. Int J Cancer 2007; 121: 2622–2627.
   PubMed Web of Science ®Google Scholar
• Hynes M, Stone DM, Dowd M, et al Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 1997; 19: 15–26.
   PubMedGoogle Scholar
• Lee J, Platt KA, Censullo P, Ruiz I, Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997; 124: 2537–2552.
   PubMed Web of Science ®Google Scholar
• Marigo V, Tabin CJ. Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci USA 1996; 93: 9346–9351.
   PubMed Web of Science ®Google Scholar
• Evangelista M, Tian H, de Sauvage FJ. The hedgehog signaling pathway in cancer. Clin Cancer Res 2006; 12: 5924–5928.
   PubMed Web of Science ®Google Scholar
• Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006; 5: 1026–1033.
   PubMed Web of Science ®Google Scholar
• Huang S, He J, Zhang X, et al Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006; 27: 1334–1340.
   PubMed Web of Science ®Google Scholar
• Feldmann G, Dhara S, Fendrich V, et al Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007; 67: 2187–2196.
   PubMed Web of Science ®Google Scholar
• Berman DM, Karhadkar SS, Maitra A, et al Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846–851.
   PubMed Web of Science ®Google Scholar
• Yoo YA, Kang MH, Kim JS, Oh SC. Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. Carcinogenesis 2008; 29: 480–490.
   PubMed Web of Science ®Google Scholar
• Douard R, Moutereau S, Pernet P, et al Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Surgery 2006; 139: 665–670.
   PubMed Web of Science ®Google Scholar
• Monzo M, Moreno I, Artells R, et al Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. Cancer Lett 2006; 233: 117–123.
   PubMed Web of Science ®Google Scholar
• Qualtrough D, Buda A, Gaffield W, Williams AC, Paraskeva C. Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer 2004; 110: 831–837.
   PubMed Web of Science ®Google Scholar
• Akiyoshi T, Nakamura M, Koga K, et al Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. Gut 2006; 55: 991–999.
   PubMedGoogle Scholar
• Wang LH, Choi YL, Hua XY, et al Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod Pathol 2006; 19: 675–683.
   PubMed Web of Science ®Google Scholar
• Chen X, Horiuchi A, Kikuchi N, et al Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: its inhibition leads to growth suppression and apoptosis. Cancer Sci 2007; 98: 68–76.
   PubMed Web of Science ®Google Scholar
• Baisse B, Bian YS, Benhattar J Microdissection by exclusion and DNA extraction for multiple PCR analyses from archival tissue sections. Biotechniques 2000; 28: 856–858, 860, 862.
   Google Scholar
• Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821–9826.
   PubMed Web of Science ®Google Scholar
• Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432: 324–331.
   PubMed Web of Science ®Google Scholar
• He J, Sheng T, Stelter AA. et al Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. J Biol Chem 2006; 281: 35598–35602.
   Google Scholar
• Watt FM. Unexpected Hedgehog-Wnt interactions in epithelial differentiation. Trends Mol Med 2004; 10: 577–580.
   Google Scholar
• Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ. Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 2004; 203: 909–917.
   PubMed Web of Science ®Google Scholar
• Van Den Brink GR, Peppelenbosch MP. Expression of hedgehog pathway components in the adult colon. Gastroenterology 2006; 130: 619.
   Google Scholar
• Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000; 103: 311–320.
   PubMed Web of Science ®Google Scholar
• Pathi S, Pagan-Westphal S, Baker DP, et al Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 2001; 106: 107–117.
   PubMed Web of Science ®Google Scholar
• Hammerschmidt M, Brook A, McMahon AP. The world according to hedgehog. Trends Genet 1997; 13: 14–21.
   PubMed Web of Science ®Google Scholar