The antimicrobial peptide LL37 and its truncated derivatives potentiates proinflammatory cytokine induction by lipoteichoic acid in whole blood

References

• Daneshian M, Wendel A, Hartung T, von Aulock S. High sensitivity pyrogen testing in water and dialysis solutions. J Immunol Methods 2008;336:64–70.
   PubMed Web of Science ®Google Scholar
• Kinsner A, Boveri M, Hareng L, Brown GC, Coecke S, Hartung T, Bal-Price A. Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide. J Neurochem 2006;99:596–607.
   PubMed Web of Science ®Google Scholar
• Wanecek M, Weitzberg E, Rudehill A, Oldner A. The endothelin system in septic and endotoxin shock. Eur J Pharmacol 2000;407:1–15.
   PubMed Web of Science ®Google Scholar
• Gura T. Innate immunity. Ancient system gets new respect. Science 2001;291:2068–71.
   PubMed Web of Science ®Google Scholar
• Hancock RE. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 2001;1:156–64.
   PubMedGoogle Scholar
• Scott MG, Gold MR, Hancock RE. Interaction of cationic peptides with lipoteichoic acid and gram-positive bacteria. Infect Immun 1999;67:6445–53.
   PubMed Web of Science ®Google Scholar
• Scott MG, Davidson DJ, Gold MR, Bowdish D, Hancock RE. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 2002;169:3883–91.
   PubMed Web of Science ®Google Scholar
• Kandler K, Shaykhiev R, Kleemann P, Klescz F, Lohoff M, Vogelmeier C, Bals R. The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int Immunol 2006;18:1729–36.
   PubMed Web of Science ®Google Scholar
• Nell MJ, Tjabringa GS, Wafelman AR, Verrijk R, Hiemstra PS, Drijfhout JW, Grote JJ. Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application. Peptides 2006;27:649–60.
   PubMed Web of Science ®Google Scholar
• Hasty DL, Meron-Sudai S, Cox KH, Nagorna T, Ruiz-Bustos E, Losi E. Monocyte and macrophage activation by lipoteichoic acid is independent of alanine and is potentiated by hemoglobin. J Immunol 2006;176:5567–76.
   PubMed Web of Science ®Google Scholar
• Cox KH, Ofek I, Hasty DL. Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on Toll-like receptors 2 and 4. Infect Immun 2007;75:2638–41.
   PubMed Web of Science ®Google Scholar
• Traub S, von Aulock S, Hartung T, Hermann C. MDP and other muropeptides – direct and synergistic effects on the immune system. J Endotoxin Res 2006;12:69–85.
   PubMedGoogle Scholar
• Meron-Sudai S, Matityahou A, Keisari Y, Cox KH, Hasty DL, Ofek I. Lipoteichoic acid synergizes with glycosphingolipids to potently stimulate secretion of interleukin-6 from human blood cells. Clin Vaccine Immunol 2008;15:1309–15.
   PubMedGoogle Scholar
• Kim HJ, Yang JS, Woo SS, Kim SK, Yun CH, Kim KK, Han SH. Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of proinflammatory cytokines. J Leukoc Biol 2007;81:983–9.
   PubMed Web of Science ®Google Scholar
• Gustafsson A, Olin AI, Ljunggren L. LPS interactions with immobilized and soluble antimicrobial peptides. Scand J Clin Invest 2010;70:194–200.
   PubMed Web of Science ®Google Scholar
• Ginsburg I. Role of lipoteichoic acid in infection and inflammation. Lancet Infect Dis 2002;2:171–9.
   PubMed Web of Science ®Google Scholar
• Nakayama GR, Caton MC, Nova MP, Parandoosh Z. Assessment of the Alamar Blue assay for cellular growth and viability in vitro. J Immunol Methods 1997;204:205–8.
   PubMed Web of Science ®Google Scholar
• Fischer W, Markwitz S, Labischinski H. Small-angle X-ray scattering analysis of pneumococcal lipoteichoic acid phase structure. Eur J Biochem 1997;244:913–7.
   PubMedGoogle Scholar
• Sorensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 2001;97:3951–9.
   PubMed Web of Science ®Google Scholar
• Mayo KH, Haseman J, Young HC, Mayo JW. Structure-function relationships in novel peptide dodecamerswith broad-spectrum bactericidal and endotoxin-neutralizing activities. Biochem J 2000;349 Pt 3:717–28.
   PubMed Web of Science ®Google Scholar
• Sugiyama A, Arakaki R, Ohnishi T, Arakaki N, Daikuhara Y, Takada H. Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. Infect Immun 1996;64:1426–31.
   PubMed Web of Science ®Google Scholar
• Gao JJ, Xue Q, Zuvanich EG, Haghi KR, Morrison DC. Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect Immun 2001;69:751–7.
   PubMed Web of Science ®Google Scholar
• Morath S, Geyer A, Spreitzer I, Hermann C, Hartung T. Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations. Infect Immun 2002;70: 938–44.
   Google Scholar
• Kusunoki T, Hailman E, Juan TS, Lichenstein HS, Wright SD. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses. J Exp Med 1995; 182:1673–82.
   PubMed Web of Science ®Google Scholar
• Morath S, Geyer A, Hartung T. Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J Exp Med 2001;193:393–7.
   PubMed Web of Science ®Google Scholar
• Deininger S, Traub S, Aichele D, Rupp T, Baris T, Moller HM. Presentation of lipoteichoic acid potentiates its inflammatory activity. Immunobiology 2008;213:519–29.
   PubMed Web of Science ®Google Scholar
• Draing C, Sigel S, Deininger S, Traub S, Munke R, Mayer C. Cytokine induction by Gram-positive bacteria. Immunobiology 2008;213:285–96.
   PubMed Web of Science ®Google Scholar
• Stromstedt AA, Pasupuleti M, Schmidtchen A, Malmsten M. Evaluation of strategies for improving proteolytic resistance of antimicrobial peptides by using variants of EFK17, an internal segment of LL-37. Antimicrob Agents Chemother 2009;53:593–602.
   PubMed Web of Science ®Google Scholar
• Wang Y, Agerberth B, Lothgren A, Almstedt A, Johansson J. Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37. J Biol Chem 1998;273:33115–8.
   PubMed Web of Science ®Google Scholar