Potential of whole blood coagulation reconstitution by desmopressin and fibrinogen under conditions of hypothermia and acidosis – an in vitro study using rotation thrombelastometry

References

• Kobbe P, Lichte P, Wellmann M, Hildebrand F, Nast-Kolb D, Waydhas C, Oberbeck R. [Impact of hypothermia on the severely injured patient]. Unfallchirurg 2009;112:1055–61.
   PubMed Web of Science ®Google Scholar
• Wang HE, Callaway CW, Peitzman AB, Tisherman SA. Admission hypothermia and outcome after major trauma. Crit Care Med 2005;33:1296–301.
   PubMed Web of Science ®Google Scholar
• Dirkmann D, Hanke AA, Gorlinger K, Peters J. Hypothermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg 2008;106:1627–32.
   PubMed Web of Science ®Google Scholar
• Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 2008;65:951–60.
   PubMedGoogle Scholar
• Martini WZ, Pusateri AE, Uscilowicz JM, Delgado AV, Holcomb JB. Independent contributions of hypothermia and acidosis to coagulopathy in swine. J Trauma 2005;58:1002–9.
   PubMedGoogle Scholar
• Martini WZ. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. J Trauma 2009;67:202–8.
   PubMedGoogle Scholar
• Ramaker AJ, Meyer P, van der MJ, Struys MM, Lisman T, van OW, Hendriks HG. Effects of acidosis, alkalosis, hyperthermia and hypothermia on haemostasis: results of point-of-care testing with the thromboelastography analyser. Blood Coagul Fibrinolysis 2009;20:436–9.
   PubMed Web of Science ®Google Scholar
• Staab DB, Sorensen VJ, Fath JJ, Raman SB, Horst HM, Obeid FN. Coagulation defects resulting from ambient temperature-induced hypothermia. J Trauma 1994;36:634–8.
   PubMedGoogle Scholar
• Valeri CR, MacGregor H, Cassidy G, Tinney R, Pompei F. Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit Care Med 1995;23: 698–704.
   PubMed Web of Science ®Google Scholar
• Mannucci PM. Desmopressin (DDAVP) in the treatment of bleeding disorders: the first twenty years. Haemophilia 2000;6 Suppl 1:60–7.
   Web of Science ®Google Scholar
• Balduini CL, Noris P, Belletti S, Spedini P, Gamba G. In vitro and in vivo effects of desmopressin on platelet function. Haematologica 1999;84:891–6.
   PubMed Web of Science ®Google Scholar
• Wun T, Paglieroni TG, Lachant NA. Desmopressin stimulates the expression of P-selectin on human platelets in vitro. J Lab Clin Med 1995;126:401–9.
   PubMed Web of Science ®Google Scholar
• Wun T, Paglieroni T, Lachant NA. Physiologic concentrations of arginine vasopressin activate human platelets in vitro. Br J Haematol 1996;92:968–72.
   PubMed Web of Science ®Google Scholar
• Franchini M. The use of desmopressin as a hemostatic agent: a concise review. Am J Hematol 2007;82:731–5.
   PubMed Web of Science ®Google Scholar
• Weber CF, Dietrich W, Spannagl M, Hofstetter C, Jambor C. A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery. 15: Anesth Analg. 2010 Mar 1;110(3):702–7. Epub 2009 Dec 30.
   PubMed Web of Science ®Google Scholar
• Rezende-Neto JB, Rizoli SB, Andrade MV, Ribeiro DD, Lisboa TA, Camargos ER, Martins P, Cunha-Melo JR. Permissive hypotension and desmopressin enhance clot formation. J Trauma 2010;68:42–50.
   PubMedGoogle Scholar
• Ying CL, Tsang SF, Ng KF. The potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis – an in vitro study using PFA-100. Resuscitation 2008;76:129–33.
   PubMed Web of Science ®Google Scholar
• Hanke AA, Dellweg C, Kienbaum P, Weber CF, Gorlinger K, Rahe-Meyer N. Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. Anaesthesia 2010;65:688–91.
   PubMed Web of Science ®Google Scholar
• Brenni M, Worn M, Bruesch M, Spahn DR, Ganter MT. Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. Acta Anaesthesiol Scand 2010;54:111–7.
   PubMed Web of Science ®Google Scholar
• Fries D, Innerhofer P, Schobersberger W. Time for changing coagulation management in trauma-related massive bleeding. Curr Opin Anaesthesiol 2009;22:267–74.
   PubMed Web of Science ®Google Scholar
• Grottke O, Braunschweig T, Henzler D, Coburn M, Tolba R, Rossaint R. Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury. Crit Care 2010;14:R62.
   Web of Science ®Google Scholar
• Lier H, Krep H, Schochl H. [Coagulation management in the treatment of multiple trauma]. Anaesthesist 2009;58: 1010–26.
   PubMed Web of Science ®Google Scholar
• Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010;14:R55.
   PubMed Web of Science ®Google Scholar
• Schochl H, Forster L, Woidke R, Solomon C, Voelckel W. Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. Anaesthesia 2010;65:199–203.
   PubMed Web of Science ®Google Scholar
• Waydhas C, Gorlinger K. [Coagulation management in multiple trauma]. Unfallchirurg 2009;112:942–50.
   PubMed Web of Science ®Google Scholar
• Lang T, von DM. [Possibilities and limitations of thrombelastometry/-graphy]. Hamostaseologie 2006;26:S20–9.
   PubMedGoogle Scholar
• Fries D, Haas T, Klingler A, Streif W, Klima G, Martini J, Wagner-Berger H, Innerhofer P. Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy – a porcine model. Br J Anaesth 2006;97:460–7.
   PubMed Web of Science ®Google Scholar
• Lang T, Johanning K, Metzler H, Piepenbrock S, Solomon C, Rahe-Meyer N, Tanaka KA. The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesth Analg 2009;108:751–8.
   PubMed Web of Science ®Google Scholar
• Thibonnier M, Hinko A, Pearlmutter AF. The human platelet vasopressin receptor and its intracellular messengers: key role of divalent cations. J Cardiovasc Pharmacol 1987;10:24–9.
   PubMed Web of Science ®Google Scholar
• Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma 1997;42:857–61.
   PubMed Web of Science ®Google Scholar
• Ferrara A, MacArthur JD, Wright HK, Modlin IM, McMillen MA. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg 1990;160:515–8.
   PubMed Web of Science ®Google Scholar
• Grottke O, Henzler D, Spahn DR, Rossaint R. [Coagulopathy in multiple trauma: new aspects of therapy]. Anaesthesist 2007;56:95–106.
   PubMedGoogle Scholar
• Siller-Matula JM, Gouya G, Wolzt M, Jilma B. Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers. Thromb Haemost 2009;102:397–403.
   PubMed Web of Science ®Google Scholar
• Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, Simanski C, Neugebauer E, Bouillon B. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 2007;38:298–304.
   PubMed Web of Science ®Google Scholar
• Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007;13:680–5.
   PubMed Web of Science ®Google Scholar
• Hildebrand F, Probst C, Frink M, Huber-Wagner S, Krettek C. [Importance of hypothermia in multiple trauma patients]. Unfallchirurg 2009;112:959–64.
   PubMed Web of Science ®Google Scholar
• Hilbert P, Struck MF, Stuttmann R. Desmopressin (Minirin®) in multiple trauma – A case report. 37: Z Orthop Unfall. 2010 May;148(3):338–42.
   PubMed Web of Science ®Google Scholar
• Tam LK, Ng KF. The role of desmopressin in a patient with severe coagulopathy aggravated by mild therapeutic hypothermia. Resuscitation 2009;80:1216–7.
   PubMed Web of Science ®Google Scholar
• Fries D. [Dilutional coagulopathy: development, diagnostic options and management]. Hamostaseologie 2006;26:S15–19.
   Google Scholar
• Fries D, Innerhofer P, Reif C, Streif W, Klingler A, Schobersberger W, Velik-Salchner C, Friesenecker B. The effect of fibrinogen substitution on reversal of dilutional coagulopathy: an in vitro model. Anesth Analg 2006;102:347–51.
   PubMed Web of Science ®Google Scholar
• Mannucci PM, Aberg M, Nilsson IM, Robertson B. Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs. Br J Haematol 1975;30:81–93.
   PubMed Web of Science ®Google Scholar
• Mannucci PM, Pareti FI, Holmberg L, Nilsson IM, Ruggeri ZM. Studies on the prolonged bleeding time in von Willebrand's disease. J Lab Clin Med 1976;88:662–71.
   PubMed Web of Science ®Google Scholar
• Hezard N, Jallu V, Garnotel R, Kaplan C, Nguyen P. DDAVP infusion can modify VASP phosphorylation in human platelets. J Thromb Haemost 2004;2:672–3.
   PubMed Web of Science ®Google Scholar
• Fenger-Eriksen C, Ingerslev J, Sorensen B. Fibrinogen concentrate – a potential universal hemostatic agent. Expert Opin Biol Ther 2009;9:1325–33.
   PubMed Web of Science ®Google Scholar
• Fenger-Eriksen C, Jensen TM, Kristensen BS, Jensen KM, Tonnesen E, Ingerslev J, Sorensen B. Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 2009;7:795–802.
   PubMed Web of Science ®Google Scholar
• Velik-Salchner C, Haas T, Innerhofer P, Streif W, Nussbaumer W, Klingler A, Klima G, Martinowitz U, Fries D. The effect of fibrinogen concentrate on thrombocytopenia. J Thromb Haemost 2007;5:1019–25.
   PubMed Web of Science ®Google Scholar
• Schochl H, Posch A, Hanke A, Voelckel W, Solomon C. High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. 47: Scand J Clin Lab Invest. 2010 Oct;70(6):453–7.
   PubMed Web of Science ®Google Scholar
• Coppola A, Di MG. Desmopressin in inherited disorders of platelet function. Haemophilia 2008;14(Suppl. 1):31–9.
   PubMed Web of Science ®Google Scholar
• Haas T, Fries D, Velik-Salchner C, Reif C, Klingler A, Innerhofer P. The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution. Anesth Analg 2008;106: 1360–5, table.
   PubMed Web of Science ®Google Scholar
• Martini WZ, Dubick MA, Wade CE, Holcomb JB. Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med 2007;35:1568–74.
   PubMed Web of Science ®Google Scholar
• Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010;14:R52.
   PubMed Web of Science ®Google Scholar