Ozone therapy prevents renal inflammation and fibrosis in a rat model of acute pyelonephritis

References

• Pavlova EL, Lilova MI, Savov VM. Oxidative stress in children with kidney disease. Pediatr Nephrol 2005;20: 1599–604.
   PubMed Web of Science ®Google Scholar
• Mundi H, Bjorksten B, Svanborg C, Ohman L, Dahlgren C. Extracellular release of reactive oxygen species from human neutrophils upon interaction with Escherichia coli strains causing renal scarring. Infect Immun 1991;59:4168–72.
   PubMed Web of Science ®Google Scholar
• Biyikli NK, Tugtepe H, Sener G, Velioglu-Ogunc A, Cetinel S, Midillioglu S, Gedik N, Yegen BC. Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism. Peptides 2006;27: 2249–57.
   PubMed Web of Science ®Google Scholar
• Webb NJ,Brenchley PE. Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis. Nephron Exp Nephrol 2004;96:e1–6.
   Google Scholar
• Roberts JA. Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). Curr Top Pathol 1995; 88:265–87.
   PubMedGoogle Scholar
• Gupta A, Sharma S, Nain CK, Sharma BK, Ganguly NK. Reactive oxygen species-mediated tissue injury in experimental ascending pyelonephritis. Kidney Int 1996;49: 26–33.
   PubMed Web of Science ®Google Scholar
• Oh-oka H, Fujisawa M, Okada H, Arakawa S, Kamidono S. Differential involvement of reactive oxygen species and myeloperoxidase in oxygen-dependent killing of urinary tract bacterial isolates by polymorphonuclear leukocytes. Urol Res 2001;29:423–7.
   PubMedGoogle Scholar
• Mittal R, Sharma S, Chhibber S, Harjai K. Contribution of free radicals to Pseudomonas aeruginosa induced acute pyelonephritis. Microb Pathog 2008;45:323–30.
   PubMed Web of Science ®Google Scholar
• Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm 2004; 13:3–11.
   PubMed Web of Science ®Google Scholar
• Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425–35.
   PubMed Web of Science ®Google Scholar
• Souza YM, Fontes B, Martins JO, Sannomiya P, Brito GS, Younes RN, Rasslan S. Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats. Clinics (Sao Paulo) 2010;65:195–202.
   PubMed Web of Science ®Google Scholar
• Re L, Mawsouf MN, Menendez S, Leon OS, Sanchez GM, Hernandez F. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch Med Res 2008;39:17–26.
   PubMed Web of Science ®Google Scholar
• Oter S,Korkmaz A. Relevance of hyperbaric oxygen to ozone therapy. Arch Med Res 2006;37:917–8.
   PubMed Web of Science ®Google Scholar
• Bocci V, Zanardi I, Travagli V. Has oxygen-ozone therapy a future in medicine? J Exp Integr Med 2011;1:5–11.
   Google Scholar
• Ajamieh H, Merino N, Candelario-Jalil E, Menendez S, Martinez-Sanchez G, Re L, Giuliani A, Leon OS. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacol Res 2002;45:333–9.
   PubMed Web of Science ®Google Scholar
• Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, Chen Z. Similarities between ozone oxidative preconditioning and ischemic preconditioning in renal ischemia/reperfusion injury. Arch Med Res 2008;39:169–78.
   PubMed Web of Science ®Google Scholar
• Uysal B, Yasar M, Ersoz N, Coskun O, Kilic A, Cayc T, Kurt B, Oter S, Korkmaz A, Guven A. Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis. Pancreas 2010;39:9–15.
   PubMed Web of Science ®Google Scholar
• Guven A, Gundogdu G, Sadir S, Topal T, Erdogan E, Korkmaz A, Surer I, Ozturk H. The efficacy of ozone therapy in experimental caustic esophageal burn. J Pediatr Surg 2008;43:1679–84.
   PubMed Web of Science ®Google Scholar
• Guven A, Gundogdu G, Vurucu S, Uysal B, Oztas E, Ozturk H, Korkmaz A. Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats. J Pediatr Surg 2009;44:1730–5.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265–75.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–8.
   PubMed Web of Science ®Google Scholar
• Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464–78.
   PubMed Web of Science ®Google Scholar
• Durak I, Yurtarslanl Z, Canbolat O, Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta 1993;214:103–4.
   PubMed Web of Science ®Google Scholar
• Paglia DE,Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158–69.
   PubMed Web of Science ®Google Scholar
• Chatterjee PK, Patel NS, Kvale EO, Cuzzocrea S, Brown PA, Stewart KN, Mota-Filipe H, Thiemermann C. Inhibition of inducible nitric oxide synthase reduces renal ischemia/ reperfusion injury. Kidney Int 2002;61:862–71.
   PubMed Web of Science ®Google Scholar
• Alrashed M, Abougoush M, Akgul EO, Erbil MK. Detection method of serum and urine neopterin levels by high performance liquid chromatography. Gulhane MJ 2002;44:273–7.
   Google Scholar
• Pecile P, Miorin E, Romanello C, Falleti E, Valent F, Giacomuzzi F, Tenore A. Procalcitonin: a marker of severity of acute pyelonephritis among children. Pediatrics 2004; 114:e249–54.
   PubMed Web of Science ®Google Scholar
• Fuchs D, Weiss G, Wachter H. Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. Int Arch Allergy Immunol 1993;101:1–6.
   PubMed Web of Science ®Google Scholar
• Couser WG. Pathogenesis of glomerular damage in glomerulonephritis. Nephrol Dial Transplant 1998;13 (Suppl. 1):10–5.
   PubMedGoogle Scholar
• Hosseini F, Naseri MK, Badavi M, Ghaffari MA, Shahbazian H, Rashidi I. Effect of beta carotene on lipid peroxidation and antioxidant status following renal ischemia/reperfusion injury in rat. Scand J Clin Lab Invest 2010;70:259–63.
   PubMed Web of Science ®Google Scholar
• Gupta R, Verma I, Sharma S, Ganguly NK. Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis – role of free radical scavengers. Comp Immunol Microbiol Infect Dis 2004;27:225–34.
   PubMed Web of Science ®Google Scholar
• Imamoglu M, Cay A, Cobanoglu U, Bahat E, Karahan C, Tosun I, Sarihan H. Effects of melatonin on suppression of renal scarring in experimental model of pyelonephritis. Urology 2006;67:1315–9.
   PubMed Web of Science ®Google Scholar
• Kavukcu S, Soylu A, Turkmen M, Sarioglu S, Buyukgebiz B, Gure A. The role of vitamin A in preventing renal scarring secondary to pyelonephritis. BJU Int 1999;83:1055–9.
   PubMed Web of Science ®Google Scholar
• Yagmurlu A, Boleken ME, Ertoy D, Ozsan M, Gokcora IH, Dindar H. Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. Urology 2003;61:1037–41.
   PubMed Web of Science ®Google Scholar
• Bocci V, Borrelli E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev 2009;29:646–82.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Clement MV, Long LH. Hydrogen peroxide in the human body. FEBS Lett 2000;486:10–3.
   PubMed Web of Science ®Google Scholar
• Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol 2002;3:1129–34.
   PubMed Web of Science ®Google Scholar
• Zamora ZB, Borrego A, Lopez OY, Delgado R, Gonzalez R, Menendez S, Hernandez F, Schulz S. Effects of ozone oxidative preconditioning on TNF-alpha release and antioxidant-prooxidant intracellular balance in mice during endotoxic shock. Mediators Inflamm 2005;2005:16–22.
   PubMed Web of Science ®Google Scholar
• Madej P, Plewka A, Madej JA, Nowak M, Plewka D, Franik G, Golka D. Ozonotherapy in an induced septic shock. I. Effect of ozonotherapy on rat organs in evaluation of free radical reactions and selected enzymatic systems. Inflammation 2007;30:52–8.
   PubMed Web of Science ®Google Scholar
• Bette M, Nusing RM, Mutters R, Zamora ZB, Menendez S, Schulz S. Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum. Shock 2006;25:23–9.
   PubMed Web of Science ®Google Scholar
• Calunga JL, Zamora ZB, Borrego A, Rio S, Barber E, Menendez S, Hernandez F, Montero T, Taboada D. Ozone therapy on rats submitted to subtotal nephrectomy: role of antioxidant system. Mediators Inflamm 2005;2005:221–7.
   PubMed Web of Science ®Google Scholar
• Clavo B, Catala L, Perez JL, Rodriguez V, Robaina F. Ozone therapy on cerebral blood flow: a preliminary report. Evid Based Complement Alternat Med 2004;1:315–9.
   PubMed Web of Science ®Google Scholar
• Di Paolo N, Bocci V, Cappelletti F, Petrini G, Gaggiotti E. Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO). Int J Artif Organs 2002;25:1194–8.
   PubMed Web of Science ®Google Scholar
• Peralta C, Xaus C, Bartrons R, Leon OS, Gelpi E, Rosello-Catafau J. Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion. Free Radic Res 2000;33:595–605.
   PubMed Web of Science ®Google Scholar
• Altinel O, Demirbas S, Cakir E, Yaman H, Ozerhan IH, Duran E, Cayci T, Akgul EO, Ersoz N, Uysal B, Kurt B, Yasar M, Oter S, Peker Y. Comparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis. Scand J Clin Lab Invest 2011;71:185–92.
   PubMed Web of Science ®Google Scholar
• Bocci V, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini E, Gerli R. Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. J Biol Regul Homeost Agents 1998;12:67–75.
   PubMed Web of Science ®Google Scholar
• Ohtsuka H, Ogata A, Terasaki N, Koiwa M, Kawamura S. Changes in leukocyte population after ozonated autohemoadministration in cows with inflammatory diseases. J Vet Med Sci 2006;68:175–8.
   PubMed Web of Science ®Google Scholar
• Benador N, Siegrist CA, Gendrel D, Greder C, Benador D, Assicot M, Bohuon C, Girardin E. Procalcitonin is a marker of severity of renal lesions in pyelonephritis. Pediatrics 1998;102:1422–5.
   PubMed Web of Science ®Google Scholar