111
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

Impaired hormonal counterregulation to biochemical hypoglycaemia does not explain the high incidence of severe hypoglycaemia during pregnancy in women with type 1 diabetes

, , , , , & show all
Pages 67-74 | Received 27 Apr 2012, Accepted 18 Oct 2012, Published online: 29 Nov 2012

References

  • Evers IM, ter Braak EW, de Valk HW, van Der SB, Janssen N, Visser GH. Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy. Diabetes Care 2002;25:554–9.
  • Nielsen LR, Pedersen-Bjergaard U, Thorsteinsson B, Johansen M, Damm P, Mathiesen ER. Hypoglycemia in pregnant women with type 1 diabetes: predictors and role of metabolic control. Diabetes Care 2008;31:9–14.
  • Kimmerle R, Heinemann L, Delecki A, Berger M. Severe hypoglycemia incidence and predisposing factors in 85 pregnancies of type I diabetic women. Diabetes Care 1992;15:1034–7.
  • Bolli G, de Feo P, Compagnucci P, Angeletti G, Santeusanio F, Brunetti P, Gerich JE. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 1983;32:134–41.
  • Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 1973;182:171–3.
  • Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988;37:901–7.
  • Diamond MP, Reece EA, Caprio S, Jones TW, Amiel S, DeGennaro N, Laudano A, Addabbo M, Sherwin RS, Tamborlane WV. Impairment of counterregulatory hormone responses to hypoglycemia in pregnant women with insulin-dependent diabetes mellitus. Am J Obstet Gynecol 1992;166:70–7.
  • Rosenn BM, Miodovnik M, Khoury JC, Siddiqi TA. Counterregulatory hormonal responses to hypoglycemia during pregnancy. Obstet Gynecol 1996;87:568–74.
  • Bjorklund A, Adamson U, Andreasson K, Carlström K, Hennen G, Igout A, Lins PE, Westgren M. Hormonal counterregulation and subjective symptoms during induced hypoglycemia in insulin-dependent diabetes mellitus patients during and after pregnancy. Acta Obstet Gynecol Scand 1998;77:625–34.
  • Nisell H, Persson B, Hanson U, Lunell NO, Nylund L, Sarby B, Thronström S. Hormonal, metabolic, and circulatory responses to insulin-induced hypoglycemia in pregnant and nonpregnant women with insulin-dependent diabetes. Am J Perinatol 1994;11:231–6.
  • Buchanan TA, Schemmer JK, Freinkel N. Embryotoxic effects of brief maternal insulin-hypoglycemia during organogenesis in the rat. J Clin Invest 1986;78:643–9.
  • Smoak IW, Sadler TW. Embryopathic effects of short-term exposure to hypoglycemia in mouse embryos in vitro. Am J Obstet Gynecol 1990;163:619–24.
  • Holden KP, Jovanovic L, Druzin ML, Peterson CM. Increased fetal activity with low maternal blood glucose levels in pregnancies complicated by diabetes. Am J Perinatol 1984;1:161–4.
  • Stangenberg M, Persson B, Stange L, Carlstrom K. Insulin-induced hypoglycemia in pregnant diabetics. Maternal and fetal cardiovascular reactions. Acta Obstet Gynecol Scand 1983;62:249–52.
  • Nielsen LR, Damm P, Mathiesen ER. Improved pregnancy outcome in type 1 diabetic women with microalbuminuria or diabetic nephropathy: effect of intensified antihypertensive therapy? Diabetes Care 2009;32:38–44.
  • van der Hoorn FA, Boomsma F, Man in't Veld AJ, Schalekamp MA. Determination of catecholamines in human plasma by high-performance liquid chromatography: comparison between a new method with fluorescence detection and an established method with electrochemical detection. J Chromatogr 1989;487:17–28.
  • American Diabetes Association Workgroup on Hypoglycemia. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005;28:1245–9.
  • Pedersen-Bjergaard U, Pramming S, Thorsteinsson B. Recall of severe hypoglycaemia and self-estimated state of awareness in type 1 diabetes. Diabetes Metab Res Rev 2003;19:232–40.
  • Vestgaard M, Nielsen LR, Rasmussen AK, Damm P, Mathiesen ER. Thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome. Acta Obstet Gynecol Scand 2008;87:1336–42.
  • Nielsen LR, Ekbom P, Damm P, Glümer C, Frandsen MM, Jensen DM, Mathiesen ER. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care 2004;27:1200–1.
  • Amiel SA, Simonson DC, Tamborlane WV, DeFronzo RA, Sherwin RS. Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Diabetes 1987;36:518–22.
  • Mitrakou A, Mokan M, Ryan C, Veneman T, Cryer P, Gerich J. Influence of plasma glucose rate of decrease on hierarchy of responses to hypoglycemia. J Clin Endocrinol Metab 1993;76:462–5.
  • National Institute of Health and Clinical Excellence. Diabetes in Pregnancy. Management of Diabetes and its Complications from Pre-conception to the Post Natal Period. www.nice.org.uk/CG063 Nice Clinical guideline 2008.
  • Jovanovic L, Inturissi M. Assessment of glycemic control. In: Kitzmiller JL (editor) Managing preexisting diabetes mellitus for pregnancy. American Diabetes Association 2008;9–15.
  • Boomsma F, Alberts G, van Eijk L, Man in't Veld AJ, Schalekamp MA. Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. Clin Chem 1993;39:2503–8.
  • Nielsen LR, Rehfeld JF, Pedersen-Bjergaard U, Damm P, Mathiesen ER. Pregnancy-induced rise in serum C-peptide concentrations in women with type 1 diabetes. Diabetes Care 2009;32:1052–7.
  • Klose M, Lange M, Rasmussen AK, Skakkebaek NE, Hilsted L, Haug E, Andersen M, Feldt-Rasmussen U. Factors influencing the adrenocorticotropin test: role of contemporary cortisol assays, body composition, and oral contraceptive agents. J Clin Endocrinol Metab 2007;92:1326–33.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.