Urine NMR metabolomics analysis of breastfeeding biomarkers during and after pregnancy in a large prospective cohort study

References

• Kristiansen AL, Lande B, Overby NC, Andersen LF. Factors associated with exclusive breast-feeding and breast-feeding in Norway. Public Health Nutr 2010;13:2087–96.
   PubMed Web of Science ®Google Scholar
• Li R, Fein SB, Chen J, Grummer-Strawn LM. Why mothers stop breastfeeding: mothers’ self-reported reasons for stopping during the first year. Pediatrics 2008; 122(Suppl. 2):S69–76.
   Web of Science ®Google Scholar
• Pang WW, Hartmann PE. Initiation of human lactation: secretory differentiation and secretory activation. J Mammary Gland Biol Neoplasia 2007;12:211–21.
   PubMed Web of Science ®Google Scholar
• Hartmann PE, Whitely JL, Willcox DL. Lactose in plasma during lactogenesis, established lactation and weaning in sows. J Physiol - London 1984;347:453–63.
   PubMed Web of Science ®Google Scholar
• Strand FT, Johnston CS. Urinary lactose as an index of lactation performance. J Am Diet Assoc 1992;92:83–4.
   PubMedGoogle Scholar
• Flynn FV, Harper C, Demayo P. Lactosuria and glycosuria in pregnancy and the puerperium. Lancet 1953;265: 698–704.
   PubMed Web of Science ®Google Scholar
• Date JW. The excretion of lactose and some monosaccharides during pregnancy and lactation. Scand J Clin Lab Invest 1964;16:589–96.
   PubMed Web of Science ®Google Scholar
• Hallgren P, Lindberg BS, Lundblad A. Quantitation of some urinary oligosaccharides during pregnancy and lactation. J Biolog Chem 1977;252:1034–40.
   PubMed Web of Science ®Google Scholar
• Murtaugh MA, Kerver J, Tangney CC. Urinary lactose excretion increases with estimated milk production. J Pediatr Gastroenterol Nutr 1996;23.
   PubMed Web of Science ®Google Scholar
• Shibano K, Kawamura S, Hakamada R, Kawamura Y. The relationship between changes in serum glycine and alanine concentrations in non-essential amino acid and milk production in the transition period in dairy cows. J Vet Med Sci 2005;67:191–3.
   PubMed Web of Science ®Google Scholar
• Kalkwarf HJ, Kalis M. Urinary lactose: changes postpartum and relation with breast milk production. Am J Clin Nutr 1997;65:744–9.
   PubMed Web of Science ®Google Scholar
• Wijndaele K, Lakshman R, Landsbaugh JR, Ong KK, Ogilvie D. Determinants of early weaning and use of unmodified cow's milk in infants: a systematic review. J Am Diet Assoc 2009;109:2017–28.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature 2008;455:1054–6.
   PubMed Web of Science ®Google Scholar
• Holmes E, Wilson ID, Nicholson JK. Metabolic phenotyping in health and disease. Cell 2008;134:714–7.
   PubMed Web of Science ®Google Scholar
• Schlotterbeck G, Ross A, Dieterle F, Senn H. Metabolic profiling technologies for biomarker discovery in biomedicine and drug development. Pharmacogenomics 2006;7: 1055–75.
   PubMed Web of Science ®Google Scholar
• O’Sullivan A, He X, McNiven EM, Hinde K, Haggarty NW, Lonnerdal B, Slupsky CM. Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism. J Pediatr Gastroenterol Nutr 2013; 56:355–63.
   PubMed Web of Science ®Google Scholar
• Jenum AK, Sletner L, Voldner N, Vangen S, Morkrid K, Andersen LF, Nakstad B, Skrivarhaug T, Rognerud-Jensen OH, Roald B, Birkeland KI. The STORK Groruddalen research programme: a population-based cohort study of gestational diabetes, physical activity, and obesity in pregnancy in a multiethnic population. Rationale, methods, study population, and participation rates. Scand J Public Health 2010;38: 60–70.
   PubMed Web of Science ®Google Scholar
• Jenum AK, Morkrid K, Sletner L, Vangen S, Torper JL, Nakstad B, Voldner N, Rognerud-Jensen OH, Berntsen S, Mosdol A, Skrivarhaug T, Vardal MH, Holme I, Yajnik CS, Birkeland KI. Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study. Eur J Endocrinol 2012;166:317–24.
   PubMed Web of Science ®Google Scholar
• Sachse D, Sletner L, Mørkrid K, Jenum AK, Birkeland KI, Rise F, Piehler AP, Berg JP. Metabolic changes in urine during and after pregnancy in a large, multiethnic population-based cohort study of gestational diabetes. PLoS One 2012;7:e52399.
   Web of Science ®Google Scholar
• Holmes E, Foxall PJ, Spraul M, Farrant RD, Nicholson JK, Lindon JC. 750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease. J Pharm Biomed Anal 1997;15:1647–59.
   PubMed Web of Science ®Google Scholar
• Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De SA, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res 2009;37:D603–610.
   PubMed Web of Science ®Google Scholar
• Ulrich EL, Akutsu H, Doreleijers JF, Harano Y, Ioannidis YE, Lin J, Livny M, Mading S, Maziuk D, Miller Z, Nakatani E, Schulte CF, Tolmie DE, Kent WR, Yao H, Markley JL. BioMagResBank. Nucleic Acids Res 2008;36:D402–408.
   PubMed Web of Science ®Google Scholar
• Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, van Velzen EJJ, van Duijnhoven JPM, van Dorsten FA. Assessment of PLSDA cross validation. Metabolomics 2008;4:81–9.
   Web of Science ®Google Scholar
• Diaz SO, Barros AS, Goodfellow BJ, Duarte IF, Carreira IM, Galhano E, Pita C, Almeida MD, Gil AM. Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine. J Proteome Res 2013;12:969–79.
   PubMed Web of Science ®Google Scholar
• Ellis JK, Athersuch TJ, Thomas LD, Teichert F, Perez-Trujillo M, Svendsen C, Spurgeon DJ, Singh R, Jarup L, Bundy JG, Keun HC. Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population. BMC Med 2012;10:61.
   PubMed Web of Science ®Google Scholar
• Kassel DB, Martin M, Schall W, Sweeley CC. Urinary metabolites of L-threonine in type 1 diabetes determined by combined gas chromatography/chemical ionization mass spectrometry. Biomed Environ Mass Spectrom 1986;13: 535–40.
   PubMedGoogle Scholar
• Christensen PJ, Date JW, Schonheyder F, Volqvartz K. Amino Acids in Blood Plasma and Urine During Pregnancy. Scand J Clin Lab Invest 1957;9:54–61.
   PubMed Web of Science ®Google Scholar
• Hytten FE, Cheyne GA. The aminoaciduria of pregnancy. J Obstet Gynaecol Br Commonw 1972;79:424–32.
   PubMedGoogle Scholar
• McDonald TJ, Wu G, Nijland MJ, Jenkins SL, Nathanielsz PW, Jansson T. Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations. Br J Nutr 2012;1–7.
   Google Scholar
• Cetin I, Corbetta C, Sereni LP, Marconi AM, Bozzetti P, Pardi G, Battaglia FC. Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis. Am J Obstet Gynecol 1990;162:253–61.
   PubMed Web of Science ®Google Scholar
• Economides DL, Nicolaides KH, Gahl WA, Bernardini I, Evans MI. Plasma amino acids in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol 1989;161:1219–27.
   PubMed Web of Science ®Google Scholar
• Persaud C, Mcdermott J, Debenoist B, Jackson AA. The excretion of 5-Oxoproline in urine, as an index of glycine status, during normal-pregnancy. BJOG 1989;96:440–4.
   Google Scholar
• Glew RH, Melah G, El-Nafaty AI, Brandt Y, Morris D, VanderJagt DJ. Plasma and urinary free amino acid concentrations in preeclamptic women in northern Nigeria. Clin Chim Acta 2004;342:179–85.
   PubMed Web of Science ®Google Scholar
• Vanky E, Nordskar JJ, Leithe H, Hjorth-Hansen AK, Martinussen M, Carlsen SM. Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo. BJOG 2012;119:1403–9.
   PubMed Web of Science ®Google Scholar
• Garcia-Delgado M, Peral MJ, Cano M, Calonge ML, Ilundain AA. Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex. J Am Soc Nephrol 2001;12:1819–25.
   PubMed Web of Science ®Google Scholar
• Bertram HC, Hoppe C, Petersen BO, Duus JO, Molgaard C, Michaelsen KF. An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys. Br J Nutr 2007;97:758–63.
   PubMed Web of Science ®Google Scholar
• Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of creatine synthesis. Amino Acids 2011;40:1325–31.
   PubMed Web of Science ®Google Scholar
• Cox DB, Kent JC, Casey TM, Owens RA, Hartmann PE. Breast growth and the urinary excretion of lactose during human pregnancy and early lactation: endocrine relationships. Experim Physiol 1999;84:421–34.
   PubMed Web of Science ®Google Scholar
• Human Metabolome Database. Human Metabolome Database: Metabocard for Alpha-Lactose. Available at: http://www.hmdb.ca/metabolites/HMDB00186 (accessed 8.1.2013).
   Google Scholar
• Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM. Kidney amino acid transport. Pflugers Arch 2009;458:53–60.
   PubMed Web of Science ®Google Scholar
• Keun HC, Ebbels TM, Antti H, Bollard ME, Beckonert O, Schlotterbeck G, Senn H, Niederhauser U, Holmes E, Lindon JC, Nicholson JK. Analytical reproducibility in (1)H NMR-based metabonomic urinalysis. Chem Res Toxicol 2002;15:1380–6.
   PubMed Web of Science ®Google Scholar
• Maher AD, Zirah SFM, Holmes E, Nicholson JK. Experimental and analytical variation in human urine in H-1 NMR spectroscopy-based metabolic phenotyping studies. Anal Chem 2007;79:5204–11.
   PubMed Web of Science ®Google Scholar
• Amir LH, Donath S. A systematic review of maternal obesity and breastfeeding intention, initiation and duration. BMC Pregnancy Childbirth 2007;7:9.
   PubMedGoogle Scholar
• Schwarz EB, McClure CK, Tepper PG, Thurston R, Janssen I, Matthews KA, Sutton-Tyrrell K. Lactation and maternal measures of subclinical cardiovascular disease. Obstet Gynecol 2010;115:41–8.
   PubMed Web of Science ®Google Scholar
• Torris C, Thune I, Emaus A, Finstad SE, Bye A, Furberg AS, Barrett E, Jasienska G, Ellison P, Hjartaker A. Duration of lactation, maternal metabolic profile, and body composition in the Norwegian EBBA I-Study. Breastfeed Med 2013;8:8–15.
   PubMed Web of Science ®Google Scholar