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Scandinavian Journal of Clinical and Laboratory Investigation Volume 23, 1969 - Issue 2
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Original Article

Determination of Phenytoin in Serum in the Presence of Barbiturates, Sulthiame and Ethosuximid by Thin-Layer Chromatography

S. Vedsö Department of Clinical Chemistry, Vejle County and City Hospital, Vejle, Denmark
,
C. Rud Department of Clinical Chemistry, Vejle County and City Hospital, Vejle, Denmark
&
J. F. Place Department of Clinical Chemistry, Vejle County and City Hospital, Vejle, Denmark
Pages 175-180 | Received 13 Dec 1968, Accepted 02 Feb 1969, Published online: 08 Jul 2009

References

  • Dill W. A., Kazenko A., Wolf L. M., Glazko A. J. Studies on 5,5 diphenylhydantoin (Dilantin) in animals and man. J. Pharmacol. Exper. Ther. 1956; 118: 270
  • Lehmann J., Karamustafaoglu V. Rapid differentiation of barbiturates in blood serum by thin-layer chromatography. Scand. J. clin. Lab. Invest. 1962; 14: 554
  • Plaa G. L., Hine C. H. A method for the simultaneous determination of phenobarbital and diphenylhydantoin in blood. J. Lab. clin. Med. 1956; 47: 649
  • Svensmark O., Kristensen P. Determination of diphenylhydantoin and phenobarbital in small amounts in serum. J. Lab. clin. Med. 1963; 61: 501
  • Vendelin Olesen O. Determination by thin-layer chromatography of phenytoin in serum in the presence of barbiturates, and other anti-epileptic and various drugs. Acta pharmacol. (Kbh.) 1965; 23: 41
  • Vendelin Olesen O. A simplified method for extracting phenytoin from serum and a more sensitive staining reaction for determination by thin-layer chromatography. Acta pharmacol. (Kbh.) 1967; 25: 123
  • Vendelin Olesen O. Determination of phenobarbital and phenytoin in serum by ultraviolet spectrophotometry. Scand. J. clin. Lab. Invest. 1967; 20: 63
  • Vendelin Olesen O. Determination of sultiam (Ospolot) in serum and urine thin-layer chromatography: serum levels and urinary output in patients under long term treatment. Acta pharmacol. (Kbh.) 1968; 26: 22
  • Zaar B., Grönwall A. A micromethod for determination of barbiturates in serum as mercuric complexes. Scand. J. clin. Lab. Invest. 1961; 13: 225

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