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Scandinavian Journal of Clinical and Laboratory Investigation Volume 55, 1995 - Issue 1
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Original Article

Zinc heparin introduces a preanalytical error in the measurement of ionized calcium concentration

M. E. Lyon Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
,
M. Guajardo Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
,
T. Laha Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
,
S. Malik Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA; Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
,
P. J. Henderson Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
&
M. A. Kenny Department of Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington, USA
Pages 61-65 | Received 20 Jun 1994, Accepted 08 Nov 1994, Published online: 08 Jul 2009

References

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  • Wilson R F, Soullier G, Antonenko D. Ionized calcium levels in critically ill surgical patients. Amer Surgeon 1979; 485–90
  • Boink A BTJ, Buckley B M, Christiansen T F, Covington A K, Maas A HJ, Müller-Plathe O, et al. Recommendation on sampling, transport and storage for the determination of the concentration of ionized calcium in whole blood, plasma and serum. J Intern Fed Clin Chem 1992; 4: 147–52
  • Kahn R C, Jascott D, Carlon G C, Schweizer O, Howland W S, Goldiner P L. Massive blood replacement: correlation of ionized calcium, citrate and hydrogen ion concentration. Anesth Analg 1979; 58: 274–8
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  • Sachs C, Rabouine P, Chaneac M, Kindermans C, Dechaux M. Use of calcium-titrated sodium heparinate for ionized calcium determination on plasma and whole blood (heparinized blood sampler B-129 Radiometer). Scand J Clin Lab Invest 1991; 51: 303–8
  • Sachs C, Rabouine P, Chaneac M, Kindermans C, Dechaux M. In vitro evaluation of a heparinized blood sampler for ionized calcium measurement. Ann Clin Biochem 1991; 28: 240–4
  • Lyon M E, Guajardo M, Laha T, Malik S, Henderson P J, Kenny M A. Electrolyte balanced heparin may produce a bias in the measurement of ionized calcium concentration in specimens with abnormally low protein concentration. Clin Chim Acta, In press
  • Fogh-Andersen N, Bjerrum P J, Siggaard-Andersen O. Ionic binding, net charge and Donnan effect of human serum albumin as a function of pH. Clin Chem 1993; 39: 48–52
  • Jacob R A. Trace Elements. Textbook of clinical chemistry, N W Teitz. WB Saunders, Philadelphia 1986; 965–96
  • Mattai J, Kwak J CT. Quantitative similarity of zinc and calcium binding to heparin in excess salt solution. Biophys Chem 1988; 31: 295–9

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