Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

References

• Cooke WT, Holmes GKT. Coeliac disease. London: Churchill Livingstone; 1984. p. 27–28.
   Google Scholar
• Myrsky E, Syrjanen M, Korponay-Szabo IR, Maki M, Kaukinen K, Lindfors K. Altered small-bowel mucosal vascular network in untreated coeliac disease. Scand J Gastroenterol 2009;44:168–71.
   PubMed Web of Science ®Google Scholar
• Marzari R, Sblattero D, Florian F, Tongiorgi E, Not T, Tommasini A, Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease. J Immunol 2001;166:4170–6.
   PubMed Web of Science ®Google Scholar
• Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3:797–801.
   PubMed Web of Science ®Google Scholar
• Jones RA, Kotsakis P, Johnson TS, Chau DY, Ali S, Melino G, Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth. Cell Death Differ 2006;13:1442–53.
   PubMed Web of Science ®Google Scholar
• Haroon ZA, Hettasch JM, Lai TS, Dewhirst MW, Greenberg CS. Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. FASEB J 1999;13:1787–95.
   PubMed Web of Science ®Google Scholar
• Korponay-Szabo IR, Halttunen T, Szalai Z, Laurila K, Kiraly R, Kovacs JB, In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 2004;53:641–8.
   PubMed Web of Science ®Google Scholar
• Salmi TT, Collin P, Korponay-Szabo IR, Laurila K, Partanen J, Huhtala H, Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006;55:1746–53.
   PubMed Web of Science ®Google Scholar
• Kaukinen K, Peräaho M, Collin P, Partanen J, Woolley N, Kaartinen T, Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: a prospective and randomized clinical study. Scand J Gastroenterol 2005;40:564–72.
   PubMed Web of Science ®Google Scholar
• Myrsky E, Kaukinen K, Syrjanen M, Korponay-Szabo IR, Maki M, Lindfors K. Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis. Clin Exp Immunol 2008;152:111–19.
   PubMed Web of Science ®Google Scholar
• Di Niro R, Ziller F, Florian F, Crovella S, Stebel M, Bestagno M, Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models. BMC Biotechnol 2007;7:46.
   PubMed Web of Science ®Google Scholar
• Piacentini M, Fesus L, Sartori C, Ceru MP. Retinoic acid-induced modulation of rat liver transglutaminase and total polyamines in vivo. Biochem J 1988;253:33–8.
   PubMed Web of Science ®Google Scholar
• Piacentini M, Ceru MP, Dini L, Di Rao M, Piredda L, Thomazy V, In vivo and in vitro induction of ‘tissue’ transglutaminase in rat hepatocytes by retinoic acid. Biochim Biophys Acta 1992;1135:171–9.
   PubMedGoogle Scholar
• Piacentini M, Annicchiarico-Petruzzelli M, Oliverio S, Piredda L, Biedler JL, Melino E. Phenotype-specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: correlation with cell death by apoptosis. Int J Cancer 1992;52:271–8.
   PubMed Web of Science ®Google Scholar
• Abramoff M, Magelhaes P, Ram S. Image processing with ImageJ. Biophotonics Int 2004;11:36–42.
   Google Scholar
• Griffin M, Mongeot A, Collighan R, Saint RE, Jones RA, Coutts IG, Synthesis of potent water-soluble tissue transglutaminase inhibitors. Bioorg Med Chem Lett 2008;18:5559–62.
   PubMed Web of Science ®Google Scholar
• Myrsky E, Caja S, Simon-Vecsei Z, Korponay-Szabo IR, Nadalutti C, Collighan R, Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA. Cell Mol Life Sci 2009;66:3375–85.
   PubMed Web of Science ®Google Scholar
• Kiraly R, Vecsei Z, Demenyi T, Korponay-Szabo IR, Fesus L. Coeliac autoantibodies can enhance transamidating and inhibit GTPase activity of tissue transglutaminase: dependence on reaction environment and enzyme fitness. J Autoimmun 2006;26:278–87.
   PubMed Web of Science ®Google Scholar
• Dieterich W, Trapp D, Esslinger B, Leidenberger M, Piper J, Hahn E, Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity. Gut 2003;52:1562–6.
   PubMed Web of Science ®Google Scholar
• Esposito C, Paparo F, Caputo I, Rossi M, Maglio M, Sblattero D, Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut 2002;51:177–81.
   PubMed Web of Science ®Google Scholar
• Antonyak MA, Singh US, Lee DA, Boehm JE, Combs C, Zgola MM, Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis. J Biol Chem 2001;276:33582–7.
   PubMed Web of Science ®Google Scholar
• Tucholski J, Lesort M, Johnson GV. Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells. Neuroscience 2001;102:481–91.
   PubMed Web of Science ®Google Scholar
• Singh US, Pan J, Kao YL, Joshi S, Young KL, Baker KM. Tissue transglutaminase mediates activation of RhoA and MAP kinase pathways during retinoic acid-induced neuronal differentiation of SH-SY5Y cells. J Biol Chem 2003;278:391–9.
   PubMed Web of Science ®Google Scholar
• Melino G, Annicchiarico-Petruzzelli M, Piredda L, Candi E, Gentile V, Davies PJ, Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells. Mol Cell Biol 1994;4:6584–96.
   Google Scholar
• Oliverio S, Amendola A, Rodolfo C, Spinedi A, Piacentini M. Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis. J Biol Chem 1999;274:34123–8.
   PubMed Web of Science ®Google Scholar
• Shin DM, Jeon JH, Kim CW, Cho SY, Kwon JC, Lee HJ, Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis. J Biol Chem 2004;279:15032–9.
   PubMed Web of Science ®Google Scholar
• Currò M, Condello S, Caccamo D, Ferlazzo N, Parisi G, Ientile R. Homocysteine-induced toxicity increases TG2 expression in Neuro2a cells. Amino Acids 2009;36:725–30.
   PubMed Web of Science ®Google Scholar