823
Views
82
CrossRef citations to date
0
Altmetric
Review Article

“Pelvic radiation disease”: New understanding and new solutions for a new disease in the era of cancer survivorship

, , &
Pages 389-397 | Received 15 Sep 2010, Accepted 16 Nov 2010, Published online: 29 Dec 2010

References

  • Loftus EVJ, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther 2002;16:51–60.
  • Andreyev HJN, Amin Z, Blake P, Dearnaley D, Tait D, Vlavianos P. GI symptoms developing after pelvic radiotherapy require gastroenterological review but is that happening in the UK [abstract]? Clin Oncol 2003;15:S12.
  • Andreyev HJN. The gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut 2005;54:1051–4.
  • Hauer-Jensen M, Wang J, Denham JW. Bowel injury: current and evolving management strategies. Semin Radiat Oncol 2003;13:357–71.
  • Bacon C, Giovannucci E, Testa M, Glass T, Kawachi I. The association of treatment-related symptoms with quality-of-life outcomes for localized prostate carcinoma patients. Cancer 2002;94:862–71.
  • Bergmark K, Avall-Lundqvist E, Dickman P, Henningsohn L, Steineck G. Patient-rating of distressful symptoms after treatment for early cervical cancer. Acta Obstet Gynecol Scand 2002;81:443–50.
  • Andreyev HJN. Gastrointestinal problems following pelvic radiotherapy: the past, the present and the future. Clin Oncol 2007;19:790–9.
  • Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M, De Neve W. Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol 2008;9:367–75.
  • Al-Mamgani A, Heemsbergen WD, Peeters ST, Lebesque JV. Role of intensity-modulated radiotherapy in reducing toxicity in dose escalation for localized prostate cancer. Int J Radiat Oncol Biol Phys 2009;73:685–91.
  • Fiorino C, Valdagni R, Rancati T, Sanguineti G. Dose-volume effects for normal tissues in external radiotherapy: pelvis. Radiother Oncol 2009;93:153–67.
  • Vale CL, Tierney JF, Davidson SE, Drinkwater KJ, Symonds P. Substantial improvement in UK cervical cancer survival with chemoradiotherapy:results of a Royal College of Radiologists' audit. Clin Oncol 2010;22:590–601.
  • O'Brien PC, Hamilton CS, Denham JW, Gourlay R, Franklin CIV. Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2004;58:75–80.
  • Turesson I. The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships. Radiother Oncol 1989;15:217–26.
  • Haddock MG, Martenson JAJ. Anal carcinoma. Cancer Treat Res 1998;98:201–25.
  • Ooi B, Tjandra J, Green M. Morbidities of adjuvant chemotherapy and radiotherapy for resectable rectal cancer. Dis Colon Rectum 1999;42:403–18.
  • Denton AS, Bond SJ, Matthews S, Bentzen SM, Maher EJ, UK Link G-OG. National audit of the management and outcome of carcinoma of the cervix treated with radiotherapy in 1993. Clin Oncol (R Coll Radiol) 2000;12:347–53 and comment: 3–6.
  • Eifel P, Levenback C, Wharton J, Oswald M. Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage IB carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 1995;32:1289–300, comment: 531–4.
  • Guckenberger M, Flentje M. Late small bowel toxicity after adjuvant treatment for rectal cancer. Int J Colorectal Dis 2006;21:209–20.
  • Letschert JG, Lebesque JV, Aleman BM, Bosset JF, Horiot JC, Bartelink H, The volume effect in radiation-related late small bowel complications: results of a clinical study of the EORTC Radiotherapy Cooperative Group in patients treated for rectal carcinoma. Radiother Oncol 1994;32:116–23.
  • Mak AC, Rich TA, Schultheiss TE, Kavanagh B, Ota DM, Romsdahl MM. Late complications of postoperative radiation therapy for cancer of the rectum and rectosigmoid. Int J Radiat Oncol Biol Phys 1994;28:597–603.
  • Faithfull S. ‘Just grin and bear it and hope that it will go away’: coping with urinary symptoms from pelvic radiotherapy. Eur J Cancer Care (Engl) 1995;4:158–65.
  • Andreyev HJN. Gastrointestinal symptoms following therapeutic pelvic radiotherapy: a new understanding to improve the management of symptomatic patients. Lancet Oncol 2007;8:1007–17.
  • Denham JW, Hauer-Jensen M. The radiotherapeutic injury-a complex ‘wound’. Radiother Oncol 2002;63:129–45.
  • Dorr W, Hendry J. Consequential late effects in normal tissues. Radiother Oncol 2001;61:223–31.
  • Wedlake LJ, Thomas K, Lalji A, Blake P, Khoo VS, Tait D, Predicting late effects of pelvic radiotherapy: is there a better approach? Int J Radiat Oncol Biol Phys 2009; In press.
  • Yeoh E, Botten R, Russo A, McGowan R, Fraser R, Roos D, Chronic effects of therapeutic irradiation for localised prostatic carcinoma on anorectal function. Int J Radiat Oncol Biol Phys 2000;47:915–24.
  • Capp A, Inostroza-Ponta M, Bill D, Moscato P, Lai C, Christie D, Morbidity of prostate radiotherapy: is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial. Radiother Oncol 2009;90:400–7.
  • Olopade FO, Norman AR, Blake P, Dearnaley DP, Harrington KJ, Khoo V, The inflammatory bowel disease questionnaire and the Vaizey incontinence questionnaire are useful to identify gastrointestinal toxicity after pelvic radiotherapy. Br J Cancer 2005;92:1663–70.
  • Henderson A, Andreyev HJN, Dearnaley D, Stephens R. Patient and physician reporting of symptoms and health related quality of life in trials of treatment for early prostate cancer: considerations for future studies. Clin Oncol 2006;18:735–43.
  • Christie DRH, Denham JW, Steigler A, Lamb DS, Turner S, Mameghan H, Delayed rectal and urinary symptomatology in patients treated for prostate cancer by radiotherapy with or without short term neo-adjuvant androgen deprivation. Radiother Oncol 2005;77:117–25.
  • Heemsbergen WD, Peeters ST, Koper PC, Hoogeman MS, Lebesque JV. Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: consequential late damage. Int J Radiat Oncol Biol Phys 2006;66:3–10.
  • Koper PC, Jansen P, van Putten WL, van Os M, Wijnmaalen AJ, Lebesque JV, Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: observations of a randomised trial. Radiother Oncol 2004;73:1–9.
  • Talcott JA, Manola J, Clark JA, Kaplan I, Beard CJ, Mitchell SP, Time course and predictors of symptoms after primary prostate cancer therapy. J Clin Oncol 2003;21(21):3979–86.
  • Jellema P, van der Windt DA, Schellevis FG, van der Horst HE. Systematic review: accuracy of symptom-based criteria for diagnosis of irritable bowel syndrome in primary care. Aliment Pharmacol Ther 2009;30:695–706.
  • Denham JW, O'Brien PC, Dunstan RH, Johansen J, See A, Hamilton CS, Is there more than one late radiation proctitis syndrome. Radiother Oncol 1999;51:43–53.
  • Gillespie C, Goode C, Hackett C, Andreyev HJN. The clinical needs of patients with chronic gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther 2007;26:555–63.
  • Wang C, Leung S, Chen H, Sun L, Fang F, Huang E, The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma: evidence suggestive of consequential late effect (CQLE). Int J Radiat Oncol Biol Phys 1998;40:85–90.
  • den Hartog Jager F, van Haastert M, Batterman J, Tytgat G. The endoscopic spectrum of late radiation damage of the recto-sigmoid colon. Endoscopy 1985;17:214–16.
  • Moore E, Magrino T, Johnstone P. Rectal bleeding after radiation therapy for prostate cancer: endoscopic evaluation. Radiology 2000;217:215–18.
  • Wachter S, Gerstner N, Goldner G, Potzi R, Wambersie A, Potter R. Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma. Radiother Oncol 2000;54:11–19.
  • Williams HR, Vlavianos P, Blake P, Dearnaley DP, Tait D, Andreyev HJN. The significance of rectal bleeding after pelvic radiotherapy. Aliment Pharmacol Ther 2005;21:1085–90.
  • Section. PH, Health. NIo, Institute. NC. Common Terminology Criteria for Adverse Effects v3.0 (CTCAE). 2006.
  • Fried GM. Lessons from the surgical experience with simulators: incorporation into training and utilization in determining competency. Gastrointest Endosc Clin N Am 2006;16:425–34.
  • Temple LK, McLeod RS, Gallinger S, Wright JG. Essays on science and society. Defining disease in the genomics era. Science 2001;293:807–8.
  • Denham JW, Hauer-Jensen M, Peters LJ. Is it time for a new formalism to categorise normal tissue radiation injury? Int J Radiat Oncol Biol Phys 2001;50:1105–6.
  • Skwarchuk M, Travis E. Changes in histology and fibrogenic cytokines in irradiated colorectum of two murine strains. Int J Radiat Oncol Biol Phys 1998;42:169–78.
  • Gelfand M, Tepper M, Katz L, Binder H, Yesner R, Floch M. Acute radiation proctitis in man. Gastroenterology 1968;54:401–11.
  • Hasleton P, Carr N, Schofield P. Vascular changes in radiation bowel disease. Histopathology 1985;9:517–34.
  • Haboubi N, Schofield P, Rowland P. The light and electron microscopic features of early and late phase radiation induced proctitis. Am J Gastroenterol 1988;83:1140–4.
  • Sedgewick D, Howard G, Ferguson A. Pathogenesis of acute radiation injury in the rectum. Int J Colorectal Dis 1994;9:23–30.
  • Hovdenak N, Fajardo L, Hauer-Jensen M. Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. Int J Radiat Oncol Biol Phys 2000;48:1111–17.
  • Rubin P, Casarett G. Clinical radiation pathology. Philadelphia: WB Saunders; 1968.
  • Canney P, Dean S. Transforming growth factor beta: a promotor of late connective tissue injury following radiotherapy? Br J Radiol 1990;63:620–3.
  • Herskind C, Bamberg M, Rodemann H. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlenther Onkol 1998;174(Suppl 3):12–15.
  • Vozenin-Brotons M, Milliat F, Sabourin J, de Gouville A, Francois A, Lasser P, Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression. Int J Radiat Oncol Biol Phys 2003;56:561–72.
  • Langberg C, Hauer-Jensen M, Sung C, Kane C. Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation. Radiother Oncol 1994;32:29–36.
  • Zheng H, Wang J, Koteliansky V, Gotwals PJ, Hauer-Jensen M. Recombinant soluble transforming growth factor beta type II receptor ameliorates radiation enteropathy in mice. Gastroenterology 2000;119:1286–96.
  • Majumdar S, Li D, Ansari T, Pantelidis P, Black C, Gizycki M, Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a quantitative study of open lung biopsies. Eur Respir J 1999;14:251–7.
  • Gelber R, Goldhirsch A, Cole B, Wieand H, Schroeder G, Krook J. A quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of adjuvant radiation therapy and chemotherapy for resectable rectal cancer. J Natl Cancer Inst 1996;88:1039–45.
  • Denham JW, Peters LJ, Johansen J, Poulsen M, Lamb DS, Hindley A, Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer? Radiother Oncol 1999;52:157–64.
  • Weiss E, Hirnle P, Arnold-Bofinger H, Hess CF, Bamberg M. Therapeutic outcome and relation of acute and late side effects in the adjuvant radiotherapy of endometrial carcinoma stage I and II. Radiother Oncol 1999;53:37–44.
  • Vargas C, Martinez A, Kestin LL, Yan D, Grills I, Brabbins DS, Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys 2005;62:1297–308.
  • Cellier C, Sahmoud T, Froguel E, Adenis A, Belaiche J, Bretagne JF, Correlations between clinical activity, endoscopic severity, and biological parameters in colonic or ileocolonic Crohn's disease. A prospective multicentre study of 121 cases. Gut 1994;35:231–5.
  • Yeoh E, Horowitz M. Radiation enteritis. Surg Gynecol Obstet 1987;165:373–9.
  • Andreyev HJN, Vlavianos P, Blake P, Dearnaley D, Norman AR, Tait D. Gastrointestinal symptoms after pelvic radiotherapy: is there any role for the gastroenterologist? Int J Radiol Biol Phys 2005;62:1464–71.
  • Benton B, Norton C, Lindsay JO, Dolan S, Andreyev HJN. Can nurses manage gastrointestinal symptoms arising from pelvic radiation disease? Clin Oncol submitted.
  • Larsen A, Bjørge B, Klementsen B, Helgeland L, Wentzel-Larsen T, Fagerhol MK, Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy. Acta Oncol 2007;46:639–50.
  • Wedlake L, McGough C, Hackett C, Thomas K, Blake P, Harrington K, Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa? Aliment Pharmacol Ther 2008;27:980–7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.