Perceived food hypersensitivity: A review of 10 years of interdisciplinary research at a reference center

References

• Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007;120:638–46.
   PubMed Web of Science ®Google Scholar
• Arslan G, Kahrs GE, Lind R, Froyland L, Florvaag E, Berstad A. Patients with subjective food hypersensitivity: the value of analyzing intestinal permeability and inflammation markers in gut lavage fluid. Digestion 2004;70:26–35.
   PubMed Web of Science ®Google Scholar
• O'Leary PF, Shanahan F. Food allergies. Curr Gastroenterol Rep 2002;4:373–82.
   PubMedGoogle Scholar
• Valeur J, Morken MH, Norin E, Midtvedt T, Berstad A. Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose. Scand J Gastroenterol 2009;44:1416–23.
   PubMed Web of Science ®Google Scholar
• Lind R, Arslan G, Eriksen HR, Kahrs GE, Haug TT, Florvaag E, Subjective health complaints and modern health worries in patients with subjective food hypersensitivity. Dig Dis Sci 2005;50:1245–51.
   PubMed Web of Science ®Google Scholar
• Crowe SE, Perdue MH. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology 1992;103:1075–95.
   PubMed Web of Science ®Google Scholar
• Santos J, Bayarri C, Saperas E, Nogueiras C, Antolin M, Mourelle M, Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. Gut 1999;45:553–8.
   PubMed Web of Science ®Google Scholar
• Schwab D, Muller S, Aigner T, Neureiter D, Kirchner T, Hahn EG, Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy. Am J Gastroenterol 2003;98:1525–34.
   PubMedGoogle Scholar
• Arslan G, Ødegaard S, Elsayed S, Florvaag E, Berstad A. Food allergy and intolerance: response to intestinal provocation monitored by endosonography. Eur J Ultrasound 2002;15:29–36.
   PubMedGoogle Scholar
• Arslan G, Gilja OH, Lind R, Florvaag E, Berstad A. Response to intestinal provocation monitored by transabdominal ultrasound in patients with food hypersensitivity. Scand J Gastroenterol 2005;40:386–94.
   PubMed Web of Science ®Google Scholar
• Arslan G, Lillestøl K, Mulahasanovic A, Florvaag E, Berstad A. Food hypersensitivity reactions visualised by ultrasonography and magnetic resonance imaging in a patient lacking systemic food-specific IgE. Digestion 2006;73:111–15.
   PubMedGoogle Scholar
• Lin XP, Magnusson J, Ahlstedt S, Dahlman-Hoglund A, Hanson LL, Magnusson O, Local allergic reaction in food-hypersensitive adults despite a lack of systemic food-specific IgE. J Allergy Clin Immunol 2002;109:879–87.
   PubMedGoogle Scholar
• Lillestøl K, Helgeland L, Lied GA, Florvaag E, Valeur J, Lind R, Indication of "atopic bowel" in patients with self-reported food hypersensitivity. Aliment Pharmacol Ther 2010;31:1112–22.
   PubMed Web of Science ®Google Scholar
• Burks AW, Laubach S, Jones SM. Oral tolerance, food allergy and immunotherapy: Implications for future treatment. J Allergy Clin Immunol 2008;121:1344–50.
   PubMed Web of Science ®Google Scholar
• Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245–52.
   PubMed Web of Science ®Google Scholar
• Heath WR, Carbone FR. Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 2001;19:47–64.
   PubMed Web of Science ®Google Scholar
• Monsbakken KW, Vandvik PO, Farup PG. Perceived food intolerance in subjects with irritable bowel syndrome: etiology, prevalence and consequences. Eur J Clin Nutr 2006;60:667–72.
   PubMed Web of Science ®Google Scholar
• Chadwick VS, Chen WX, Shu D, Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002;122:1778–83.
   PubMed Web of Science ®Google Scholar
• Ohman L, Lindmark AC, Isaksson S, Posserud I, Strid H, Sjövall H, B-cell activation in patients with irritable bowel syndrome (IBS). Neurogastroenterol Motil 2009;21:644–50.
   PubMed Web of Science ®Google Scholar
• Lied GA, Petra V, Arnold B, Silke A. Dendritic cell populations in patients with self-reported food hypersensitivity. Int J Gen Medicine 2011; In press.
   Google Scholar
• Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Immunology 2002;2:465–75.
   PubMed Web of Science ®Google Scholar
• Lied GA, Berstad A. Functional and clinical aspects of the B-cell activating factor (BAFF): a narrative review. Scand J Immunol 2011;73:1–7.
   PubMed Web of Science ®Google Scholar
• Lied GA, Lillestøl K, Valeur J, Berstad A. Intestinal B cell-activating factor (BAFF): An indication of non-IgE-mediated hypersensitivity reactions to food? Aliment Pharmacol Ther 2010;32:66–73.
   PubMed Web of Science ®Google Scholar
• Park MI, Camilleri M. Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. Neurogastroenterol Motil 2006;18:595–607.
   PubMed Web of Science ®Google Scholar
• Lillestol K, Berstad A, Lind R, Florvaag E, Arslan LG, Tangen T. Anxiety and depression in patients with self-reported food hypersensitivity. Gen Hosp Psychiatry 2010;32:42–8.
   PubMed Web of Science ®Google Scholar
• Asero R, Ballmer-Weber BK, Beyer K, Conti A, Dubakiene R, Fernandez-Rivas M, IgE-mediated food allergy diagnosis: Current status and new perspectives. Mol Nutr Food Res 2007;51:135–47.
   PubMed Web of Science ®Google Scholar
• Bartra J, Sastre J, del Cuvillo A, Montoro J, Jáuregui I, Dávila I, From pollinosis to digestive allergy. J Investig Allergol Clin Immunol 2009;19:3–10.
   PubMedGoogle Scholar
• Bischoff S, Crowe SE. Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology 2005;128:1089–113.
   PubMed Web of Science ®Google Scholar
• Tobin MC, Moparty B, Farhadi A, Demeo MT, Bansal PJ, Keshavarzian A. Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol 2008;100:49–53.
   PubMed Web of Science ®Google Scholar
• Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, Perkins AC, Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 2006;101:1288–94.
   PubMed Web of Science ®Google Scholar
• Kalimo K, Lammintausta K, Klemi P, Leino R, Panula P, Kalimo H. Mast cells and IgE in intestinal mucosa in adult atopic dermatitis patients. Br J Dermatol 1988;119:579–85.
   PubMedGoogle Scholar
• Magnusson J, Lin XP, Dahlman-Höglund A, Hanson LLA, Telemo E, Magnusson O, Seasonal intestinal inflammation in patients with birch pollen allergy. J Allergy Clin Immunol 2003;112:45–50.
   PubMed Web of Science ®Google Scholar
• Pires GV, Souza HS, Elia CC, Zaltman C, Carvalho AT, Tortori CJ, Small bowel of patients with asthma and allergic rhinitis: absence of inflammation despite the presence of major cellular components of allergic inflammation. Allergy Asthma Proc 2004;25:253–9.
   PubMed Web of Science ®Google Scholar
• Wallaert B, Desreumaux P, Copin MC, Tillie I, Benard A, Colombel JF, Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma. J Exp Med 1995;182:1897–1904.
   PubMed Web of Science ®Google Scholar
• Hausteiner C, Bornschein S, Bubel E, Groben S, Lahmann C, Grosber M, Psychobehavioral predictors of somatoform disorders in patients with suspected allergies. Psychosom Med 2009;71:1004–11.
   PubMedGoogle Scholar
• Løvik M. Increased occurrence of allergy - is modern life style the cause? Tidskr Nor Legeforen 2000;120:3287–91.
   PubMedGoogle Scholar
• Sicherer SH. Food allergy. Lancet 2002;360:701–10.
   PubMed Web of Science ®Google Scholar
• Eriksen HR, Ihlebaek C. Subjective health complaints. Scan J Psychol 2002;43:101–3.
   PubMed Web of Science ®Google Scholar
• Filipkowski KB, Smyth JM, Rutchick AM, Santuzzi AM, Adya M, Petrie KJ, Do healthy people worry? Modern health worries, subjective health complaints, and health care utilization. Int J Behav Med 2010;17:182–8.
   PubMed Web of Science ®Google Scholar
• Furnham A. Are modern health worries, personality and attitudes to science associated with the use of complementary and alternative medicine? Br J Health Psychol 2007;12:229–43.
   PubMed Web of Science ®Google Scholar
• Petrie KJ, Sivertsen B, Hysing M, Broadbent E, Moss-Morris R, Eriksen HR, Thoroughly modern worries - The relationship of worries about modernity to report symptoms, health and medical care utilization. J Psychosom Res 2001;51:395–401.
   PubMed Web of Science ®Google Scholar
• Arslan G, Lind R, Olafsson S, Florvaag E, Berstad A. Quality of life in patients with subjective food hypersensitivity: applicability of the 10-item short form of the Nepean Dyspepsia Index. Dig Dis Sci 2004;49:680–7.
   PubMed Web of Science ®Google Scholar
• Jarret M, Visser R, Heitkemper M. Diet triggers symptoms in women with irritable bowel syndrome. Gasrtoenterol Nurs 2001;24:246–52.
   PubMedGoogle Scholar
• Lind R, Olafsson S, Hjelland I, Berstad A, Lied GA. Lifestyle of patients with gastrointestinal symptoms attributed to food hypersensitivity differs little from controls. Gastroenterol Nurs 2008;31:401–10.
   PubMedGoogle Scholar
• Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59:22–33.
   PubMed Web of Science ®Google Scholar
• Jarret M, Visser R, Heitkemper M. Diet triggers symptoms in women with irritable bowel syndrome. Gasrtoenterol Nurs 2001;24:246–52.
   PubMedGoogle Scholar
• Talley NJ, Spiller R. Irritable bowel syndrome: a little understood organic bowel disease? Lancet 2002;360:555–64.
   PubMed Web of Science ®Google Scholar
• Eriksen HR, Ursin H. Subjective health complaints, sensitization, and cognitive activation (stress). J Psychosom Res 2004;54:445–8.
   Google Scholar
• Lind R, Lillestøl K, Valeur J, Eriksen HR, Tangen T, Berstad A, Job stress and coping strategies in patients with subjective food hypersensitivity. Scand J Psychol 2010;51:179–84.
   PubMedGoogle Scholar
• Lind R, Lied GA, Lillestøl K, Valeur J, Berstad A. Do psychological factors predict symptom severity in patients with subjective food hypersensitivity? Scand J Gastroenterol 2010;45:835–43.
   PubMed Web of Science ®Google Scholar
• Dalton CB, Drossman DA, Hathaway JM, Bangdiwala SI. Perceptions of physicians and patients with organic and functional gastroenterological diagnoses. J Clin Gastroenterol Hepatol 2004;2:121–6.
   PubMed Web of Science ®Google Scholar
• Brosschot JF. Cognitive-emotional sensitization and somatic health complaints. Scand J Psychol 2002;43:113–21.
   PubMed Web of Science ®Google Scholar
• Overmier J. Sensitization, conditioning, and learning: can they help us understand somatisation and disability? Scand J Psychol 2002;43:105–12.
   PubMedGoogle Scholar
• Berstad A, Arslan G, Lind R, Florvaag E. Food hypersensitivity - immunologic (peripheral) or cognitive (central) sensitisation? Psychoneuroendocrinology 2005;30:983–9.
   PubMed Web of Science ®Google Scholar
• Simren M, Mansson A, Langkilde AM, Svedlund J, Abrahamsson H, Bengtsson U, Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 2001;63(2):108–15.
   PubMedGoogle Scholar
• Schmidt A, Strasburger J. Ueber die intestinale Gährungsdyspepsie der Erwachsenen (Insufficienz der Stärkeverdauung). Deutsch Arch Klin Med 1901;69:570–605.
   Google Scholar
• Hurst AF, Knott FA. Intestinal carbohydrate dyspepsia. Quart J Med 1931;24:171–80.
   Google Scholar
• Rumessen JJ. Functional bowel disease: the role of dietary carbohydrates. Eur J Gastroenterol Hepatol 1993;5:999–1008.
   Web of Science ®Google Scholar
• Marteau P, Flourie B. Tolerance to low-digestible carbohydrates: symptomatology and methods. Br J Nutr 2001;85(Suppl 1):S17-21.
   PubMedGoogle Scholar
• Levine B, Weisman S. Enzyme replacement as an effective treatment for the common symptoms of complex carbohydrate intolerance. Nutr Clin Care 2004;7:75–81.
   PubMedGoogle Scholar
• Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach. J Gastroenterol Hepatol 2010;25:252–8.
   PubMed Web of Science ®Google Scholar
• Grabitske HA, Slavin JL. Gastrointestinal effects of low-digestible carbohydrates. Crit Rev Food Sci Nutr 2009;49:327–60.
   PubMed Web of Science ®Google Scholar
• Barrett JS, Gibson PR. Clinical ramifications of malabsorption of fructose and other short-chain carbohydrates. Pract Gastroenterol 2007;31:51–65.
   Google Scholar
• Valeur J, Oines E, Morken MH, Holst JJ, Berstad A. Plasma glucagon-like peptide 1 and peptide YY levels are not altered in symptomatic fructose-sorbitol malabsorption. Scand J Gastroenterol 2008;43:1212–18.
   PubMed Web of Science ®Google Scholar
• Valeur J, Berstad A. Colonic fermentation: a neglected topic in human physiology education. Adv Physiol Educ 2010;34:22.
   Google Scholar
• Read NW. Diarrhoea: the failure of colonic salvage. Lancet 1982;2:481–3.
   PubMed Web of Science ®Google Scholar
• Binder HJ. Role of colonic short-chain fatty acid transport in diarrhea. Annu Rev Physiol 2010;72:297–313.
   PubMed Web of Science ®Google Scholar
• Hunter JO. Food allergy – or enterometabolic disorder? Lancet 1991;338:495–6.
   PubMed Web of Science ®Google Scholar
• Valeur J, Morken MH, Norin E, Midtvedt T, Berstad A. Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective? Clin Exp Gastroenterol 2010;3:65–70.
   PubMedGoogle Scholar
• Bourdu S, Dapoigny M, Chapuy E, Artigue F, Vasson MP, Dechelotte P, Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. Gastroenterology 2005;128:1996–2008.
   PubMed Web of Science ®Google Scholar
• Chey WD, Nojkov B, Rubenstein JH, Dobhan RR, Greenson JK, Cash BD. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am J Gastroenterol 2010;105:859–65.
   PubMed Web of Science ®Google Scholar
• Weaver GA, Krause JA, Miller TL, Wolin MJ. Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer. Gut 1988;29:1539–43.
   PubMed Web of Science ®Google Scholar
• Ohman L, Simren M. New insights into the pathogenesis and pathophysiology of irritable bowel syndrome. Dig Liver Dis 2007;39:201–15.
   PubMedGoogle Scholar
• Rodriguez LA, Ruigomez A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ 1999;318:565–6.
   PubMed Web of Science ®Google Scholar
• Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000;95:3503–6.
   PubMed Web of Science ®Google Scholar
• Lin HC. Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 2004;292:852–8.
   PubMed Web of Science ®Google Scholar
• Morken MH, Valeur J, Norin E, Midtvedt T, Nysaeter G, Berstad A. Antibiotic or bacterial therapy in post-giardiasis irritable bowel syndrome. Scand J Gastroenterol 2009;44:1296–1303.
   PubMed Web of Science ®Google Scholar
• Katelaris PH, Farthing MJ. Diarrhoea and malabsorption in giardiasis: a multifactorial process? Gut 1992;33:295–7.
   PubMed Web of Science ®Google Scholar
• Rhodes DY, Wallace M. Post-infectious irritable bowel syndrome. Curr Gastroenterol Rep 2006;8:327–32.
   PubMedGoogle Scholar
• Spergel JM, Mizoguchi E, Brewer JP, Martin TR, Bhan AK, Geha RS. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 1998;101:1614–22.
   PubMed Web of Science ®Google Scholar
• Vaali K, Puumalainen TJ, Lehto M, Wolff H, Rita H, Alenius H, Murine model of food allergy after epicutaneous sensitization: role of mucosal mast cell protease-1. Scand J Gastroenterol 2006;41:1405–13.
   PubMed Web of Science ®Google Scholar
• McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc Natl Acad Sci USA 2003;100:7761–6.
   PubMed Web of Science ®Google Scholar
• Akiho H, Blennerhassett P, Deng Y, Collins SM. Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 2002;282:G226–32.
   PubMed Web of Science ®Google Scholar
• Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins SM. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology 2005;129:131–41.
   PubMed Web of Science ®Google Scholar
• Valeur J, Lappalainen J, Rita H, Lin AH, Kovanen PT, Berstad A, Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model. BMC Gastroenterol 2009;9:33.
   PubMed Web of Science ®Google Scholar
• Bjørkkjær T, Brunborg LA, Arslan G, Lind R, Brun JG, Valen M, Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil. Scand J Gastroenterol 2004;39:1088–94.
   PubMed Web of Science ®Google Scholar
• Solakivi T, Kaukinen K, Kunnas T, Lehtimaki T, Maki M, Nikkari ST. Serum fatty acid profile in subjects with irritable bowel syndrome. Scand J Gastroenterol 2011;46:299–303.
   PubMed Web of Science ®Google Scholar
• Gregersen K, Lind R, Frøyland L, Berstad A, Lied GA. Effects of seal oil on meal-induced symptoms and gastric accommodation in patients with subjective food hypersensitivity: a pilot study. Clin Med Gastroenterol 2008;1:33–41.
   Google Scholar
• Gregersen K, Lind R, Valeur J, Bjørkkjær T, Berstad A, Lied GA. Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study. Int J Gen Med 2010;3:383–92.
   PubMedGoogle Scholar
• Gwee KA, Lu CL, Ghoshal UC. Epidemiology of irritable bowel syndrome in Asia: something old, something new, something borrowed. J Gastroenterol Hepatol 2009;24:1601–7.
   PubMed Web of Science ®Google Scholar