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Review Article

The enteroendocrine “letter cells” – time for a new nomenclature?

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Pages 3-12 | Received 20 Jun 2011, Accepted 21 Oct 2011, Published online: 30 Nov 2011

References

  • Ahlman H, Nilsson O. The gut as the largest endocrine organ in the body. Ann Oncol 2001;12(Suppl 2):S63–8.
  • Sundler F. GI tract, general anatomy (cells). In:. MartiniL, ed. Encyclopedia of Endocrine Diseases. Amsterdam: Elsevier; 2004. pp 208–15.
  • Gunawardene AR, Corfe BM, Staton CA. Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int J Exp Pathol 2011;92:219–31.
  • Modlin IM, Kidd M, Pfragner R, Eick GN, Champaneria MC. The functional characterization of normal and neoplastic human enterochromaffin cells. J Clin Endocrinol Metab 2006;91:2340–8.
  • Sakata I, Sakai T. Ghrelin cells in the gastrointestinal tract. Int J Pept 2010;2010:Article ID 945056.
  • Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009;150:232–8.
  • Cho YM, Kieffer TJ. K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitam Horm 2010;84:111–50.
  • von Rosenvinge EC, Raufman JP. Gastrointestinal peptides and regulation of gastric acid secretion. Curr Opin Endocrinol Diabetes Obes 2010;17:40–3.
  • Grimelius L. Methods in neuroendocrine histopathology, a methodological overview. Ups J Med Sci 2008;113:243–60.
  • Modlin IM, Champaneria MC, Bornschein J, Kidd M. Evolution of the diffuse enteroendocrine system–clear cells and cloudy origins. Neuroendocrinology 2006;84:69–82.
  • Lee May C, Kaestner KH. Gut endocrine cell development. Mol Cell Endocrinol 2010;323:70–5.
  • Bordi C, D'Adda T, Azzoni C, Ferraro G. Classification of gastric endocrine cells at the light and electron microscopical levels. Microsc Res Tech 2000;48:258–71.
  • Corleto V. Somatostatin and the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes 2010;17:63–8.
  • Bertrand P, Bertrand RL. Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci 2010;153:47–57.
  • Engelstoft MS, Egerod K, Holst B, Schwartz W. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab 2008;8:447–9.
  • Gutierrez-Aguilar R, Woods SC. Nutrition and L and K-enteroendocrine cells. Curr Opin Endocrinol Diabetes Obes 2011;18:35–41.
  • Holm M, Olbe L, Fändriks L. Intragastric CO2 and nitric oxide participate in the regulation of peptone-induced gastrin release in humans. Scand J Gastroenterol 2000;35:1260–5.
  • Rozengurt E, Sternini C. Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol 2007;7:557–62.
  • Gautam D, Han SJ, Duttaroy A, Mears D, Hamdan FF, Li JH, Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis. Diabetes Obes Metab 2007;9(Suppl 2):158–69.
  • Dunning BE, Foley JE, Ahrén B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 2005;48:1700–13.
  • Abu-Basha EA, Makowski JP, Yibchok-anun S, Hsu WH. Stimulatory effect of bradykinin (BK) on glucagon secretion from the perfused rat pancreas: Involvement of BK2 receptors. Metabolism 2000;49:1370–3.
  • La Rosa S, Uccella S, Erba S, Capella C, Sessa F. Immunohistochemical detection of fibroblast growth factor receptors in normal endocrine cells and related tumors of the digestive system. Appl Immunohistochem Mol Morphol 2001;9:319–28.
  • Leung-Theung-Long S, Roulet E, Clerc P, Escrieut C, Marchal-Victorion S, Ritz-Laser B, Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells. J Biol Chem 2005;280:7976–84.
  • Kageyama H, Funahashi H, Hirayama M, Takenoya F, Kita T, Kato S, Morphological analysis of ghrelin and its receptor distribution in the rat pancreas. Regul Pept 2005;126:67–71.
  • La Rosa S, Uccella S, Capella C, Erba S, Sessa F. Localization of hepatocyte growth factor and its receptor met in endocrine cells and related tumors of the gut and pancreas: An immunohistochemical study. Endocr Pathol 2000;11:315–29.
  • Schweiger M, Steffl M, Amselgruber WM. Cell-type specific expression of IGF-1R in porcine islet cells. Growth Horm IGF Res 2005;15:33–8.
  • Lucini C, Costagliola C, Borzacchiello G, Castaldo L. Neurotrophin 3 and its receptor TrkC immunoreactivity in glucagon cells of buffalo pancreas. Anat Histol Embryol 2003;32:253–6.
  • Emami S, Regnauld K, Ferrand N, Astesano A, Passah M, Phan H, Stimulatory transducing systems in pancreatic islet cells. Ann N Y Acad Sci 1998;865:118–31.
  • Strowski MZ, Blake AD. Function and expression of somatostatin receptors of the endocrine pancreas. Mol Cell Endocrinol 2008;286:169–79.
  • Ringström C, Dekker Nitert M, Bennet H, Fex M, Valet P, Rehfeld JF, Apelin is a novel islet peptide. Regul Pept 2010;162:44–51.
  • Leibiger IB, Brismar K, Berggren PO. Novel aspects on pancreatic beta-cell signal-transduction. Biochem Biophys Res Commun 2010;396:111–15.
  • Martínez A, Kapas S, Miller MJ, Ward Y, Cuttitta F. Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology 2000;141:406–11.
  • Yang C, Lee B, Chen T, Hsu WH. Mechanisms of bradykinin-induced insulin secretion in clonal beta cell line RINm5F. J Pharmacol Exp Ther 1997;282:1247–52.
  • Zhang Q, Köhler M, Yang SN, Zhang F, Larsson O, Berggren PO. Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation. Mol Endocrinol 2004;18:1658–69.
  • Lavine JA, Attie AD. Gastrointestinal hormones and the regulation of β-cell mass. Ann N Y Acad Sci 2010;1212:41–58.
  • Fiaschi-Taesch N, Stewart AF, Garcia-Ocaña A. Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt. Cell Biochem Biophys 2007;48:191–9.
  • Cornu M, Yan-Yang J, Jaccard E, Poussin C, Widmann C, Thorens B. Glucagon-like peptide-1 protects β-cells against apoptosis by increasing the activity of an Igf-2/Igf-1 receptor autocrine loop. Diabetes 2009;58:1816–25.
  • Rosenbaum T, Sánchez-Soto MC, Hiriart M. Nerve growth factor increases insulin secretion and barium current in pancreatic beta-cells. Diabetes 2001;50:1755–62.
  • Ehrström M, Gustafsson T, Finn A, Inhibitory effect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man. J Clin Endocrinol Metab 2005;90:2370–7.
  • Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 2008;105:5266–70.
  • Freemark M. Ontogenesis of prolactin receptors in the human fetus: roles in fetal development. Biochem Soc Trans 2001;29:38–41.
  • Wookey PJ, Lutz TA, Andrikopoulos S. Amylin in the periphery II: an updated mini-review. Scientific World Journal 2006;6:1642–55.
  • Nakamura E, Hasumura M, San Gabriel A, Uneyama H, Torii K. Functional role of calcium-sensing receptor on somatostatin release from rat gastric mucosa. Gastroenterology 2010;138(Suppl 1):S–404.
  • Sachs G, Zeng N, Prinz C. Physiology of isolated gastric endocrine cells. Annu Rev Physiol 1997;59:243–56.
  • Helander HF, Wong H, Poorkhalkali N, Walsh JH. Immunohistochemical localization of gastrin/CCK-2 receptors in the dog and guinea-pig stomach. Acta Physiol Scand 1997;159:313–20.
  • Chandra R, Liddle RA. Neural and hormonal regulation of pancreatic secretion. Curr Opin Gastroenterol 2009;25:441–6.
  • Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, PACAP type I receptor activation regulates ECL cells and gastric acid secretion. J Clin Invest 1999;104:1383–91.
  • Beales IL, Calam J. Regulation of amylin release from cultured rabbit gastric fundic mucosal cells. BMC Physiol 2003;3:13.
  • Larsson LI. Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach. Microsc Res Tech 2000;48:272–81.
  • Hansen BM, Witte AB. The role of serotonin in intestinal luminal sensing and secretion. Acta Physiol 2008;193:311–23.
  • Schäfermeyer A, Gratzl M, Rad R, Dossumbekova Sachs G, Prinz C. Isolation and receptor profiling of ileal enterochromaffin cells. Acta Physiol Scand 2004;182:53–62.
  • Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H. Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions. Peptides 2005;26:1196–206.
  • Michell AR, Debnam ES, Unwin RJ. Regulation of renal function by the gastrointestinal tract: potential role of gut-derived peptides and hormones. Annu Rev Physiol 2008;70:379–403.
  • Lambrecht NW, Yakubov I, Zer C, Sachs G. Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion. Physiol Genomics 2006;25:153–65.
  • Lindström E, Lerner UH, Håkanson R. Isolated rat stomach ECL cells generate prostaglandin E2 in response to interleukin-1β, tumor necrosis factor-α and bradykinin. Europ J Pharmacol 2001;416:255–63.
  • Tømmerås K, Bakke I, Sandvik AK, Erik Larsson E, Waldum HL. Rat parietal cells express CCK2 receptor mRNA: gene expression analysis of single cells isolated by laser-assisted microdissection. Biochem Biophys Res Commun 2002;297:335–40.
  • Kidd M, Modlin IM, Black JW, Boyce M, Culler M. A. comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul Pept 2007;143:109–17.
  • Grandi D, Shenton FC, Chazot PL, Morini G. Immunolocalization of histamine H3 receptors on endocrine cells in the rat gastrointestinal tract. Histol Histopathol 2008;23:789–98.
  • Mahr S, Neumayer N, Kolb HJ, Schepp W, Classen M, Prinz C. Growth factor effects on apoptosis of rat gastric enterochromaffin-like cells. Endocrinology 1998;139:4380–90.
  • Lu Y, Germano P, Ohning GV, Vu JP, Pisegna JR. PAC1 Deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output. J Mol Neurosci 2011;43:76–84.
  • Yang H. Central and peripheral regulation of gastric acid secretion by peptide YY. Peptides 2002;23:349–58.
  • Kazumori H, Ishihara S, Rumi MA, Ortega-Cava CF, Kadowaki Y, Kinoshita Y. Transforming growth factor-alpha directly augments histidine decarboxylase and vesicular monoamine transporter 2 production in rat enterochromaffin-like cells. Am J Physiol Gastrointest Liver Physiol 2004;286:G508–14.
  • Håkanson R, Chen D, Lindström E, Bernsand M, Norlén P. Control of secretion from rat stomach ECL cells in situ and in primary culture. Scand J Clin Lab Invest 2001;61(Suppl 234):53–60.
  • Andralojc KM, Mercalli A, Nowak KW, Albarello L, Calcagno R, Luzi L, Ghrelin-producing epsilon cells in the developing and adult human pancreas. Diabetologia 2009;52:486–93.
  • Kidd M, Hauso Ø, Drozdov I, Gustafsson BI, Modlin IM. Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells. Gastroenterology 2009;137:231–41.
  • Jensen RT, Battey JF, Spindel ER, Benya RV. International union of pharmacology. LXVIII. mammalian bombesin receptors: nomenclature, distribution, pharmacology, SIgnaling, and functions in normal and disease states. Pharmacol Rev 2008;60:1–42.
  • Geibel JP, Hebert SC. The functions and roles of the extracellular Ca2+–sensing receptor along the gastrointestinal tract. Annu Rev Physiol 2009;71:205–17.
  • Lee PT, Liao PC, Chang WC, Tseng JT. Epidermal growth factor increases the interaction between nucleolin and heterogeneous nuclear ribonucleoprotein K/Poly(C) binding protein 1 complex to regulate the gastrin mRNA turnover. Mol Biol Cell 2007;18:5004–13.
  • Chu JY, Yung WH, Chow BK. Secretin: a pleiotrophic hormone. Ann N Y Acad Sci 2006;1070:27–50.
  • Gugger M, Waser B, Kappeler A, Schonbrunn A, Reubi JC. Cellular detection of sst2A receptors in human gastrointestinal tissue. Gut 2004;53:1431–6.
  • Suzuki T, Grand E, Bowman C, Merchant JL, Todisco A, Wang L, TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol 2001;281:G1405–12.
  • Mondal MS, Yamaguchi H, Date Y, Toshinai K, Kawagoe T, Tsuruta T, Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. J Endocrinol 2006;188:49–57.
  • La Rosa S, Uccella S, Finzi G, Albarello L, Sessa F, Capella C. Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol 2003;34:18–27.
  • Taylor AI, Irwin N, McKillop AM, Patterson S, Flatt PR, Gault VA. Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. J Endocrinol 2010;207:87–93.
  • Cox HM. Neuropeptide Y receptors; antisecretory control of intestinal epithelial function Auton Neurosci. 2007;133:76–85.
  • Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab 2006;290:E550–9.
  • Kokrashvili Z, Mosinger B, Margolskee RF. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr 2009;90:822S–5S.
  • Poitras P, Peeters TL. Motilin. Curr Opin Endocrinol Diabetes Obes 2008;15:54–7.
  • Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K. Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestineJ. J Clin Endocrinol Metab 2007;92:3573–81.
  • Wang X, Wang Q, Kirk L, Ives KL, Mark Evers B. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 2006;12:5346–55.
  • Ekblad E, Sundler F. Distribution of pancreatic polypeptide and peptide YY. Peptides 2002;23:251–61.
  • Sakata I, Yang J, Lee CE, Osborne-Lawrence S, Rovinsky SA. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab 2009;297:E134–41.
  • Stengel A, Goebel M, Wang L, Taché Y. Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides 2010;31:357–69.
  • Buffa R, Capella C, Fontana P, Usellini L, Solcia E. Types of endocrine cells in the human colon and rectum. Cell Tissue Res 1978;192:227–40.
  • Weiber H, Lindström C, Lilja H, Bjartell A, Fernlund P. Immunohistochemical and in situ hybridization studies of beta-microseminoprotein in the human gastric mucosa. Histochem J 1997;29:839–45.
  • Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The “normal” endocrine cell of the gut. Changing concepts and new evidences. Ann NY Acad Sci 2004;1014:1–12.

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