Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis

References

• Shih DQ, Targan SR. Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol 2008;14:390–400.
   PubMed Web of Science ®Google Scholar
• Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 2006;3:390–407.
   PubMedGoogle Scholar
• Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004;113:1490–7.
   PubMed Web of Science ®Google Scholar
• Fuss IJ. Is the Th1/Th2 paradigm of immune regulation applicable to IBD? Inflamm Bowel Dis 2008;14(Suppl 2):S110–12.
   PubMedGoogle Scholar
• Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003;52:65–70.
   PubMed Web of Science ®Google Scholar
• Olsen T, Rismo R, Cui G, Goll R, Christiansen I, Florholmen J. TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine 2011;56:633–40.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008;57:1682–9.
   PubMed Web of Science ®Google Scholar
• Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005;353:2462–76.
   PubMed Web of Science ®Google Scholar
• Olsen T, Goll R, Cui G, Christiansen I, Florholmen J. TNF-alpha gene expression in colorectal mucosa as a predictor of remission after induction therapy with infliximab in ulcerative colitis. Cytokine 2009;46:222–7.
   PubMed Web of Science ®Google Scholar
• Arijs I, Li K, Toedter G, Quintens R, Van Lommel L, Van Steen K, Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis. Gut 2009;58:1612–19.
   PubMed Web of Science ®Google Scholar
• Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 2009;58:1629–36.
   PubMed Web of Science ®Google Scholar
• Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio BG, Caruso R, Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005;128:687–94.
   PubMed Web of Science ®Google Scholar
• Nielsen OH, Kirman I, Rudiger N, Hendel J, Vainer B. Upregulation of interleukin-12 and -17 in active inflammatory bowel disease. Scand J Gastroenterol 2003;38:180–5.
   PubMed Web of Science ®Google Scholar
• Olsen T, Goll R, Cui G, Husebekk A, Vonen B, Birketvedt GS, Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis. Scand J Gastroenterol 2007;42:1312–20.
   PubMed Web of Science ®Google Scholar
• Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008;8:337–48.
   PubMed Web of Science ®Google Scholar
• Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133–41.
   PubMed Web of Science ®Google Scholar
• Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123–32.
   PubMed Web of Science ®Google Scholar
• Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009;361:888–98.
   PubMed Web of Science ®Google Scholar
• Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007;8:345–50.
   PubMed Web of Science ®Google Scholar
• Sands BE. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology 2004;126:1518–32.
   PubMed Web of Science ®Google Scholar
• Sutherland LR, Martin F, Greer S, Robinson M, Greenberger N, Saibil F, 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987;92:1894–8.
   PubMed Web of Science ®Google Scholar
• D'Haens G, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007;132:763–86.
   PubMed Web of Science ®Google Scholar
• Cui G, Olsen T, Christiansen I, Vonen B, Florholmen J, Goll R. Improvement of real-time polymerase chain reaction for quantifying TNF-alpha mRNA expression in inflamed colorectal mucosa: an approach to optimize procedures for clinical use. Scand J Clin Lab Invest 2006;66:249–59.
   PubMed Web of Science ®Google Scholar
• Goll R, Gruber F, Olsen T, Cui G, Raschpichler G, Buset M, Helicobacter pylori stimulates a mixed adaptive immune response with a strong T-regulatory component in human gastric mucosa. Helicobacter 2007;12:185–92.
   PubMed Web of Science ®Google Scholar
• Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101–8.
   PubMed Web of Science ®Google Scholar
• Cui G, Goll R, Olsen T, Steigen SE, Husebekk A, Vonen B, Reduced expression of microenvironmental Th1 cytokines accompanies adenomas-carcinomas sequence of colorectum. Cancer Immunol Immunother 2007;56:985–95.
   PubMed Web of Science ®Google Scholar
• Schmidt C, Giese T, Hermann E, Zeuzem S, Meuer SC, Stallmach A. Predictive value of mucosal TNF transcripts in steroid refractory Crohn's disease patients receiving intensive immunosuppressive therapy. Inflamm Bowel Dis 2007;13:65–70.
   PubMed Web of Science ®Google Scholar
• Pineton de CG, Peyrin-Biroulet L, Lemann M, Colombel JF. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol 2010;7:15–29.
   PubMed Web of Science ®Google Scholar
• Florholmen J, Fries W. Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology. Scand J Gastroenterol 2011;46:1407–17.
   PubMed Web of Science ®Google Scholar
• Jürgens M, Laubender RP, Hartl F, Weidinger M, Seiderer J, Wagner J, Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis. Am J Gastroenterol 2010;105:1811–19.
   PubMed Web of Science ®Google Scholar
• Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008;14:204–12.
   PubMed Web of Science ®Google Scholar
• Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Phenotypic and functional features of human Th17 cells. J Exp Med 2007;204:1849–61.
   PubMed Web of Science ®Google Scholar
• Strober W, Zhang F, Kitani A, Fuss I, Fichtner-Feigl S. Proinflammatory cytokines underlying the inflammation of Crohn's disease. Curr Opin Gastroenterol 2010;26:310.
   PubMed Web of Science ®Google Scholar
• O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol 2009;10:603–9.
   PubMed Web of Science ®Google Scholar
• Hovhannisyan Z, Treatman J, Littman DR, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology 2011;140:957–65.
   PubMed Web of Science ®Google Scholar
• Hueber W, Sands BE, Vandemeulebroecke M, Reinisch W, Higgins PDR, Wehkamp J, Inhibition of IL-17A by secukinumab is ineffective for Crohn's disease (CD). J Crohn's Colitis 2011;5:S7.
   Google Scholar
• Mayer L. Evolving paradigms in the pathogenesis of IBD. J Gastroenterol 2010;45:9–16.
   PubMed Web of Science ®Google Scholar
• Li Z, Arijs I, De Hertogh G, Vermeire S, Noman M, Bullens D, Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis 2010;16:1299–310.
   PubMed Web of Science ®Google Scholar