Antineutrophil cytoplasmic antibodies in bile are associated with disease activity in primary sclerosing cholangitis

References

• Weismuller TJ, Lankisch TO. Medical and endoscopic therapy of primary sclerosing cholangitis. Best Pract Res Clin Gastroenterol 2011;25:741–52.
   PubMed Web of Science ®Google Scholar
• Weismuller TJ, Wedemeyer J, Kubicka S, Strassburg CP, Manns MP. The challenges in primary sclerosing cholangitis-aetiopathogenesis, autoimmunity, management and malignancy. J Hepatol 2008;48:S38–57.
   PubMed Web of Science ®Google Scholar
• Tischendorf JJ, Meier PN, Strassburg CP, Klempnauer J, Hecker H, Manns MP, et al. Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis. Scand J Gastroenterol 2006;41:1227–34.
   PubMed Web of Science ®Google Scholar
• Bergquist A, Ekbom A, Olsson R, Kornfeldt D, Loof L, Danielsson A, et al. Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. J Hepatol 2002;36:321–7.
   PubMed Web of Science ®Google Scholar
• Karlsen TH, Schrumpf E, Boberg KM. Primary sclerosing cholangitis. Best Pract Res Clin Gastroenterol 2010;24:655–66.
   PubMed Web of Science ®Google Scholar
• Hov J-R. Autoantibodies in primary sclerosing cholangitis. World J Gastroenterol 2008;14:3781.
   PubMed Web of Science ®Google Scholar
• Terjung B, Worman HJ. Anti-neutrophil antibodies in primary sclerosing cholangitis. Best Pract Res Clin Gastroenterol 2001;15:629–42.
   PubMed Web of Science ®Google Scholar
• Gencik M, Meller S, Borgmann S, Fricke H. Proteinase 3 gene polymorphisms and Wegener's granulomatosis. Kidney Int 2000;58:2473–7.
   PubMed Web of Science ®Google Scholar
• Terjung B, Spengler U. Atypical p-ANCA in PSC and AIH: a hint toward a "leaky gut"? Clin Rev Allergy Immunol 2009;36:40–51.
   PubMed Web of Science ®Google Scholar
• Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al. International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol 1999;111:507–13.
   PubMed Web of Science ®Google Scholar
• Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, et al. Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis. Hepatology 1997;25:1085–9.
   PubMed Web of Science ®Google Scholar
• Negm AA, Schott A, Vonberg RP, Weismueller TJ, Schneider AS, Kubicka S, et al. Routine bile collection for microbiological analysis during cholangiography and its impact on the management of cholangitis. Gastrointest Endosc 2010;72:284–91.
   PubMed Web of Science ®Google Scholar
• Metzger J, Negm AA, Plentz RR, Weismuller TJ, Wedemeyer J, Karlsen TH, et al. Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut 2013;62:122–30.
   PubMed Web of Science ®Google Scholar
• Vosskuhl K, Negm AA, Framke T, Weismuller T, Manns MP, Wedemeyer H, et al. Measurement of IgG4 in bile: a new approach for the diagnosis of IgG4-associated cholangiopathy. Endoscopy 2012;44:48–52.
   PubMed Web of Science ®Google Scholar
• Gotthardt D, Chahoud F, Sauer P. Primary sclerosing cholangitis: diagnostic and therapeutic problems. Dig Dis 2011;29:41–5.
   PubMed Web of Science ®Google Scholar
• Ponsioen CY, Reitsma JB, Boberg KM, Aabakken L, Rauws EA, Schrumpf E. Validation of a cholangiographic prognostic model in primary sclerosing cholangitis. Endoscopy 2010;42:742–7.
   PubMed Web of Science ®Google Scholar
• Bender R, Ziegler A, Lange S. Logistic regression. Dtsch Med Wochenschr 2007;132:e33–5.
   Google Scholar
• Worthington J, Cullen S, Chapman R. Immunopathogenesis of primary sclerosing cholangitis. Clin Rev Allergy Immunol 2005;28:93–103.
   PubMed Web of Science ®Google Scholar
• Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010;138:1102–11.
   PubMed Web of Science ®Google Scholar
• van Hoogstraten HJ, Vleggaar FP, Boland GJ, van Steenbergen W, Griffioen P, Hop WC, et al. Budesonide or prednisone in combination with ursodeoxycholic acid in primary sclerosing cholangitis: a randomized double-blind pilot study. Belgian-Dutch PSC Study Group. Am J Gastroenterol 2000;95:2015–22.
   PubMed Web of Science ®Google Scholar
• Pokorny CS, Norton ID, McCaughan GW, Selby WS. Anti-neutrophil cytoplasmic antibody: a prognostic indicator in primary sclerosing cholangitis. J Gastroenterol Hepatol 1994;9:40–4.
   PubMed Web of Science ®Google Scholar
• Bansi DS, Fleming KA, Chapman RW. Importance of antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis: prevalence, titre, and IgG subclass. Gut 1996;38:384–9.
   PubMed Web of Science ®Google Scholar
• Mulder AH, Horst G, Haagsma EB, Limburg PC, Kleibeuker JH, Kallenberg CG. Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases. Hepatology 1993;17:411–17.
   PubMed Web of Science ®Google Scholar
• European Association for the Study of the L. EASL clinical practice guidelines: management of cholestatic liver diseases. J Hepatol 2009;51:237–67.
   PubMed Web of Science ®Google Scholar
• Lankisch TO, Metzger J, Negm AA, Vosskuhl K, Schiffer E, Siwy J, et al. Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology 2011;53:875–84.
   PubMed Web of Science ®Google Scholar
• Terjung B, Sohne J, Lechtenberg B, Gottwein J, Muennich M, Herzog V, et al. p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ. Gut 2010;59:808–16.
   PubMed Web of Science ®Google Scholar
• Sung JJ, Leung JC, Tsui CP, Chung SS, Lai KN. Biliary IgA secretion in obstructive jaundice: the effects of endoscopic drainage. Gastrointest Endosc 1995;42:439–44.
   PubMed Web of Science ®Google Scholar