Nonalcoholic fatty liver disease and cholesterol gallstones: Which comes first?

References

• Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002;122:1500–11.
   PubMed Web of Science ®Google Scholar
• Shaffer EA. Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? Curr Gastroenterol Rep 2005;7:132–40.
   PubMedGoogle Scholar
• Marschall HU, Einarsson C. Gallstone disease. J Intern Med 2007;261:529–42.
   PubMed Web of Science ®Google Scholar
• Shaffer EA. Gallstone disease: epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 2006;20:981–96.
   PubMed Web of Science ®Google Scholar
• Ahmed MH, Hamad MA, Routh C, Connolly V. Statins as potential treatment for cholesterol gallstones: an attempt to understand the underlying mechanism of actions. Expert Opin Pharmacother 2011;12:2673–81.
   PubMed Web of Science ®Google Scholar
• Wang HH, Portincasa P, Wang DQ. Molecular pathophysiology and physical chemistry of cholesterol gallstones. Front Biosci 2008;13:401–23.
   PubMed Web of Science ®Google Scholar
• Wang HH, Portincasa P, Afdhal NH, Wang DQ. Lith genes and genetic analysis of cholesterol gallstone formation. Gastroenterol Clin North Am 2010;39:185–207; vii-viii.
   PubMed Web of Science ®Google Scholar
• Nakagawa S, Makino I, Ishizaki T, Dohi I. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet 1977;2:367–9.
   PubMed Web of Science ®Google Scholar
• Petroni ML, Jazrawi RP, Pazzi P, et al. Risk factors for the development of gallstone recurrence following medical dissolution. The British-Italian Gallstone Study Group. Eur J Gastroenterol Hepatol 2000;12:695–700.
   PubMed Web of Science ®Google Scholar
• Muhidin SO, Magan AA, Osman KA, Syed S, Ahmed MH. The relationship between nonalcoholic fatty liver disease and colorectal cancer: the future challenges and outcomes of the metabolic syndrome. J Obes 2012;2012:637538.
   PubMedGoogle Scholar
• Ahmed MH, Byrne CD. Non-alcoholic fatty Liver disease. In Byrne C, Wild S, editors. The Metabolic syndrome. Wiley-Blackwell; 2011. pp 245–77.
   Google Scholar
• Ahmed MH, Byrne CD. Non alcoholic steatatohepatitis and metabolic syndrome. In Byrne C, Wild S, Metabolic syndrome. Chichester, UK: John Wiley & Sons; 2005. pp 279–305.
   Google Scholar
• Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121:91–100.
   PubMed Web of Science ®Google Scholar
• Byrne CD, Olufadi R, Bruce KD, Cagampang FR, Ahmed MH. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci (Lond) 2009;116:539–64.
   PubMed Web of Science ®Google Scholar
• Jimba S, Nakagami T, Takahashi M, et al. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med 2005;22:1141–5.
   PubMed Web of Science ®Google Scholar
• Adams LA, Lymp JF, St SJ, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129:113–21.
   PubMed Web of Science ®Google Scholar
• Adams LA, Harmsen S, St Sauver JL, et al. Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study. Am J Gastroenterol 2010;105:1567–73.
   PubMed Web of Science ®Google Scholar
• Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118:1388–93.
   PubMed Web of Science ®Google Scholar
• Ahmed MH. Biochemical markers: the road map for the diagnosis of nonalcoholic fatty liver disease. Am J Clin Pathol 2007;127:20–2.
   PubMed Web of Science ®Google Scholar
• Ruhl CE, Everhart JE. Gallstone disease is associated with increased mortality in the United States. Gastroenterology 2011;140:508–16.
   PubMed Web of Science ®Google Scholar
• Mendez-Sanchez N, Bahena-Aponte J, Chavez-Tapia NC, et al. Strong association between gallstones and cardiovascular disease. Am J Gastroenterol 2005;100:827–30.
   PubMed Web of Science ®Google Scholar
• Mendez-Sanchez N, Zamora-Valdes D, Flores-Rangel JA, et al. Gallstones are associated with carotid atherosclerosis. Liver Int 2008;28:402–6.
   PubMed Web of Science ®Google Scholar
• Ahmed MH, Barakat S, Almobarak AO. Nonalcoholic fatty liver disease and cardiovascular disease: has the time come for cardiologists to be hepatologists? J Obes 2012;2012:483135.
   PubMedGoogle Scholar
• Koller T, Kollerova J, Hlavaty T, Huorka M, Payer J. Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors. Scand J Gastroenterol 2012;47:197–203.
   PubMed Web of Science ®Google Scholar
• Ruhl CE, Everhart JE. Relationship of non-alcoholic fatty liver disease with cholecystectomy in the US population. Am J Gastroenterol 2013;108:952–8.
   PubMed Web of Science ®Google Scholar
• Loria P, Lonardo A, Lombardini S, et al. Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors. J Gastroenterol Hepatol 2005;20:1176–84.
   PubMed Web of Science ®Google Scholar
• Fracanzani AL, Valenti L, Russello M, et al. Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease. PLoS One 2012;7:e41183.
   PubMed Web of Science ®Google Scholar
• Yener O, Aksoy F, Demir M, Ozcelik A, Erengul C. Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome. Turk J Gastroenterol 2010;21:411–15.
   PubMed Web of Science ®Google Scholar
• Fraenkel E, Takacs R, Hamvas J, Lengyel G, Feher J. [Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. Orv Hetil 2007;148:793–8.
   PubMedGoogle Scholar
• Lonardo A, Lombardini S, Scaglioni F, et al. Fatty liver, carotid disease and gallstones: a study of age-related associations. World J Gastroenterol 2006;12:5826–33.
   PubMed Web of Science ®Google Scholar
• Ahmed MH, Byrne CD. Current treatment of non-alcoholic fatty liver disease. Diabetes Obes Metab 2009;11:188–95.
   PubMed Web of Science ®Google Scholar
• Bellentani S, Saccoccio G, Masutti F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;132:112–17.
   PubMed Web of Science ®Google Scholar
• Rocha R, Cotrim HP, Carvalho FM, Siqueira AC, Braga H, Freitas LA. Body mass index and waist circumference in non-alcoholic fatty liver disease. J Hum Nutr Diet 2005;18:365–70.
   PubMed Web of Science ®Google Scholar
• Chen LY, Qiao QH, Zhang SC, Chen YH, Chao GQ, Fang LZ. Metabolic syndrome and gallstone disease. World J Gastroenterol 2012;18:4215–20.
   PubMed Web of Science ®Google Scholar
• Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Prospective study of abdominal adiposity and gallstone disease in US men. Am J Clin Nutr 2004;80:38–44.
   PubMed Web of Science ®Google Scholar
• Kim SS, Lee JG, Kim DW, et al. Insulin resistance as a risk factor for gallbladder stone formation in Korean postmenopausal women. Korean J Intern Med 2011;26:285–93.
   PubMedGoogle Scholar
• Shebl FM, Andreotti G, Meyer TE, et al. Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China. Br J Cancer 2011;105:1424–9.
   PubMed Web of Science ®Google Scholar
• Ata N, Kucukazman M, Yavuz B, et al. The metabolic syndrome is associated with complicated gallstone disease. Can J Gastroenterol 2011;25:274–6.
   PubMed Web of Science ®Google Scholar
• Weikert C, Weikert S, Schulze MB, et al. Presence of gallstones or kidney stones and risk of type 2 diabetes. Am J Epidemiol 2010;171:447–54.
   PubMed Web of Science ®Google Scholar
• Kim JM, Lee HL, Moon W, et al. [Association between insulin, insulin resistance, and gallstone disease in Korean general population]. Korean J Gastroenterol 2007;50:183–7.
   PubMedGoogle Scholar
• Nervi F, Miquel JF, Alvarez M, et al. Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. J Hepatol 2006;45:299–305.
   PubMed Web of Science ®Google Scholar
• Chang Y, Sung E, Ryu S, Park YW, Jang YM, Park M. Insulin resistance is associated with gallstones even in non-obese, non-diabetic Korean men. J Korean Med Sci 2008;23:644–50.
   PubMed Web of Science ®Google Scholar
• Nakeeb A, Comuzzie AG, Al-Azzawi H, Sonnenberg GE, Kissebah AH, Pitt HA. Insulin resistance causes human gallbladder dysmotility. J Gastrointest Surg 2006;10:940–8.
   PubMed Web of Science ®Google Scholar
• Biddinger SB, Haas JT, Yu BB, et al. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008;14:778–82.
   PubMed Web of Science ®Google Scholar
• Smelt AH. Triglycerides and gallstone formation. Clin Chim Acta 2010;411:1625–31.
   PubMed Web of Science ®Google Scholar
• Bodmer M, Brauchli YB, Krahenbuhl S, Jick SS, Meier CR. Statin use and risk of gallstone disease followed by cholecystectomy. JAMA 2009;302:2001–7.
   PubMed Web of Science ®Google Scholar
• Ahmed MH, Byrne CD. Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events. Diabetes Obes Metab 2010;12:958–66.
   PubMed Web of Science ®Google Scholar
• Heaton KW. Cholesterol-rich gallstones. Mol Aspects Med 1987;9:89–96.
   PubMed Web of Science ®Google Scholar
• Heaton KW. Review article: epidemiology of gall-bladder disease–role of intestinal transit. Aliment Pharmacol Ther 2000;14:9–13.
   PubMed Web of Science ®Google Scholar
• Ahmed MH, Osman MM, Alokail MS. Statins and breast cancer: a smoking gun or guilt by association? Expert Opin Drug Saf 2006;5:599–601.
   PubMed Web of Science ®Google Scholar
• Brenneman DE, Connor WE, Forker EL, DenBesten L. The formation of abnormal bile and cholesterol gallstones from dietary cholesterol in the prairie dog. J Clin Invest 1972;51:1495–503.
   PubMed Web of Science ®Google Scholar
• Holzbach RT. Animal models of cholesterol gallstone disease. Hepatology 1984;4:191S–8S.
   PubMed Web of Science ®Google Scholar
• Abedin MZ, Narins SC, Park EH, Smith P.R, Kirkwood KS. Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs. Dig Dis Sci 2002;47:2192–210.
   PubMed Web of Science ®Google Scholar
• Saunders KD, Cates JA, Abedin MZ, et al. Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog. Ann Surg 1991;214:149–54.
   PubMed Web of Science ®Google Scholar
• Erichsen R, Froslev T, Lash TL, Pedersen L, Sorensen HT. Long-term statin use and the risk of gallstone disease: a population-based case-control study. Am J Epidemiol 2011;173:162–70.
   PubMed Web of Science ®Google Scholar
• Merzon E, Weiss NS, Lustman AJ, Elhayani A, Dresner J, Vinker S. Statin administration and risk of cholecystectomy: a population-based case-control study. Expert Opin Drug Saf 2010;9:539–43.
   PubMed Web of Science ®Google Scholar
• Caroli-Bosc FX, Le GP, Pugliese P, et al. Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population. Dig Dis Sci 2001;46:540–4.
   PubMed Web of Science ®Google Scholar
• Tazuma S, Kajiyama G, Mizuno T, et al. A combination therapy with simvastatin and ursodeoxycholic acid is more effective for cholesterol gallstone dissolution than is ursodeoxycholic acid monotherapy. J Clin Gastroenterol 1998;26:287–91.
   PubMed Web of Science ®Google Scholar
• Hillebrant CG, Nyberg B, Gustafsson U, et al. Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism. Eur J Clin Invest 2002;32:528–34.
   PubMed Web of Science ®Google Scholar
• Wang HH, Portincasa P, Mendez-Sanchez N, Uribe M, Wang DQ. Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology 2008;134:2101–10.
   PubMed Web of Science ®Google Scholar
• Jonkers IJ, Smelt AH, Ledeboer M, et al. Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil. Gut 2003;52:109–15.
   PubMed Web of Science ®Google Scholar