448
Views
22
CrossRef citations to date
0
Altmetric
Liver and biliary tract

Vitamin B12 and its binding proteins in hepatocellular carcinoma and chronic liver diseases

, , , , , , , , , & show all
Pages 1096-1102 | Received 24 Mar 2014, Accepted 30 Apr 2014, Published online: 24 Jun 2014

References

  • Bosch FX, Ribes J, Cleries R, Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005;9:191–211.
  • Ryder SD. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 2003;52:1111–18.
  • Ermens AA, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 2003;36:585–90.
  • Arendt JF, Quadros EV, Nexo E. Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin - establishment and validation of an ELISA. Clin Chem Lab Med 2011;50:515–19.
  • Nexo E, Olesen H, Norredam K, Schwartz M. A rare case of megaloblastic anaemia caused by disturbances in the plasma cobalamin binding proteins in a patient with hepatocellular carcinoma. Scand J Haematol 1975;14:320–7.
  • Lildballe DL, Nguyen KQ, Poulsen SS, Nielsen HO, Nexo E. Haptocorrin as marker of disease progression in fibrolamellar hepatocellular carcinoma. Eur J Surg Oncol 2011;37:72–9.
  • Kanai T, Takabayashi T, Kawano Y, Kuramochi S, Miyazawa N. A case of postoperative recurrence of fibrolamellar hepatocellular carcinoma with increased vitamin B12 binding capacity in a young Japanese female. Jpn J Clin Oncol 2004;34:346.
  • Boisson F, Fremont S, Migeon C, Nodari F, Droesch S, Gerard P, et al. Human haptocorrin in hepatocellular carcinoma. Cancer Detect Prev 1999;23:89–96.
  • Kane SP, Murray-Lyon IM, Paradinas FJ, Johnson PJ, Williams R, Orr A, et al. Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma. Gut 1978;19:1105–9.
  • Morbak A, Poulsen SS, Nexo E. Haptocorrin in humans. Clin Chem Lab Med 2007;45:1751–9.
  • Burger RL, Schneider RJ, Mehlman CS, Allen RH. Human plasma R-type vitamin B12-binding proteins. II. The role of transcobalamin I, transcobalamin III, and the normal granulocyte vitamin B12-binding protein in the plasma transport of vitamin B12. J Biol Chem 1975;250:7707–13.
  • Osifo BO, Ayoola A, Parmentier Y, Gerard P, Nicolas JP. Correlation between serum enzymes and serum unsaturated vitamin B12 binding proteins in primary liver carcinoma. Enzyme 1988;39:161–6.
  • Fremont S, Champigneulle B, Gerard P, Felden F, Lambert D, Gueant JL, et al. Blood transcobalamin levels in malignant hepatoma. Tumour Biol 1991;12:353–9.
  • Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr 1998;17:235–8.
  • Joske RA. The vitamin B12 content of human liver tissue obtained by aspiration biopsy. Gut 1963;4:231–5.
  • Lambert D, Benhayoun S, Adjalla C, Gelot MM, Renkes P, Gerard P, et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion 1997;58:64–71.
  • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020–2.
  • Rode A, Nicoll A, Moller HJ, Lim L, Angus PW, Kronborg I, et al. Hepatic macrophage activation predicts clinical decompensation in chronic liver disease. Gut 2013;62:1231–2.
  • Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999;19:329–38.
  • Morkbak AL, Pedersen JF, Nexo E. Glycosylation independent measurement of the cobalamin binding protein haptocorrin. Clin Chim Acta 2005;356:184–90.
  • Nexo E, Christensen AL, Petersen TE, Fedosov SN. Measurement of transcobalamin by ELISA. Clin Chem 2000;46:1643–9.
  • Nexo E, Christensen AL, Hvas AM, Petersen TE, Fedosov SN. Quantification of holo-transcobalamin, a marker of vitamin B12 deficiency. Clin Chem 2002;48:561–2.
  • Waxman S, Liu CK, Schreiber C, Helson L. The clinical and physiological implications of hepatoma B12-binding proteins. Cancer Res 1977;37:1908–14.
  • Stibler H, Hultcrantz R. Carbohydrate-deficient transferrin in serum in patients with liver diseases. Alcohol Clin Exp Res 1987;11:468–73.
  • Meregalli M, Giacomini V, Lino S, Marchetti L, DeFeo T, Cappellini MD, et al. Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. Alcohol Clin Exp Res 1995;19:1525–7.
  • Sawamura T, Nakada H, Hazama H, Shiozaki Y, Sameshima Y, Tashiro Y. Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma. Gastroenterology 1984;87:1217–21.
  • Moller HJ, Moestrup SK, Weis N, Wejse C, Nielsen H, Pedersen SS, et al. Macrophage serum markers in pneumococcal bacteremia: prediction of survival by soluble CD163. Crit Care Med 2006;34:2561–6.
  • Hoffmann-Lucke E, Arendt JF, Nissen PH, Mikkelsen G, Aasly JO, Nexo E. Three family members with elevated plasma cobalamin, transcobalamin and soluble transcobalamin receptor (sCD320). Clin Chem Lab Med 2013;51:677–82.
  • Abuyaman O, Andreasen BH, Kronborg C, Vittinghus E, Nexo E. The soluble receptor for vitamin B12 uptake (sCD320) increases during pregnancy and occurs in higher concentration in urine than in serum. PLoS One 2013;8:e73110.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.