Protective Effect of Low Dose of Enprostil against Gastric Blood Loss Induced by Aspirin in Man

References

• Davenport H W. Salicylate damage to the gastric mucosal barrier. N Engl J Med 1967; 276: 1307–1312
   PubMed Web of Science ®Google Scholar
• Lee Y H, Mollison K W, Cheng W D. The effects of antiulcer agents on indomethacin-induced gastric ulceration in the rat. Arch Int Pharmacodyn 1971; 192: 370–377
   PubMedGoogle Scholar
• Muir A, Cossen J A. Aspirin and ulcer. Br Med J 1955; 2: 7–12
   PubMed Web of Science ®Google Scholar
• Pemberton R E, Stand L J. A review of upper gastrointestinal effects of the newer nonsteroids antiinflammatory agents. Dig Dis Sci 1979; 24: 53–64
   PubMed Web of Science ®Google Scholar
• Lanza F L, Royer G L, Nelson R S, Chen T T, Seck-Man C E, Rack M F. The effects of ibuprofen, indo-methacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers. A gastroscopic and photographic study. Dig Dis Sci 1979; 24: 823–828
   PubMed Web of Science ®Google Scholar
• Grossman M I, Matsumoto K K, Lichter R J. Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterology 1961; 40: 383–388
   PubMed Web of Science ®Google Scholar
• Hunt J N, Fisher M A. Aspirin-induced gastric bleeding stops despite rising plasma salicylate. Dig Dis Sci 1980; 25: 135–139
   PubMed Web of Science ®Google Scholar
• Geall M G, Phillips S F, Summerskill W HJ. Profile of gastric potential difference in man. Effects of aspirin, alcohol, bile and endogenous acid. Gastroenterology 1970; 58: 437–44
   PubMed Web of Science ®Google Scholar
• Vane J R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 1971; 231: 232–235
   PubMedGoogle Scholar
• Robert A. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. Adv Prostaglandin Thromboxane Res 1976; 2: 507–520
   PubMedGoogle Scholar
• Cohen M M, Cheung G, Lyster D M. Prevention of aspirin-induced fecal blood loss by PGE2. Gut 1980; 21: 602–606
   PubMed Web of Science ®Google Scholar
• Hunt J N, Franz D R. Effect of prostaglandin E2 on gastric mucosal bleeding caused by aspirin. Dig Dis Sci 1981; 26: 301–305
   PubMed Web of Science ®Google Scholar
• Johansson C, Kollberg B, Nordemar R, Samuelson K, Bergstrom S. Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Gastroenterology 1980; 78: 479–483
   PubMed Web of Science ®Google Scholar
• Thomson A B, Navert H, Halvorsen L, et al. Treatment of duodenal ulcer with enprostil, a synthetic prostaglandin E2 analogue. Am J Med 1986; 81(suppl 2A)59–63
   PubMed Web of Science ®Google Scholar
• Navert H, Thomson A B, Archambault A, et al. Treatment of gastric ulcer with enprostil. Am J Med 1986; 81(suppl 2A)75–79
   PubMed Web of Science ®Google Scholar
• Cohen M M, McReady D R, Clark L, Sevelius H. Protection against aspirin-induced antral duodenal damage with enprostil. A double-blind endoscopic study. Gastroenterology 1985; 88: 382–386
   PubMed Web of Science ®Google Scholar
• Hawkey C J, Simpson G, Sommerville K W. Reduction by enprostil of aspirin-induced blood loss from human gastric mucosa. Am J Med 1986; 81(suppl 2A)50–53
   PubMedGoogle Scholar
• Navert H, Lamothe M, Lebel E, Tetreault L, Had-Dad H. Evaluation of the gastrointestinal cytoprotective effects of enprostil following aspirin administration in man. Gastroenterology 1984; 86: 1194
   Google Scholar
• Hunt J N. A procedure for measuring gastric bleeding caused by drugs. Dig Dis Sci 1979; 24: 525–528
   PubMed Web of Science ®Google Scholar
• Ivey K J, Shedl H P. Gastric non-absorbable indicators for studies in man. Gastroenterology 1979; 59: 234–239
   Google Scholar
• Fisher M A, Hunt J N. A sensitive method for measuring haemoglobin in gastric contents. Digestion 1976; 14: 409–414
   PubMed Web of Science ®Google Scholar
• O'Kruk R J, Adams M A, Philip R B. Rapid and sensitive determination of acetylsalicylic acid and its metabolites using reversed-phase high-performance liquid chromatography. J Chromatogr 1984; 310: 343–352
   PubMed Web of Science ®Google Scholar
• Konturek S J, Kwiecen N, Obtulowicz W, Polanski M, Kopp B, Oleksy J. Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man. Gut 1983; 24: 89–93
   PubMed Web of Science ®Google Scholar
• Stiel D, Ellard K T, Hills L I, Brooks P M. Protective effect of enprostil against aspirin-induced gas-troduodenal mucosa injury in man. Comparison with cimetidine and sucralfate. Am J Med 1986; 81: 54–58
   PubMed Web of Science ®Google Scholar
• Thorsen W B, Jr., Western D, Tanaka Y, Morissey J F. Aspirin injury to the gastric mucosa: gastro-camera observations of the effects of pH. Arch Intern Med 1968; 121: 499–506
   PubMedGoogle Scholar
• Leonards J R, Levy G. Reduction or prevention of aspirin-induced occult gastrointestinal blood loss in man. Clin Pharmacol Ther 1969; 10: 571–575
   PubMed Web of Science ®Google Scholar
• Bowen B K, Krause W J, Ivey K J. Effect of sodium bicarbonate on aspirin-induced damage and potential difference changes in human gastric mucosa. Br Med J 1977; 2: 1052–1055
   PubMedGoogle Scholar
• Florent C, Desaint B, Joubert M, Maurel M, Bernier J J. Effets de l'enprostil sur les modifications de la difference de potentiel transepitheliale gastrique induites par l'aspirine. Gastroenterol Clin Biol 1987; 11: 886–890
   PubMedGoogle Scholar
• Davis G R, Morawski S F, Forddtran J S. Effect of synthetic PGE2 on food stimulated gastric acid secretion. Clin Pharmacol Therap 1982; 31: 215
   Google Scholar
• Miller T A. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983; 245: G601–623
   PubMed Web of Science ®Google Scholar