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Scandinavian Journal of Gastroenterology Volume 24, 1989 - Issue sup162
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Original Article

Augmentation of the Gastric Mucosal Defense Mechanism Induced by KW-5805, a Novel Antiulcer Agent

H. Tanaka Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
,
N. Kosaka Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
,
A. Tomaru Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
,
K. Shuto Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
,
T. Ogihara Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
&
N. Sato Pharm. Res. Lab., Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan; First Dept. of Medicine, Osaka University Medical School, Osaka, Japan
Pages 170-173 | Published online: 08 Jul 2009

References

  • Kumazawa T., Harakawa H., Obase H., Oiji Y., Tanaka H., Shuto K., Ishii A., Oka T., Nakamizo N. Synthesis and antiulcer activity of 5, 11-Dihydro[1]benzoxepino[3,4-b] pyridines. J Med Chem 1988; 31: 779–785
  • Tanaka H., Kosaka N., Tomaru A., Shuto K. Effect of KW-5805, a novel anti-ulcer agent, on the gastric mucosa. J Pharmac Sci 1987; 76: S320
  • Tanaka H., Kosaka N., Shuto K., Oka T., Nakamizo N. Effect of KW-5805, a new antiulcer agent, on ulcers and gastric secretion in rats. Jpn J Pharmacol 1987; 43(suppl)233
  • Kitagawa H., Takeda F., Kohei H. A simple method of estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneim Forsch 1986; 36: 1240–1244
  • Azumi Y., Ohara S., Ishihara K., Okabe H., Hotta K. Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 1980; 21: 533–536
  • Sato N., Kamada T., Shichiri M., Kawano S., Abe H., Hagihara B. Measurement of hemoperfusion and oxygen sufficiency in gastric mucosa in vivo. Gastroenterology 1979; 79: 814–819

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