Helicobacter pylori Infection Is Associated with Low Antral Somatostatin Content in Young Adults Implications for the Pathogenesis of Hypergastrinemia

References

• Levi S., Beardshall K., Haddard G., Playford R., Ghosh P., Calam J. Campylobacter pyloriand duodenal ulcers: the gastrin link. Lancet 1989; 1: 1167–8
   PubMed Web of Science ®Google Scholar
• Graham D. Y., Opekun A., Lew G. M., Evans DJ, Jr, Klein P. D., Evans D. G. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance ofHelicobacter (Campylobacter) pyloriinfection. Am J Gastroenterol 1990; 85: 394–8
   PubMed Web of Science ®Google Scholar
• Smith JCL, Pounder R. E., Nwokolo C. U., Lanzon-Miller S, Evans D. G., Graham D. Y., et al. Inappropriate hypergastrinemia in asymptomatic healthy subjects infected withHelicobacter pylori. Gut 1990; 31: 522–5
   PubMed Web of Science ®Google Scholar
• Graham D. Y., Opekun A., Lew G. M., Klein P., Walsh J. H. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology 1991; 100: 1571–5
   PubMed Web of Science ®Google Scholar
• Levi S., Beardshall K., Sewift I., Foulkes W., Playford R., Ghosh P., et al. AntralHelicobacter pylori, hypergastrinemia, and duodenal ulcers: effect of eradicating the organism. Br Med J 1989; 1504–5
   PubMedGoogle Scholar
• Oderda G., Vaira D., Holton J., Ainley C., Altare F., Ansaldi N. Amoxycillin plus tinidasole forCampylobacter pylorigastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. Lancet 1989; 1: 690–2
   PubMed Web of Science ®Google Scholar
• Chittajallu R. S., Dorrian C. A., Ardill JES, McColl KEL. Effect ofHelicobacter pylorion serum pepsinogen I and plasma gastrin in duodenal ulcer patients. Scand J Gastroenterol 1992; 27: 20–4
   PubMed Web of Science ®Google Scholar
• Moss S. F., Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication ofHelicobacter pylori. Gut 1993; 34: 888–92
   PubMed Web of Science ®Google Scholar
• El-Omar E, Penman I, Dorrian C. A., Ardill JES, McColl KEL. EradicatingHelicobacter pyloriinfection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut 1993; 34: 1060–5
   PubMed Web of Science ®Google Scholar
• Wagner S., Haruma K., Gladziwa U., Soudah B., Gebel M., Bleck J., et al. Helicobacter pyloriinfection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication. Am J Gastroenterol 1994; 89: 1515–9
   PubMed Web of Science ®Google Scholar
• Sumii K., Yokoyama Y., Matsui Y., Kikkawa N., Hidaka T., Suenaga K., et al. The increased antral gastrin content and its release in response to test meal in patients with duodenal ulcer. Hiroshima J Med Sci 1979; 28: 221–7
   PubMed Web of Science ®Google Scholar
• Sumii K., Fukushima T., Hirata K., Matsumoto Y., Sanuki E., Tsumaru S., et al. Antral gastrin and somatostatin concentrations in peptic ulcer patients. Peptides 1981; 2(Suppl 2)281–3
   PubMedGoogle Scholar
• Saffouri B., Weir G., Bitar K., Mahklouf G. Stimulation of gastrin secretion from perfused rat stomach by somatostatin antiserum. Life Sci 1979; 25: 1749–54
   PubMed Web of Science ®Google Scholar
• Schusdziarra V., Zyznar E., Rouiller D., Boden G., Brown J. C., Arimura A., et al. Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis. Science 1980; 207: 530–2
   PubMed Web of Science ®Google Scholar
• Larsson L. I., Goltermann N., Magistris L., Rehfeld J. F., Schwartz T. W. Somatostatin cell processes as pathways for paracrine secretion. Science 1979; 205: 1393–5
   PubMed Web of Science ®Google Scholar
• Kaneko H., Nakada K., Mitsuma T., Uchida K., Kotera H., Furusawa A., et al. Helicobacter pyloriinfection induces decrease in immunoreactive-somatostatin concentrations of human stomach. Dig Dis Sci 1992; 37: 409–16
   PubMed Web of Science ®Google Scholar
• Queiroz DMM, Mendes E. N., Rocha G. A., Moura S. B., Resende LMH, Barbosa AJA, et al. Effect ofHelicobacter pylorieradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations. Scand J Gastroenterol 1993; 28: 858–64
   PubMed Web of Science ®Google Scholar
• Moss S., Legon S., Bishop A., Polak J. M., Calam J. Effect ofHelicobacter pylorion gastric somatostatin in duodenal ulcer disease. Lancet 1992; 930–2
   PubMedGoogle Scholar
• Chayvialle JAP, Descos F, Bernard C, Martin A, Barbe C, Partensky C. Somatostatin in mucosa of stomach and duodenum in gastroduodenal disease. Gastroenterology 1978; 75: 13–9
   PubMed Web of Science ®Google Scholar
• Harty R. F., Maico D. G., McGuigan J. E. Antral release of gastrin and somatostatin in duodenal ulcer and control subjects. Gut 1986; 27: 652–8
   PubMed Web of Science ®Google Scholar
• Murthy U. K., Linscheer R., Cho C. The hypergastrinemia inHelicobacter pylori(HP)-gastritis is due to a decrease in antral D cell density and D:G cell ratio. Gastroenterology 1992; 102: A130
   Google Scholar
• Haruma K., Kawaguchi H., Yoshihara M., Okamoto S., Shimamoto T., Fujimura J., et al. Effect ofHelicobacter pylorion the status of the antral G and D cells in subjects wit gastritis and normal mucosa. Gastroenterology 1993; 104: A96
   Google Scholar
• Graham D. Y., Lew G. M., Lechago J. Antral G-cell and D-cell numbers inHelicobacter pyloriinfection: effect ofH. pylorieradication. Gastroenterology 1993; 104: 1655–60
   PubMed Web of Science ®Google Scholar
• Trudeau W., McGuigan J. E. Serum gastrin levels in patients with peptic ulcer disease. Gastroenterology 1963; 45: 14–26
   PubMedGoogle Scholar
• Tahir H., Sumii K., Haruma K., Tari A., Uemura N., Shimizu H., et al. A statistical evaluation on the age and sex distribution of basal serum gastrin and gastric acid secretion in subjects with or without peptic ulcer disease. Hiroshima J Med Sci 1984; 33: 125–30
   PubMed Web of Science ®Google Scholar
• Westerveld B. D., Pals G., Lamers CBHW, Defize J, Pronk J. C., Frants R. R., et al. Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels. Cancer 1987; 59: 952–8
   PubMed Web of Science ®Google Scholar
• Sipponen P., Valle J., Varis K., Kekki M., Ihamaki T., Siurala M. Fasting levels of serum gastrin in different functional and morphologic states of the antrofundal mucosa. Scand J Gastroenterol 1990; 25: 513–9
   PubMed Web of Science ®Google Scholar