References
- Sharon P, Stenson W F. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 1984; 86: 453–60
- Boughton-Smith N K, Hawkey C J, Whittle B JR. Biosynthesis of lipoxygenase and cyclo-oxygenase products from 14C arachidonic acid by human colonic mucosa. Gut 1983; 24: 1176–82
- Stenson W F. Arachidonic acid metabolites in inflammatory bowel disease. Adv Inflamm Res 1988; 12: 215–22
- Schumbert R, Towner J, Zipser R D. Role of eicosanoids in human and experimental colitis. Dig Dis Sci 1988; 33: 585–645
- Goetzl E J, Burrall B, Baud L, et al. Generation and recognition of leukotriene mediators of hypersensitivity and inflammation. Dig Dis Sci 1988; 33: 36S–40S
- Greaves M W, Camp R DR. Prostaglandins, leukotrienes, phospholipase, platelet activating factor, and cytokines. An integrated approach to inflammation of human skin. Arch Dermatol Res 1988; 280: S33–41
- Fry L. Psoriasis. Br J Dermatol 1988; 119: 445–61
- Belch J JF. Eicosanoids and rheumatology. Inflammatory and vascular aspects. Prostaglandins Leukotr Essent Fatty Acids 1989; 36: 219–34
- Mayer M. Effect of calcium ionophore A23187 and of leukotriene B4 and C4 on the adherence of mononuclear leukocytes in multiple sclerosis. Folia Biol (Praha) 1988; 34: 10–7
- Ford-Hutchinson A W, Bray M A, Doig M V. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980; 286: 264–5
- Smith M J, Ford-Hutchinson A W, Bray M A. Leukotriene B: a potential mediator of inflammation. J Pharm Pharmacol 1980; 32: 517–8
- Bokoch G M, Reed P W. Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes. J Biol Chem 1981; 256: 5317–20
- Sumimoto H, Takeshige K, Minakami S. Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4. Biochim Biophys Acta 1984; 803: 271–7
- Yamamoto S, Ueda N, Ehara H. Biochemical studies on mammalian lipoxygenases. Ann NY Acad Sci 1988; 524: 12–26
- MacDermott R P, Stenson W F. Alterations of the immune system in ulcerative colitis and Crohn's disease. Adv Immunol 1988; 42: 285–328
- Lauritsen K, Laursen L S, Bukhave K, et al. Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 1986; 91: 837–44
- Gould S R, Brash A R, Conolly M E, et al. Studies of prostaglandins and sulphasalazine in ulcerative colitis. Prostaglandins Med 1981; 6: 165–82
- Powell W S. Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes. J Biol Chem 1984; 259: 3082–9
- Shak S, Goldstein I M. Leukotriene B4 ω-hydroxylase in human polymorphonuclear leukocytes—partial purification and identification as a cytochrome P-450. J Clin Invest 1985; 76: 1218–28
- Ford-Hutchinson A W, Rackham A, Rokach J, et al. Comparative biological activities of synthetic leukotriene B4 and its ω-oxidation products. Prostaglandins 1983; 25: 24–37
- Sumimoto H, Takeshige K, Sakai H, et al. A cell-free preparation of human neutrophils catalyzing NADPH-dependent conversion of leukotriene B4. Biochem Biophys Res Commun 1984; 125: 615–21
- Ogorek C P, Caroline D F, Fisher R S. Presentation, evaluation, and natural history of inflammatory bowel disease. Curr Top Gastroenterol. Inflammatory bowel disease. 1992; 1: 355–86
- Kozarek R A. Endoscopy in inflammatory bowel disease. Curr Top Gastroenterol. Inflammatory bowel disease. 1992; 1: 439–52
- Rubesin S E, Laufer I, Dinsmore B. Radiologic investigation of inflammatory bowel disease. Curr Top Gastroenterol. Inflammatory bowel disease. 1992; 1: 453–92
- Owen D A. Pathology of inflammatory bowel disease. Curr Top Gastroenterol. Inflammatory bowel disease. 1992; 1: 355–86
- Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–54
- Ikehata A, Hiwatashi N, Kinouchi Y, et al. Leukotriene B4 ω-hydroxylase activity in polymorphonuclear leukocytes from patients with inflammatory bowel disease. Prostaglandins Leukotr Essent Fatty Acids 1993; 49: 489–94
- Lauritsen K, Laursen L S, Bukhave K, et al. In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis. Gastroenterology 1988; 95: 11–7
- Middleton S J, Shorthouse M, Hunter J O. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993; 341: 465–6
- Middleton S J, Hunter J O. Colonic circular smooth muscle relaxation by leucocyte derived nitric oxide. Gut 1991; 32: A1248
- Boughton-Smith N K, Evans S M, Cole A T, et al. Induction of nitric oxide synthase in inflamed colon from ulcerative colitis patients. Gastroenterology 1993; 104: A673
- Wink D A, Osawa Y, Darbyshire J F, et al. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch Biochem Biophys 1993; 300: 115–23
- Needleman P, Turk J, Jakschik B A, et al. Arachidonic acid metabolism. Annu Rev Biochem 1986; 55: 69–102
- White A, Handler P, Smith E L, et al. Principle of biochemistry6th ed. McGraw-Hill Kogakusha Ltd, Tokyo 1987
- Rojas M, Camus A M, Alexandrov K, et al. Stereoselective metabolism of (—)-benzol[a]pyrene-7,8-diol by human lung microsomes and peripheral blood lymphocytes: effect of smoking. Carcinogenesis 1992; 13: 929–33
- Gonzalez F J, Skoda R C, Kimura S, et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 1988; 331: 442–6
- Baer A N, McAllister C B, Wilinson G R, et al. Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus. Arthritis Rheum 1986; 29: 843–50