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Original Article

Protection against Acetaminophen-Induced Liver Injury in Vivo by an Iron Chelator, Deferoxamine

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Pages 61-67 | Received 10 Jan 1994, Accepted 25 Apr 1994, Published online: 08 Jul 2009

References

  • Davidson D GD, Eastham W N. Acute liver necrosis following overdosage of paracetamol. Br Med J 1966; 2: 497–9
  • Proudfoot A T, Wright N. Acute paracetamol poisoning. Br Med J 1970; 3: 557–8
  • Mitchell J R, Jollow D J, Potter W Z, Davis D C, Gillette J R, Brodie B B. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 1973; 187: 185–94
  • Rumack B H, Peterson R C, Koch G G. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981; 141: 380–5
  • Harrison P M, Wendon J A, Gimson A ES, Alexander G JM, Williams R. Improvement by acetylcystein of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991; 324: 1852–7
  • Harrison P M, Keays R, Bray G P, Alexander G JM, Williams R. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcystein. Lancet 1990; 335: 1572–3
  • Jollow D J, Mitchell J R, Potter W Z, David D C, Gillette J R, Brodie B B. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187: 195–202
  • Potter W Z, Davis D C, Mitchell J R, Jollow D J, Gillete J R, Brodie B B. Acetaminophen-induced hepatic necrosis. III. Cytochrome p-450-mediated covalent binding in vitro. J Pharmacol Exp Ther 1973; 187: 203–10
  • Potter W Z, Thorgeirsson S S, Jollow D J, Mitchell J R. Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology 1973; 12: 129–43
  • Jollow D J, Thorgeirsson S S, Potter W Z, Hashimoto M, Mitchell J R. Acetaminophen-induced hepatic necrosis. VI. Metabolic disruption of toxic and non-toxic doses of acetaminophen. Pharmacology 1979; 12: 251–71
  • Wendel A, Feuerstein S, Konz K H. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol 1979; 28: 2051–5
  • Wendel A, Feuerstein S. Drug-induced lipid peroxidation in mice. I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem Pharmacol 1981; 30: 2513–20
  • Wendel A, Jaeschke H, Gloger M. Drug-induced lipid peroxidation. II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione. Biochem Pharmacol 1982; 31: 3601–5
  • Farber J L, Leonard T B, Kyle M E, Nakae D, Serroni A, Rogers S A. Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes. Arch Biochem Biophys 1988; 267: 640–50
  • Kyle M E, Miccadei S, Nakae D, Farber J L. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun 1987; 149: 889–96
  • Kyle M E, Sakaida I, Serroni A, Farber J L. Metabolism of acetaminophen by cultured rat hepatocytes. Biochem Pharmacol 1990; 40: 1211–8
  • Sakaida I, Kyle M E, Farber J L. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Molec Pharmacol 1990; 37: 435–42
  • Sakaida I, Thomas A P, Farber J L. Increase in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. J Biol Chem 1991; 266: 717–22
  • Laub R Y-J, Schneider J-N, Octave A, Trouet A C, Crichton R R. Cellular pharmacology of deferoxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization. Biochem Pharmacol 1985; 34: 1175–83
  • Kyle M E, Nakae D, Sakaida I, Serroni A, Farber J L. Protein thiol depletion and the killing of cultured hepatocytes by hydrogen peroxide. Biochem Pharmacol 1989; 38: 3797–805
  • Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976; 15: 212–6
  • Reed D J, Babson J R, Beatty P W, Brodie A E, Ellis W W, Potter D W. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Ann Biochem 1980; 106: 55–62
  • Lowry O H, Rosenbrough N J, Farr A L, Randall R J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–75

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