9
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Prognostic Significance of p53 Expression, Chromosome 17 Copy Number, and DNA Ploidy in Non-Metastasized Colorectal Carcinomas (Stages IB and II)

, , , , , & show all
Pages 481-489 | Received 03 Aug 1995, Accepted 12 Oct 1995, Published online: 08 Jul 2009

References

  • Thomas R M, Sobin L H. Gastrointestinal cancer. Cancer 1995; 75(Suppl)154–70
  • Statistisches Bundesamt. Statistisches Jahrbuch 1993 für die Bundesrepublik Deutschland (German Federal Office for Statistics. Statistical yearbook 1993 for the Federal Republic of Germany). Statistisches Bundesamt, Wiesbaden 1993
  • Moertel C G, Fleming T R, MacDonald J S, Haller D G, Laurie J A, Goodman M S, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322: 352–8
  • Krook J E, Moertel C G, Gunderson L L, Wieand H S, Collins R T, Beart R W, et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991; 324: 709–15
  • Wood D A, Robbins G F, Zippin C, Lum D, Stearns M. Staging of cancer of the colon and the rectum. Cancer 1979; 43: 961–8
  • UICC. International Union Against Cancer. TNM-atlas: illustrated guide to the TNM/pTNM-classification of malignant tumors. Springer, New York 1993
  • Baker S J, Fearon E R, Nigro J M, Hamilton S R, Preisinger A C, Jessup J M, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989; 244: 217–21
  • Fearon E R, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759–67
  • Remvikos Y, Tominaga O, Hammel P, Laurent Puig P, Salmon R J, Dutrillaux B, et al. Increased p53 protein content of colorectal tumours correlates with poor survival. Br J Cancer 1992; 66: 758–64
  • Starzynska T, Bromery M. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer 1992; 66: 558–62
  • Hopman A H, van Hooren E, van de Kaa C A, Vooijs P G, Ramaekers F C. Detection of numerical chromosome aberrations using in situ hybridization in paraffin sections of routinely processed bladder cancers. Mod Pathol 1991; 4: 503–13
  • Lane D P. p53, guardian of the genome. Nature 1992; 358: 15–6
  • Vogelstein B, Kinzler K W. p53 function and dysfunction. Cell 1992; 70: 523–6
  • Jass J R, Sobin L H. Histological typing of intestinal tumours. World Health Organization. International Classification of Tumours. Springer, Berlin 1989
  • Cordell J L, Falini B, Erber W N, Ghosh A K, Abdulaziz Z, McDonald S, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984; 32: 219–29
  • Baretton G B, Valina C, Vogt T, Schneiderbanger K, Diebold J, Löhrs U. Interphase cytogenetic analysis of prostatic carcinomas by use of nonisotopic in situ hybridization. Cancer Res 1994; 54: 4472–80
  • Hopman A NH, Ramaekers F CS, Vooijs G P. Interphase cytogenetics of solid tumours. In situ hybridization: principles and practice, J M Polak, J O McGee. Oxford University Press, Oxford 1989; 165–86
  • Stock C, Ambros I M, Mann G, Gadner H, Amann G, Ambros P F. Detection of 1p36 deletions in paraffin sections of neuroblastoma tissues. Genes Chromosom Cancer 1993; 6: 1–9
  • Baretton G, Müller M, Schneiderbanger K, Wirtz A, Wisser J, Arnholdt H, et al. Cytogenetic aberrations in abortions: correlation of conventional karyotyping and interphase cytogenetics on tissue sections and nuclear suspensions. Path Res Pract 1995; 191: 206, 98
  • Hedley D W, Friedlander M L, Taylor I W, Rugg C A, Musgrove E A. Method for analysis of cellular DNA-content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333–5
  • Baretton G, Gille J, Oevermann E, Löhrs U. Flow-cytometric analysis of the DNA-content in paraffin-embedded tissue from colorectal carcinomas and its prognostic significance. Virchows Arch [Cell Pathol] 1991; 60: 123–31
  • van den Berg F M, Tigges A J, Schipper M EI, Den Hartog-Jager F CA, Kroes W GM, Walboomers J MM. Expression of the nuclear oncogene p53 in colon tumours. J Pathol 1989; 157: 193–9
  • Campo E, de la Calle-Martin O, Miquel R, Palacin A, Romero M, Fabregat V, et al. Loss of heterozygosity of p53 gene and p53 gene product in human colorectal carcinomas. Cancer Res 1991; 51: 4436–42
  • Purdie C A, O'Gradie J, Piris J, Wyllie A H, Bird C C. P53 expression in colorectal tumors. Am J Pathol 1991; 138: 807–13
  • Kawasaki Y, Monden T, Morimoto H, Murotani M, Miyoshi Y, Kobayshi T, et al. Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma. Am J Clin Pathol 1992; 97: 244–9
  • Wynford-Thomas D. p53 in tumour pathology: can we trust immunohistochemistry. J Pathol 1992; 166: 329–30
  • Battifora H. p53 immunohistochemistry: a word of caution. Hum Pathol 1994; 25: 435–7
  • Baas I, Mulder J-W R, Offerhaus J A, Vogelstein B, Hamilton S R. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J Pathol 1994; 172: 5–12
  • Hollstein M, Sidransky D, Vogelstein B, Harris C C. p53 mutations in human cancers. Science 1991; 253: 49–53
  • Hamelin R, Laurent Puig P, Olschwang S, Jego N, Asselain B, Remvikos Y, et al. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 1994; 106: 42–8
  • Steiner M G, Harlow S P, Colombo E, Bauer K D. Chromosomes 8, 12, and 17 copy number in Astler-Coller stage C colon cancer in relation to proliferative activity and DNA ploidy. Cancer Res 1993; 53: 681–6
  • Offerhaus G JA, De Feyter E P, Cornelisse C J, Tersmette K WF, Floyd J, Kern S E, et al. The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma. Gastroenterology 1992; 102: 1612–9
  • Meling G I, Lothe R A, Borresen A L, Graue C, Hauge S, Clausen O P, et al. The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinico-pathological variables. Br J Cancer 1993; 67: 93–8
  • Laurent Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T, et al. Survival and acquired genetic alterations in colorectal cancer. Gastroenterology 1992; 102: 1136–41
  • Brodeur G M. The NF1 gene in myelopoiesis and childhood myelodysplastic syndromes. N Engl J Med 1994; 330: 637–8
  • Hall J M, Lee M K, Newman B. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990; 250: 1684–9
  • Makos Wales M, Biel M A, El Deiry W, Nelkin B D, Issa J P, Cavanee W K, et al. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nature [Med] 1995; 1: 570–7
  • Galandiuk S, Miseljic S, Yang A R, Early M, McCoy M D, Wittliff J L. Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. Arch Surg 1993; 128: 637–42
  • Armitage N C, Robins R A, Evans D F, Turner D R, Baldwin R W, Hardcastle J D. The influence of tumor cell DNA abnormalities on survival in colorectal cancer. Br J Surg 1985; 72: 828–30
  • Armitage N C, Ballantyne K C, Evans D F, Clarke P, Sheffield J, Hardcastle J D. The influence of tumour cell DNA content on survival in colorectal cancer: a detailed analysis. Br J Cancer 1990; 62: 852–6
  • Goh H S, Jass J R, Atkin W S, Cuzick J, Northover J MA. Value of flow cytometric determination of ploidy as a guide to prognosis in operable rectal cancer: a multivariable analysis. Int J Colorect Dis 1987; 2: 17–21
  • Witzig T E, Loprinzi C L, Gonchoroff N J, Reimann H M, Cha S S, Wieand H S, et al. DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma. Cancer 1991; 68: 879–88
  • De Angelis P, Stokke T, Smedshammer L, Lothe R A, Meling G I, Rofstad M, et al. p53 expression is associated with a high degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas. Int J Oncol 1993; 3: 305–12
  • El-Naggar A K, van Dekken H D, Ensign L G, Pathak S. Interphase cytogenetics in paraffin-embedded sections from renal cortical neoplasms. Correlation with cytogenetic and flow cytometric DNA ploidy analyses. Cancer Genet Cytogenet 1994; 73: 134–41
  • Peltomaki P, Lothe R A, Aaltonen L A, Pylkkanen L, Nystrom Lehti M, Seruca R, et al. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 1993; 53: 5853–5
  • Ionov Y, Peinado M A, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363: 558–61
  • Thibodeau S N, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816–9
  • Lothe R A, Peltomaki P, Meling G I, Aaltonen L A, Nystrom Lahti M, Pylkkanen L, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993; 53: 5849–52
  • Leach F S, Nicolaides N C, Papadopoulos N, Liu B, Jen J, Parsons R, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75: 1215–25

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.