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Rapid Communication

A bi-functional hepatitis B virus core antigen (HBcAg) chimera activates HBcAg-specific T cells and preS1-specific antibodies

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Pages 55-59 | Received 18 Feb 2011, Accepted 20 Jul 2011, Published online: 21 Sep 2011

References

  • Yang JD, Roberts LR. Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 2010;7:448–58.
  • Beck J, Nassal M. Hepatitis B virus replication. World J Gastroenterol 2007;13:48–64.
  • Milich DR, McLachlan A. The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science 1986;234:1398–401.
  • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005;5:215–29.
  • Billaud JN, Peterson D, Barr M, Chen A, Sallberg M, Garduno F, . Combinatorial approach to hepadnavirus-like particle vaccine design. J Virol 2005;79:13656–66.
  • Lazdina U, Alheim M, Nystrom J, Hultgren C, Borisova G, Sominskaya I, . Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent. J Gen Virol 2003;84(Pt 1):139–46.
  • Lazdina U, Cao T, Steinbergs J, Alheim M, Pumpens P, Peterson DL, . Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells. J Virol 2001;75:6367–74.
  • Milich DR, Chen M, Schodel F, Peterson DL, Jones JE, Hughes JL. Role of B cells in antigen presentation of the hepatitis B core. Proc Natl Acad Sci USA 1997;94: 14648–53.
  • Soderholm J, Ahlen G, Kaul A, Frelin L, Alheim M, Barnfield C, . Relation between viral fitness and immune escape within the hepatitis C virus protease. Gut 2006;55: 266–74.
  • Ahlen G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, . Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes. Gut 2009;58: 560–9.
  • Ahlen G, Nystrom J, Pult I, Frelin L, Hultgren C, Sallberg M. In vivo clearance of hepatitis C virus nonstructural 3/4a-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes. J Infect Dis 2005;192:2112–6.
  • Nystrom J, Chen A, Frelin L, Ahlen G, Koh S, Brass A, . Improving on the ability of endogenous hepatitis B core antigen to prime cytotoxic T lymphocytes. J Infect Dis 2010;201:1867–79.
  • Milich DR, McLachlan A, Moriarty A, Thornton GB. A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg. J Immunol 1987;138:4457–65.
  • Woo G, Tomlinson G, Nishikawa Y, Kowgier M, Sherman M, Wong DK, . Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses. Gastroenterology 2010; 139:1218–29.
  • Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006;1:23–61.
  • Lee BO, Tucker A, Frelin L, Sallberg M, Jones J, Peters C, . Interaction of the hepatitis B core antigen and the innate immune system. J Immunol 2009;182:6670–81.

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