Assessment of 30-day all-cause mortality in metronidazole-treated patients with Clostridium difficile infection

References

• Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353: 2442–9.
   PubMed Web of Science ®Google Scholar
• Pepin J, Valiquette L, Alary ME, Villemure P, Pelletier A, Forget K, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004;171:466–72.
   PubMed Web of Science ®Google Scholar
• Fujitani S, George WL, Murthy AR. Comparison of clinical severity score indices for Clostridium difficile infection. Infect Control Hosp Epidemiol 2011;32:220–8.
   PubMed Web of Science ®Google Scholar
• Belmares J, Gerding DN, Parada JP, Miskevics S, Weaver F, Johnson S. Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system. J Infect 2007;55:495–501.
   PubMed Web of Science ®Google Scholar
• Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007;45:302–7.
   PubMed Web of Science ®Google Scholar
• Velazquez-Gomez I, Rocha-Rodriguez R, Toro DH, Gutierrez-Nunez JJ, Gonzalez G, Saavedra S. A severity score index for Clostridium difficile infection. Infect Dis Clin Pract 2008;16:376–8.
   Google Scholar
• Lungulescu OA, Cao W, Gatskevich E, Tlhabano L, Stratidis JG. CSI: a severity index for Clostridium difficile infection at the time of admission. J Hosp Infect 2011;79:151–4.
   PubMedGoogle Scholar
• Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431–55.
   PubMed Web of Science ®Google Scholar
• Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40:373–83.
   PubMedGoogle Scholar
• Louie, T, Gerson, M, Grimmard, D, Johnson S, Poirier A, Weiss K, et al. Results of a phase III trial comparing tolevamer, vancomycin, and metronidazole in patients with Clostridium difficile-associated diarrhea (CDAD). Program and Abstracts of the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Chicago, IL: September 17–20, 2007; Abstract K-425a.
   Google Scholar
• McGowan AP, Lalayiannis LC, Sarma JB, Marshall B, Martin KE, Welfare MR. Thirty-day mortality of Clostridium difficile infection in a UK National Health Service Foundation Trust between 2002 and 2008. J Hosp Infect 2010; 77:11–5.
   PubMedGoogle Scholar
• Hota SS, Achonu C, Crowcroft NS, Harvey BJ, Lauwers A, Gardam MA. Determining mortality rates attributable to Clostridium difficile infection. Emerg Infect Dis 2012; 18:305–7.
   PubMedGoogle Scholar
• Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, et al. Analysis of 30-day mortality for Clostridium difficile-associated disease in the ICU setting. Chest 2007;132:418–24.
   PubMed Web of Science ®Google Scholar
• Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep 1995;44:1–13.
   Google Scholar
• Al-Nassir WN, Sethi AK, Li Y, Pultz MJ, Riggs MM, Donskey CJ. Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile- associated disease. Antimicrob Agents Chemother 2008;52: 2403–6.
   PubMed Web of Science ®Google Scholar
• Miller M, Bernard L, Thompson M, Grima D, Pepin J. Lack of increased colonization with vancomycin-resistant enterococci during preferential use of vancomycin for treatment during an outbreak of healthcare-associated Clostridium difficile infection. Infect Control Hosp Epidemiol 2010;31:710–5.
   PubMed Web of Science ®Google Scholar