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Scandinavian Journal of Urology and Nephrology Volume 21, 1987 - Issue 4
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Original Article

Ketoconazole High Dose in the Hormonal Treatment of Advanced Carcinoma of the Prostate

A Pilot Study

Svein Hassellund Department of Surgery and Urology and Hormonal Laboratory, Aker Hospital, Oslo, Norway
,
Nils Norman Department of Surgery and Urology and Hormonal Laboratory, Aker Hospital, Oslo, Norway
&
Sten Sander Department of Surgery and Urology and Hormonal Laboratory, Aker Hospital, Oslo, Norway
Pages 273-276 | Received 17 May 1986, Published online: 15 Feb 2010

REFERENCES

  • Amery WK, Trachtenberg J. High dose Ketoconazole, a promising alternative in the hormonal treatment of advanced prostatic cancer. A pilot study. Clinical Research Report, November 1984.
  • Ang KK, Drochmans A, Vantongelen K, van der Schueren E. Feasibility of high-dose Ketoconazole for the management of advanced prostatic cancer. J Urol (in press).
  • Denis L, Chaban M, Mahler CH. Clinical application of Ketoconazole in prostatic cancer. EORTC Genitourinary Group Monograph 2, part 9, 1985: 319–326.
  • Williams G. Ketoconazole for prostate cancer. The Lancet 1986, 696.
  • Heyns W, Drochmans A, van der Schueren E, Verhoeven G. Endocrine effects of high-dose Ketoconazole in advanced prostatic cancer. Acta Endocrinologica 1985; 110: 276–283.
  • Huggins C, Hodges CW. Studies on prostatic cancer. Cancer Research 1941; 293–297.
  • Leuprolide Study Group: Leuprolide versus diethylstilbestrol for metastatic prostate cancer. N Engl J Med 1984; 311: 1281–1286.
  • Loose DS, Stover P, Feldman D. Ketoconazole binds to glucocorticoid receptors and exhibits glucocorticoid antagonist activity in cultured cells. J Clin Invest 1983; 72: 404–408.
  • Nicole P, Pontin A, Sarembock L. High-dose Ketoconazole therapy in prostatic cancer. A pilot study. S Afr Med J 1985; 888–889.
  • Pillans PI, Coheen P, Whitelaw P. Hyponatraemia and confusion in a patient taking Ketoconazole. Lancet 1985; 821–822.
  • Pont A, Goldman E, Sugar AM, Siiteri P, Stevens DA. Ketoconazole induced increase in estradiol-testosterone ratio. Arch Intern Med 1985; 145: 1429–1431.
  • Stevens DA. Ketoconazole metamorphosis. An antimicrobial becomes an endocrine drug. Arch Intern Med 1985; 145: 813–815.
  • Trachtenberg J, Pont A. Ketoconazole therapy for advanced prostate cancer. Lancet 1984; 433–435.
  • Trachtenberg J. Ketoconazole therapy in advanced prostatic cancer. J Urol 1984; 132: 61–63.
  • Ware H, Smith CB, Yeo T, Allan J, Bloom SR, Williams G. Combined Ketoconazole and LHRH producing objective responses in patients with prostatic cancer who had failed conventional treatment. J Steroid Biochem 1981; 20: 1395.
  • White MC, Kendali-Taylor P. Adrenal hypofunction in patients taking Ketoconazole. Lancet 1985; 44–45.

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