Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 2
8
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Relationship between translobular migration in perfused rat liver and hydrophobicity of dialkyl dithiolanylidenemalonates and related compounds

, , &
Pages 241-249 | Received 03 Feb 1986, Published online: 30 Sep 2009

References

  • Bradford W. L., Nakatsugawa T. Perfusion analysis of periportal and centrilobular metabolism of paraoxon in the rat liver. Pesticide Biochemistry and Physiology 1982; 18: 298–303
  • Campra J. L., Reynolds T. B. The hepatic circulation. The Liver: Biology and Pathobiology, I. Arias, H. Popper, D. Schachter, D. A. Shafritz. Raven Press, New York 1982; 627–645
  • Chiou C. T., Freed V. H., Schmedding D. W., Kohnert R. L. Partition coefficient and bioaccumulation of selected organic chemicals. Environmental Science and Technology 1977; 11: 475–478
  • Cignoli E. V., Castro J. A. Lipid peroxidation, necrosis and the in vivo depression of liver glucose 6-phosphatase by carbon tetrachloride. Experimental and Molecular Pathology 1971; 14: 43–56
  • Dischino D. D., Welch M. J., Kilboury M. R., Raichle M. E. Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals. Journal of Nuclear Medicine 1983; 24: 1030–1038
  • De Ferreyra E. C., Castro J. A., Diaz Gómez M. I., D'Acosta N., De Castro C. R., De Fenos O. M. Prevention and treatment of carbon tetrachloride hepatotoxicity by cystein: studies about its mechanism. Toxicology and Applied Pharmacology 1974; 27: 558–568
  • Fujita T., Iwasa J., Hansch C. A new substituent constant, π, derived from partition coefficients. Journal of American Chemical Society 1964; 86: 5175–5180
  • Funayama S., Murakami N., Izawa Y., Suzuki T., Uchida M., Tsuchiya K., Sugimoto T., Nambara T., Suzuki M., Kitagawa H. Studies on the fate of malotilate (NKK 105), a new drug for chronic hepatitis and liver cirrhosis, in rats. Journal of Pharmacobio-Dynamics 1983; 6: s-85
  • Gumucio J. J., Miller D. L. Functional implications of liver cell heterogeneity. Gastroenterology 1981; 80: 393–403
  • Gumucio J. J., Miller D. L. Liver cell heterogeneity. The Liver: Biology and Pathobiology, I. Arias, H. Popper, D. Schachter, D. A. Shafritz. Raven Press, New York 1982; 647–661
  • Iwasa J., Fujita T., Hansch C. Substituent constants for aliphatic functions obtained from partition coefficients. Journal of Medical Chemistry 1965; 8: 150–153
  • Leo A., Hansch C., Elkins D. Partition coefficients and their uses. Chemical Reviews 1971; 71: 525–616
  • Nakatsugawa T., Bradford W. L., Usui K. Hepatic disposition of parathion: uptake by isolated hepatocytes and chromatographic translobular migration. Pesticide Biochemistry and Physiology 1980; 14: 13–25
  • Nakatsugawa T., Tsuda S., Sharman W. K. Chromatographic translobular migration of xenobiotics. Pesticide Chemistry, Human Welfare and the Environment, J. Miyamoto, P. C. Kearney. Pergamon Press, Oxford 1982; Vol. 3: 469–474
  • Ohkawa H., Ohkawa R., Yamamoto I., Casida J. E. Enzymatic mechanisms and toxicological significance of hydrogen cyanide from various organothiocyanates and organonitriles in mice and houseflies. Pesticide Biochemistry and Physiology 1972; 2: 95–112
  • Rappaport A. M. Physioanatomic considerations. Diseases of the Liver, 5th edition, L. Schiff, E. Schiff. J. B. Lippincott, Philadelphia 1982; 1–57
  • Rogers K. S., Cammarata A. Superdelocalizability and charge density: a correlation with partition coefficients. Journal of Medicinal Chemistry 1969; 12: 692–693
  • Slater T. F. Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation. Nature 1966; 209: 36–40
  • Tanii H., Hashimoto K. Studies on the mechanism of acute toxicity of nitriles in mice. Archives of Toxicology 1984; 55: 47–54
  • Tanii H., Hashimoto K. Structure-acute toxicity relationship of dinitriles in mice. Archives of Toxicology 1985; 57: 88–93
  • Uchida M. Affinity and mobility of fungicidal dialkyl dithiolanylidenemalonates in rice plants. Pesticide Biochemistry and Physiology 1980; 14: 249–255
  • Uchida M., Kurihara N., Fujita T., Nakajima M. Inhibitory effects of BHC isomers on Na+-K+-ATPase, years growth and nerve conduction. Pesticide Biochemistry and Physiology 1974; 4: 260–265
  • Uchida M., Yoshida M., Kurono H., Sugimoto T. Structure-biodegradability relationship of dialkyl dithiolanylidenemalonates in rice plants and rat liver homogenate. Journal of Pesticide Science 1983; 8: 327–332
  • Willson R. A., Liem H. H., Miyai K., Muller-Eberhard U. Heterogeneous distribution of drug metabolism in elutriated rat hepatocytes. Biochemical Pharmacology 1985; 34: 1463–1470

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.