Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 11
19
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Biotransformation of terodiline. III. Opposed stereoselectivity in the benzylic and aromatic hydroxylations in rat liver microsomes

, , , , &
Pages 1269-1278 | Received 13 Sep 1986, Accepted 05 Feb 1987, Published online: 30 Sep 2009

References

  • Ariëns E. J. Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology. European Journal of Clinical Pharmacology 1984; 26: 663–668
  • Von Bahr C., Hermansson J., Lindh M. Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Journal of Pharmacology and Experimental Therapeutics 1982; 222: 458–462
  • Benthe H. F., Thieme R. A. Identification of fendiline metabolites in human urine. Biomedical Mass Spectrometry 1983; 10: 65–73
  • Brötell H., Sandqvist S. Determination of terodiline in serum and urine by gas chromatography with nitrogen detection. KabiVitrum AB, Stockholm 1983, Technical Report 83 98 056
  • Carlström D., Hackzell I. Structure and absolute Configuration of N-tert-Butyl-1-methyl-3,3-diphenylpropylamine (Terodiline) Hydrochloride, C20H28N;.C1-. Acta Crystallographica Section C 1983; 39: 1130–1132
  • Cho A. K., Lindeke B., Sum C. Y. The N-Hydroxylation of Phentermine (2-Methyl-2-Amino-1-Phenylpropane). Properties of the enzyme system. Drug Metabolism and Disposition 1974; 2: 1–8
  • Ekman G., Andersson K -E., Rud T., Ulmsten U. A double-blind, cross-over study of the effects of terodiline in women with unstable bladder. Acta Pharmacologica et Toxicologica 1980; 46(Suppl. I)39–43
  • Evans G. M., Wilkinson G. R., Shand D. G. The Disposition of Propranolol IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver. Journal of Pharmacology and Experimental Therapeutics 1973; 186: 447–454
  • Geiger P. J., Bessman S. P. Protein determination by Lowry's methods in the presence of sulfhydryl reagents. Analytical Biochemistry 1972; 49: 467–473
  • Gunne L. M. The urinary output of d- and l-amphetamine in man. Biochemical Pharmacology 1967; 16: 863–869
  • Hammar G. G., Pettersson G., Carpenter P. T. Computerized mass fragmentography and peak matching. Biomedical Mass Spectrometry 1974; 1: 397–411
  • Husted S., Andersson K -E., Sommer L., Østergaard J. R. Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder. Acta Pharmacologica et Toxicologica 1980; 46(Suppl. I)20–30
  • Miyano K., Fujii Y., Toki S. Stereoselective hydroxylation of hexobarbital enantiomers by rat liver microsomes. Drug Metabolism and Disposition 1980; 8: 104–110
  • Murphy P. J., Williams T. L., Smallwood J. K., Bellamy G., Molloy B. B. Stereoselectivity in the metabolism of drobuline (dl-1-(isopropylamino)-4,4-diphenyl-2-butanol) a new anti-arrythmic agent. Life Sciences 1978; 23: 301–312
  • Norén B., Strömberg S., Ericsson Ö., Olsson J -I., Moses P. Biotransformation of terodiline I. Identification of metabolites in dog urine by mass spectrometry. Biomedical Mass Spectrometry 1985a; 12: 367–379
  • Norén B., Strömberg S., Ericsson Ö., Vangbo B., Grälls M., Widund L., Lindeke B. Biotransformation of terodiline II. Identification of metabolites in rat urine and rat liver microsomes by mass spectrometry. Acta Pharmaceutica Suecica 1985b; 22: 131–146
  • Pohl L. R., Nelson S. D., Porter W. R., Trager W. F., Fasco M. J., Baker F. D., Fenton J. W., II. Warfarin—stereochemical aspects of its metabolism by rat liver microsomes. Biochemical Pharmacology 1976; 25: 2153–2162
  • Pohl L. R., Porter W. R., Trager W. I. Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases. Biochemical Pharmacology 1977; 26: 109–114
  • Remberg G., Eichelbaum M., Spiteller G., Dengler H. J. Metabolism of DL- 14C - prenylamine in man. Biomedical Mass Spectrometry 1977; 4: 297–304
  • Rud T., Andersson K -E., Boye N., Ulmsten U. Terodiline inhibition of human bladder contraction. Effects in vitro and in women with unstable bladder. Acta Pharmacologica et Toxicologica 1980; 46(Suppl. I)31–38
  • Topham J. C. Relation between difference spectra and metabolism. Barbiturates, drug interaction, and species difference. Biochemical Pharmacology 1970; 19: 1965–1701
  • Yacobi A., Levy G. Comparative pharmacokinetics of coumarin anticoagulants. XII. Pharmacokinetics of the warfarin enantiomers in rats. Journal of Pharmacokinetics and Biopharmaceuticals 1974; 2: 239–255

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.