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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 11
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Original Article

A comparison of in vivo and in vitro metabolites of the H1-antagonist N, N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)- 1,2-ethanediamine (methapyrilene) in the rat

S. S. Singer NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
W. Lijinsky NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
L. E. Kratz NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
N. Castagnoli Jr Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94143, USA
&
J. E. Rose Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94143, USA
Pages 1279-1291 | Received 29 Sep 1986, Published online: 30 Sep 2009

References

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  • Castagnoli N., Jr, Craig J. C., Melikian A. P., Roy S. K. Amine N-oxide rearrangements: mechanism and products of thermolysis. Tetrahedron 1970; 26: 4319–4327
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  • Habs M., Shubik P., Eisenbrand G. Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thienyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats. Journal of Cancer Research and Clinical Oncology 1986; 111: 71–74
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  • Neuman F. W., Sommer N. B., Kaslow C. E., Shriner R. L. Lepidine, Organic Synthesis Collective. J. Wiley & Sons, New York 1955; Vol. III: 519–521
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  • Ziegler R., Ho B., Castagnoli N., Jr. Trapping of metabolically generated electrophilic species with cyandie ion: metabolism of methapyrilene. Journal of Medicinal Chemistry 1981; 24: 1133–1138

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