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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 11
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Original Article

Identification of the metabolites of a new hypoglycaemic agent, midaglizole, in dogs

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Pages 1329-1339 | Received 25 Nov 1986, Published online: 30 Sep 2009

References

  • Baillie T. A., Neill E., Hughes H., Davies D. L., Davies D. S. Application of stable isotope labeling in studies of the metabolism of clonidine in rat liver. Stable Isotopes; Proceedings of the Third International Conference. Academic Press, London 1979; 415–425
  • Hakusui H., Nomura H., Suzuki W., Fujimaki M., Nakaoka M. Metabolism of midaglizole, a new hypoglycemic agent. III. Metabolism of midaglizole in rat, dog, monkey and man. Abstracts; the 106th Annual Meeting of the Pharmaceutical Society of Japan, Chiba, 1986; 604
  • Ishikawa P. Cyclic guanidines. X. Synthesis of 2-(2,2-disubstituted ethenyl- and ethyl)-2-imidazolines as potent hypoglycemics. Chemical and Pharmaceutical Bulletin 1980; 28: 1394–1402
  • Ishikawa F., Kameda K., Nakaoka M. 2-Substituted imidazoles. Japanese Patent 57–53466 [Chemical Abstracts 97–92263y(1982)], 1982a
  • Ishikawa F., Kameda K., Nakaoka M. 3-Substituted-3-phenylpropionamidines. Japanese Patent 57–53451, [Chemical Abstracts 97–92159n(1982)], 1982b
  • Kameda K., Ono S., Abiko Y. Hypoglycemic action of 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyndine dihydrochloride sesquihydrate (DG-5128), a new hypoglycemic agent. Arzneimittel Forschung 1982; 32: 39–44
  • Nomura H., Hakusui H., Kawazu T., Ishii A. Pharmacokinetics of a new hypoglycemic agent, DG-5128, in man. Japanese Journal of Clinical Pharmacology and Therapeutics 1984; 15: 43–44

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