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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 2
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Original Article

Pharmacokinetic profile of fotemustine in rat plasma by electrochemical detection

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Pages 235-242 | Received 26 Mar 1990, Accepted 12 Aug 1990, Published online: 27 Aug 2009

References

  • Alvarez A., Pauwels-Vergely C., Paraire M., Poupon M. F. Differential effects of fotemustine and BCNU on metastases and local growth in experimental models. Presented at 6 Congresso Mediterraneo di Chemioterpia. Taormina 1988
  • Bartosek I., Daniel S., Sykora S. Differential pulse polarographic determination of submicrogram quantities of carmustine and related compounds in biological fluids. Journal of Pharmaceutical Sciences 1978; 67: 1160–1163
  • Bartosek I., Russo R. G., Cattaneo M. T. Pharmacokinetics of nitrosoureas: levels of 1,3-bis-(2-chlorethyl)-1-nitrosourea (BCNU) in organs of normal and Walker 256/B carcinoma bearing rats after i.v. bolus. Tumori 1984; 70: 491–498
  • Caddy B., Idowu O. R., Stuart J. F. A high pressure liquid chromatographic procedure for monitoring 1-(2-chlorethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea levels in body fluids. Therapeutic Drug Monitoring 1982; 4: 389–395
  • Cudennec C. A., Lavielle G., Deloffre P., Bizzari J. P. Pre-clinical antitumor activity of the nitrosourea, Servier 10036. Presented at 15th International Congress of Chemotherapy. Istanbul 1987
  • Filippeschi S., Colombo T., Bassani D., De Francesco L., Arioli P., D'Incalci M., Bartosek I., Guaitani A. Antitumor activity of the novel nitrosourea S10036 in rodent tumors. Anticancer Research 1988; 8: 1351–1354
  • Foster D. O., Pardee A. B. Transport of amino acid by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips. Journal of Biological Chemistry 1969; 244: 2675–2681
  • Freed B. R., McQuinn R. L., Tilbury R. S., Digenis G. A. Distribution of 13N in rat tissues following intravenous administration of nitroso-labeled BCNU. Cancer Chemotherapy and Pharmacology 1982; 10: 16–21
  • Gibaldi M., Perrier D. Pharmacokinetics. Marcel Dekker, New York 1975
  • Gordon B. H., Richards R. P., Hiley M. P., Gray A. J., Ings R. M. J., Campbell D. B. A new method for the measurement of nitrosoureas in plasma: an h.p.l.c. procedure for the measurement of fotemustine kinetics. Xenobiotica 1989; 19: 329–339
  • Jacquillat C. I., Khayat D., Banzet P., Weil M., Fumoleaup P., Namer M., Avril M. F., Lauvin R., Kerbrat P., Vilmer C., Bizzari J. P. Multicentric study of the nitrosourea fotemustine (S10036) in advanced malignant melanoma (AMM) including patients with cerebral metastases. Presented at 2nd International Congress on Neo-Adjuvant Chemotherapy. Paris 1988
  • Khayat D., Bizzari J. P., Frenay M., Nahan H., Weil M., Goupil A., Namer M., Rouesse J., Banzet P., Jacquillat C. Interim report of phase II study of new nitrosourea S10036 in disseminated malignant melanoma. Journal of the National Cancer Institute 1988; 80: 1407–1408
  • Khayat D., Lokiec F., Bizzari J. P., Weil M., Meeus L., Sellami M., Rouesse J., Banzet P., Jacquillat C. Phase I clinical study of the new amino-acid linked nitrosourea, S10036, administered on a weekly schedule. Cancer Research 1987; 47: 6782–6785
  • Labarre P., Godeneche D., Madelmont J. C., Triana K., Mathe G., Veyre A. Qualitative and quantitative analysis of a new sulphur-containing nitrosourea in blood by high-performance liquid chromatography. Journal of Chromatography 1987; 419: 381–387
  • Levin V. A., Kabra P. A., Freeman-Dove M. A. Relationship of 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and 1-(2-chlorethyl)-3-cyclohexyl–nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors. Cancer Chetnotheraphy and Pharmacology 1978; 1: 233–242
  • Montgomery J. A., Mayo J. G. Quantitative structure-activity relationships in anticancer agents. Activity of selected nitrosoureas against a solid tumor, the Lewis lung carcinoma. Journal of Medicinal Chemistry 1974; 17: 477–480
  • Polacek J., Gunnarsson P. O., Brandin S. Determination of tauromustine, a nitrosourea-based antitumor agent, in plasma by high-performance liquid chromatography. Journal of Chromatography 1988; 425: 424–428
  • Reed D. J. Synthesis and characterisation of nitrosoureas. Anticancer and Interferon Agents. Synthesis and Properties, R. M. Offenbrite, G. B. Buther. Marcel Dekker, New York 1984; 177–202
  • Russo R. G., Bartosek I., Piazza E., Santi A. M., Libretti A., Garattini S. Differential pulse polarographic determination of BCNU pharmacokinetics in patients with lung cancer. Cancer Treatment Reports 1981; 65: 555–562
  • Russo R. G., Cattaneo M. T., Bartosek L. Pharmacokinetics of nitrosoureas: comparison of 1.3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea (CCNU) after oral and intravenous administration to rats. Tumori 1984; 70: 499–502
  • Sacchi-Landriani G., Guardabasso V., Rocchetti M. NL-FIT: a microcomputer program for non linear fitting. Computer Programs in Biomedicine 1983; 16: 35–42
  • Smith R. G., Blackstock S. C., Cheung L. K., Loo T. L. Analysis for nitrosourea antitumor agents by gas chromatography-mass spectrometry. Analytical Chemistry 1981; 53: 1205–1208
  • Smith R. G., Cheung L. K. Determination of two nitrosourea antitumor agents by chemical ionization gas chromatography-mass spectrometry. Journal of Chromatography 1982; 229: 464–469
  • Smith R. G., Cheung L. K., Feun L. G., Loo T. L. Determination of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperididyl)-1-nitrosourea in plasma by negative chemical ionization mass spectrometry. Biomedical Mass Spectrometry 1983; 10: 404–407
  • Yeager R. L., Oldfield E. H., Chatterji D. C. Quantitation of 1,3-bis(2-chloroethyl)-1-nitrosourea in plasma using high-performance liquid chromagography. Journal of Chromatography 1984; 305: 496–501

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