An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers

References

• Centers for Disease Control and Prevention. Quitting smoking among adults – United States, 2001–2010. MMWR 2011;60:1513–1519
   PubMedGoogle Scholar
• Cohen S, Lichtenstein E, Prochaska JO, Rossi JS, Gritz ER, Carr CR, Orleans CT, et al. Debunking myths about self-quitting. Evidence from 10 prospective studies of persons who attempt to quit smoking by themselves. Am Psycholog 1989;44:1355–1365
   PubMed Web of Science ®Google Scholar
• Hughes JR. Motivating and helping smokers to stop smoking. J Gen Internal Med 2003;18:1053–1057
   PubMed Web of Science ®Google Scholar
• Gonzales D, Rennard SI, Nides M, Oncken C, Azoulay S, Billing CB, Watsky EJ, et al, Varenicline Phase 3 Study G. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs. sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA 2006;296:47–55
   PubMed Web of Science ®Google Scholar
• Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE, Billing CB, et al, Varenicline Phase 3 Study G. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs. placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 2006;296:56–63
   PubMed Web of Science ®Google Scholar
• Oncken C, Gonzales D, Nides M, Rennard S, Watsky E, Billing CB, Anziano R, Reeves K. Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Internal Med 2006;166:1571–1577
   PubMed Web of Science ®Google Scholar
• Rollema H, Coe JW, Chambers LK, Hurst RS, Stahl SM, Williams KE. Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation. Trends Pharmacol Sci 2007;28:316–325
   PubMed Web of Science ®Google Scholar
• McClure EA, Vandrey RG, Johnson MW, Stitzer ML. Effects of varenicline on abstinence and smoking reward following a programmed lapse. Nicotine Tobacco Res 2013;15:139–148
   Google Scholar
• Patterson F, Jepson C, Strasser AA, Loughead J, Perkins KA, Gur RC, Frey JM, et al. Varenicline improves mood and cognition during smoking abstinence. Biolog Psychiat 2009;65:144–149
   PubMed Web of Science ®Google Scholar
• West R, Baker CL, Cappelleri JC, Bushmakin AG. Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology 2008;197:371–377
   PubMed Web of Science ®Google Scholar
• Cahill K, Stead L, Lancaster T. A preliminary benefit-risk assessment of varenicline in smoking cessation. Drug Safety 2009;32:119–135
   PubMed Web of Science ®Google Scholar
• Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev 2013;5:CD009329
   PubMed Web of Science ®Google Scholar
• Kalivas PW, Lalumiere RT, Knackstedt L, Shen H. Glutamate transmission in addiction. Neuropharmacology 2009;56:169–173
   Google Scholar
• Kalivas PW, Volkow ND. New medications for drug addiction hiding in glutamatergic neuroplasticity. Molec Psychiat 2011;16:974–986
   PubMed Web of Science ®Google Scholar
• Gipson CD, Reissner KJ, Kupchik YM, Smith AC, Stankeviciute N, Hensley-Simon ME, Kalivas PW. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci USA 2013;110:9124–9129
   PubMed Web of Science ®Google Scholar
• LaLumiere RT, Kalivas PW. Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J Neurosci 2008;28:3170–3177
   PubMed Web of Science ®Google Scholar
• Knackstedt LA, LaRowe S, Mardikian P, Malcolm R, Upadhyaya H, Hedden S, Markou A, Kalivas PW. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biolog Psychiat 2009;65:841–845
   PubMed Web of Science ®Google Scholar
• Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. N-acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci 2009;12:182–189
   PubMed Web of Science ®Google Scholar
• Ramirez-Nino AM, D’Souza MS, Markou A. N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology 2013;225:473–482
   Google Scholar
• Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE. Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. J Pharmacol Experim Therapeut 2011;337:487–493
   PubMed Web of Science ®Google Scholar
• Zhou W, Kalivas PW. N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biol Psychiat 2008;63:338–340
   PubMed Web of Science ®Google Scholar
• Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB, Kalivas PW. Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci USA 2011;108:385–390
   PubMed Web of Science ®Google Scholar
• Berk M, Malhi GS, Gray LJ, Dean OM. The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacolog Sci 2013;34:167–177
   PubMed Web of Science ®Google Scholar
• McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM. Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs 2014;28:95--106
   PubMed Web of Science ®Google Scholar
• Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiat 2012;169:805–812
   PubMed Web of Science ®Google Scholar
• Schmaal L, Berk L, Hulstijn KP, Cousijn J, Wiers RW, van den Brink W. Efficacy of N-acetylcysteine in the treatment of nicotine dependence: a double-blind placebo-controlled pilot study. Eur Addict Res 2011;17:211–216
   PubMed Web of Science ®Google Scholar
• Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Therapeut 2000;22:209–221
   PubMed Web of Science ®Google Scholar
• LaRowe SD, Kalivas PW, Nicholas JS, Randall PK, Mardikian PN, Malcolm RJ. A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict 2013;22:443–452
   PubMed Web of Science ®Google Scholar
• LaRowe SD, Mardikian P, Malcolm R, Myrick H, Kalivas P, McFarland K, Saladin M, et al. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addictions 2006;15:105–110
   PubMed Web of Science ®Google Scholar
• Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addiction 1991;86:1119–1127
   PubMedGoogle Scholar
• Sobell LC, Sobell MB, Leo GI, Cancilla A. Reliability of a timeline method: assessing normal drinkers’ reports of recent drinking and a comparative evaluation across several populations. Br J Addiction 1988;83:393–402
   PubMedGoogle Scholar
• Beck AT, Steer RA, Brown GK. Manual for Beck Depression Inventory II (BDI-II). San Antonio, TX: Psychology Corporation; 1996
   Google Scholar
• Posner K, Brent D, Lucas C, Gould M, Stanley B, Brown G, Fisher P, Zelazny J, Burke A, Oquendo M, Mann J. Columbia-Suicide Severity Rating Scale (C-SSRS), 2007
   Google Scholar
• Cox LS, Tiffany ST, Christen AG. Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tobacco Res 2001;3:7–16
   PubMedGoogle Scholar
• Hughes JR, Hatsukami D. Signs and symptoms of tobacco withdrawal. Arch Gen Psychiat 1986;43:289–294
   PubMed Web of Science ®Google Scholar
• Brauer LH, Behm FM, Lane JD, Westman EC, Perkins C, Rose JE. Individual differences in smoking reward from de-nicotinized cigarettes. Nicotine Tobacco Res 2001;3:101–109
   Google Scholar
• Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap) – a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Informatics 2009;42:377–381
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Ed.; Arlington, VA: American Psychiatric Publishing; 2013
   Google Scholar
• SRNT Subcommittee on Biochemical Verification. Biochemical verification of tobacco use and cessation. Nicotine Tobacco Res 2002;4:149–159
   PubMedGoogle Scholar