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Review Article

The emergency contraceptive drug, levonorgestrel: A review of post-coital oral and peri-coital vaginal administration for prevention of pregnancy

Pages 703-707 | Published online: 15 Nov 2011

References

  • Anon. 1998. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task force for postovulatory methods of fertility regulation. Lancet 352:428–433.
  • Baird DT. 2009. Emergency contraception: how does it work? Reproductive Biomedicine Online 18(Suppl. 1):32–36.
  • Basu A, Candelier C. 2005. Ectopic pregnancy with post-coital contraception: a case report. European Journal of Contraception and Reproductive Health Care 10:6–8.
  • Bastianelli C, Farris M, Benagiano G. 2008. Emergency contraception: A review. European Journal of Contraception and Reproductive Health Care 13:9–16.
  • Brache V, Croxatto H, Sitruk-Ware R, Maquire R, Montero JC, Kumar N . 2007. Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for ‘dual protection’ emergency contraception. Contraception 76:111–116.
  • Byamugisha JK, Mirembe FM, Faxelid E, Tumwesigye NM, Danielsson KG. 2010. A randomized clinical trial of two emergency contraceptive pill regimens in a Ugandan population. Acta Obstetricia et Gynecologica Scandinavica 89:670–676.
  • Cleland K, Raymond E, Trussell J, Cheng L, Zhu H. 2010. Ectopic pregnancy and emergency contraceptive pills: a systematic review. Obstetrics and Gynecology 115:1263–1266.
  • Compootaweep S, Leepipatpibul S. 2004. Bioequivalence study of postcoital emergency contraceptions containing levonorgestrel. Journal of Medical Association of Thailand 87 (Suppl. 2):S239–S243.
  • Croxatto HB, Brache V, Pavez M, Cochon L, Forcelledo ML, Alvarez F . 2004. Pituitary-ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75 mg dose given on the days preceding ovulation. Contraception 70:442–450.
  • Danielsson KG. 2006. Effects of levonorgestrel on ovarian function when used for emergency contraception. Minerva Ginecology 58:205–207.
  • Devoto L, Fuentes A, Palomino A, Espinoza A, Kohen P, Ranta S . 2005. Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5 mg dose by the oral and vaginal route. Fertility and Sterility 84:46–51.
  • Do Nascimento JA, Seppala M, Perdigao A, Espejo-Arce X, Munuce MJ, Hautala L . 2007. In vivo assessment of the human sperm acrosome reaction and the expression of glycodelin-A in human endometrium after levonorgestrel-emergency contraceptive pill administration. Human Reproduction 22:2190–2195.
  • Durand M, Seppala M, Cravioto Mdel C, Koistinen H, Koistinen R, Gonzalez-Macedo J. . 2005. Late follicular phase administration of levonorgestrel as an emergency contraceptive changes the secretory pattern of glycodelin in serum and endometrium during the luteal phase of the menstrual cycle. Contraception 71:451–457.
  • Espinos-Gomez JJ, Senosiain R, Mata A, Vanrell C, Bassas L, Calaf J. 2007. What is the seminal exposition among women requiring emergency contraception? A prospective, observational comparative study. European Journal of Obstetrics, Gynecology and Reproductive Biology 131:57–60.
  • Gainer E, Kenfack B, Mboudou E, Doh AS, Bouyer J. 2006. Menstrual bleeding pattern following levonorgestrel emergency contraception. Contraception 74:118–124.
  • Gainer E, Massai R, Lillo S, Reyes V, Forcelledo ML, Caviedes R . 2007. Levonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception. Human Reproduction 22:1578–1584.
  • Ghosh B, Dadhwal V, Deka D, Ramesan CK, Mittal S. 2009. Ectopic pregnancy following levonorgestrel emergency contraception: a case report. Contraception 79:155–157.
  • Glasier AF, Cameron ST, Fine PM, Logan SJ, Casale W, Van Horn J . 2010. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomized non-inferiority trial and meta analysis. Lancet 375:555–562.
  • Hansen LB, Saseen JJ, Teal SB. 2007. Levonorgestrel-only dosing strategies for emergency contraception. Pharmacotherapy 27:278–284.
  • Harper CC, Rocca CH, Darney PD, von Hertzen H, Raine TR . 2004. Tolerability of levonorgestrel emergency contraception in adolescents. American Journal of Obstetrics and Gynecology 191:1158–1163.
  • Jian Z, Linan C. 2003. Ectopic gestation following emergency contraception with levonorgestrel. European Journal of Contraception and Reproductive Health Care 8:225–228.
  • Johansson E, Brache V, Alverez F, Faundes A, Cochon L, Ranta S . 2002. Pharmacokinetic study of different dosing regimens of levonorgestrel for emergency contraception in healthy women. Human Reproduction 17:1472–1476.
  • Kives S, Hahn PM, White E, Stanczyk FZ, Reid RL. 2005. Bioavailability of the Yuzpe and levonorgestrel regimens of emergency contraception: vaginal vs. oral administration. Contraception 71:197–201.
  • Levine M, Soon JA. 2006. Risk of pregnancy among women seeking emergency contraceptives from pharmacists in British Columbia. Journal of Obstetrics and Gynecology of Canada 28:879–883.
  • Marions L, Ceken SZ, Bygdeman M, Danielsson KG. 2004. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception 69:373–377.
  • Matsushita H, Takayanagi T, Ikarashi H. 2007. Ectopic pregnancy following emergency contraception with ethinyloestradiol-levonorgestrel: a case report. European Journal of Contraception and Reproductive Health Care 12:184–186.
  • Meng CX, Marions L, Bystrom B, Gemzell-Danielsson K. 2010. Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. Human Reproduction 25:874–883.
  • Mikolajczyk RT, Stanford JB. 2007. Levonorgestrel emergency contraception: a joint analysis of effectiveness and mechanism of action. Fertility and Sterility 88:565–571.
  • Mor E, Saadat P, Kives S, White E, Reid RL, Paulson RJ . 2005. Comparison of vaginal and oral administration of emergency contraception. Fertility and Sterility 84:40–45.
  • Ngai SW, Fan S, Li S, Cheng L, Ding J, Jing X . 2005. A randomized trial to compare 24 h versus 12 h double dose regimen of levonorgestrel for emergency contraception. Human Reproduction 20:307–311.
  • Noe G, Croxatto HB, Salvatierra AM, Reyes V, Villarroel C, Munoz C . 2010. Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation. Contraception 81:414–420.
  • Novikova N, Weisberg E, Stanczyk FZ, Croxatto HB, Fraser IS. 2007. Effectiveness of levonorgestrel emergency contraception given before or after ovulation – a pilot study. Contraception 75:112–118.
  • Okewole IA, Arowojolu AO, Odusoga OL, Oloyede OA, Adeleye OA, Salu J . 2007. Effect on single administration of levonorgestrel on the menstrual cycle. Contraception 75:372–377.
  • Raymond EG, Goldberg A, Trussell J, Hays M, Roach E, Taylor D. 2006. Bleeding patterns after use of levonorgestrel emergency contraceptive pills. Contraception 73:376–381.
  • Sambol NC, Herper CC, Kim L, Liu CY, Darney P, Raine TR. 2006. Pharmacokinetics of single-dose levonorgestrel in adolescents. Contraception 74:104–109.
  • Sarkar NN. 2003. Levonorgestrel, as an emergency contraceptive drug. International Journal of Clinical Practice 57:824–828.
  • Sheffer-Mimouni G, Pauzner D, Maslovitch S, Lessing JB, Gamzu R. 2003. Ectopic pregnancies following emergency levonorgestrel contraception. Contraception 67:267–269.
  • Sitruk-Ware R, Brache V, Maguire R, Croxatto H, Kumar N, Kumar S . 2007. Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for ‘dual protection’ contraception. Contraception 75:454–460.
  • Tirelli A, Cagnacci A, Volpe A. 2008. Levonorgestrel administration in emergency contraception: bleeding pattern and pituitary-ovarian function. Contraception 77:328–332.
  • Tremblay D, Gainer E, Ulmann A. 2001. The pharmacokinetics of 750 μg levonorgestrel following administration of one single dose or two doses at 12 or 24 h interval. Contraception 64:327–331.
  • Vasilakis C, Jick SS, Jick H. 1999. The risk of venous thromboembolism in users of post coital contraceptive pills. Contraception 59:79–83.
  • Von Hertzen H, Piaggio G. 2003. Levonorgestrel and mifepristone in emergency contraception. Steroids 68:1107–1113.
  • Van Rooijen M, Silveira A, Thomassen S, Hansson LO, Rosing J, Hamsten A . 2007. Rapid activation of haemostasis after hormonal emergency contraception. Thrombosis and Haemostasis 97:15–20.

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